Reviewed, UniProtKB/Swiss-Prot Q8HYJ7 (FUT5_GORGO)

Names and origin

Protein names

Recommended name:
    Alpha-(1,3)-fucosyltransferase
    EC=2.4.1.65
Alternative name(s):
    Galactoside 3-L-fucosyltransferase
    Fucosyltransferase 5
    Fucosyltransferase V
      Short name=FucT-V
      Short name=Fuc-TV

Gene names

Name:

FUT5

Organism

Gorilla gorilla gorilla (Lowland gorilla)

Taxonomic identifier

9595 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens By similarity.
Catalytic activity	GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus › Golgi stack membrane; Single-pass type II membrane protein By similarity. Note: Membrane-bound form in trans cisternae of Golgi By similarity.
Sequence similarities	Belongs to the glycosyltransferase 10 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid glycosylation Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Alpha-(1,3)-fucosyltransferase		PRO_0000221104
Regions
	Topological domain	1 – 15	15	Cytoplasmic Potential
	Transmembrane	16 – 34	19	Signal-anchor for type II membrane protein Potential
	Topological domain	35 – 374	340	Lumenal Potential
Amino acid modifications
	Glycosylation	60	1	N-linked (GlcNAc...) Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8HYJ7-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 6507EC4629EDD75C	FASTA	374	43,122
	10 20 30 40 50 60 MDPLGPAKPQ WLWRRCLAGL LFQLLVAVCF FSYLRVSQDH ATGSPRPGLM VVEPVTRAPN 70 80 90 100 110 120 GSRCQDSAAT PAHPTLLILL WTWPFNTPVA LPRCSEMVPG AADCNITANS NVYPQADAVI 130 140 150 160 170 180 VHHWDIMYNP SANLLPPTRP QGQRWIWFSM ESPSNCRHLE ALDGYFNLTM SYRSDSDIFT 190 200 210 220 230 240 PYGWLEPWSG QPAHPPLNLS AKTELVAWAV SNWKPDSARV RYYQSLKAHL KVDVYGHSHK 250 260 270 280 290 300 PLPKGTMMET LSRYKFYLAF ENSLHLDYIT EKLWRNALEA WAVPVVLGPS RGNYERFLPP 310 320 330 340 350 360 DAFIHVDDFQ SPKDLARYLQ ELDKDHARYL SYFRWRETLR PRSFSWALDF CKACWKLQQE 370 SRYQTVRSIA AWFT

References

[1]

"Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain." Dupuy F., Germot A., Julien R., Maftah A. Glycobiology 14:347-356(2004) [PubMed: 14718375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF515436 Genomic DNA. Translation: AAO15992.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT10. Glycosyltransferase Family 10.
Phylogenomic databases
HOVERGEN	Q8HYJ7.
Family and domain databases
InterPro	IPR001503. Glyco_trans_10. [Graphical view]
PANTHER	PTHR11929. Glyco_trans_10. 1 hit.
Pfam	PF00852. Glyco_transf_10. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FUT5_GORGO

Accession

Primary (citable) accession number: Q8HYJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	March 1, 2003
Last modified:	October 13, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)