Reviewed, UniProtKB/Swiss-Prot Q8HYE4 (AL1A1_MACFA)

Names and origin

Protein names

Recommended name:
    Retinal dehydrogenase 1
      Short name=RALDH 1
      Short name=RalDH1
    EC=1.2.1.36
Alternative name(s):
    Aldehyde dehydrogenase family 1 member A1
    Aldehyde dehydrogenase, cytosolic
    ALHDII
    ALDH-E1

Gene names

Name:

ALDH1A1

Organism

Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	501 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid By similarity.
Catalytic activity	Retinal + NAD+ + H2O = retinoate + NADH.
Pathway	Cofactor metabolism; retinol metabolism.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Acetylation
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	retinal dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 501	500	Retinal dehydrogenase 1		PRO_0000056416
Regions
	Nucleotide binding	246 – 251	6	NAD By similarity
Sites
	Active site	269	1	Proton acceptor By similarity
	Active site	303	1	Nucleophile By similarity
	Site	170	1	Transition state stabilizer By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8HYE4-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: E3864A9190BBD6B2	FASTA	501	54,736
	10 20 30 40 50 60 MSSSGTSDLP VLPTDLKIQY TKIFINNEWH DSVSGKKFPV FNPATEEELC QVEEGDKADV 70 80 90 100 110 120 DKAVKAARQA FQIGSPWRTM DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL 130 140 150 160 170 180 NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI GVCGQIIPWN FPLVMLIWKI 190 200 210 220 230 240 GPALSCGNTV VVKPAEQTPL TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID 250 260 270 280 290 300 KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA DADLDNAVEF AHHGVFYHQG 310 320 330 340 350 360 QCCIAASRIF VEESIYDEFV RRSVERAKKY ILGNPLTPGA TQGPQIDKEQ YDKILDLIES 370 380 390 400 410 420 GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE IFGPVQQIMK FKSLDDVIKR 430 440 450 460 470 480 ANNTFYGLSA GVFTNDIDKA VTISSALQAG TVWVNCYGVV TAQCPFGGFK MSGNGRELGE 490 500 YGFHEYTEVK TVTVKISQKN S

References

[1]	"Cloning of monkey RALDH1 and characterization of retinoid metabolism in monkey kidney proximal tubule cells." Brodeur H., Gagnon I., Mader S., Bhat P.V. J. Lipid Res. 44:303-313(2003) [PubMed: 12576512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney proximal tubule.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF542418 mRNA. Translation: AAN85861.1.
3D structure databases
HSSP	HSSP built from PDB template 1BXS based on UniProtKB P51977.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q8HYE4.
Enzyme and pathway databases
BRENDA	1.2.1.36. 3438.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL1A1_MACFA

Accession

Primary (citable) accession number: Q8HYE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 40 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)