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Protein
Submitted name:

Potassium channel subfamily K member 2

Gene

Kcnk2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-1299503. TWIK related potassium channel (TREK).

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium channel subfamily K member 2Imported
Submitted name:
Potassium two pore domain channel subfamily K member 2Imported
Gene namesi
Name:Kcnk2Imported
Synonyms:KCNK2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 68HelicalSequence analysisAdd BLAST19
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Transmembranei208 – 229HelicalSequence analysisAdd BLAST22
Transmembranei241 – 259HelicalSequence analysisAdd BLAST19
Transmembranei274 – 296HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075183.

Expressioni

Gene expression databases

BgeeiENSBTAG00000004407.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005781.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 180Ion_trans_2InterPro annotationAdd BLAST64
Domaini219 – 297Ion_trans_2InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000013106.
HOVERGENiHBG052234.
KOiK04913.
OMAiAINVMKW.
OrthoDBiEOG091G0E3R.
TreeFamiTF313947.

Family and domain databases

InterProiView protein in InterPro
IPR003280. 2pore_dom_K_chnl.
IPR003976. 2pore_dom_K_chnl_TREK.
IPR013099. K_chnl_dom.
PfamiView protein in Pfam
PF07885. Ion_trans_2. 2 hits.
PRINTSiPR01333. 2POREKCHANEL.
PR01499. TREKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q8HY88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPDLLDPK SAAQNSKPRL SFSTKPTVLA SRVESDTTIN VMKWKTVSTI
60 70 80 90 100
FLVVVLYLII GATVFKALEQ PHEISQRTTI VIQKQTFISQ HACVNSTELD
110 120 130 140 150
ELIQQIVAAI NAGIIPLGNT SNQISHWDLG SSFFFAGTVI TTIGFGNISP
160 170 180 190 200
RTEGGKIFCI IYALLGIPLF GFLLAGVGDQ LGTIFGKGIA KVEDTFIKWN
210 220 230 240 250
VSQTKIRIIS TIIFILFGCV LFVALPAIIF KHIEGWSALD AIYFVVITLT
260 270 280 290 300
TIGFGDYVAG GSDIEYLDFY KPVVWFWILV GLAYFAAVLS MIGDWLRVIS
310 320 330 340 350
KKTKEEVGEF RAHAAEWTAN VTAEFKETRR RLSVEIYDKF QRATSIKRKL
360 370 380 390 400
SAELAGNHNQ ELTPCRRTLS VNHLASERDV LPSLLKTESI YLNGLTPHCA
410
GEEIAVIENI K
Length:411
Mass (Da):45,439
Last modified:March 1, 2003 - v1
Checksum:iA185EAC20A68CCDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02043651 Genomic DNA. No translation available.
DAAA02043652 Genomic DNA. No translation available.
DAAA02043653 Genomic DNA. No translation available.
DAAA02043654 Genomic DNA. No translation available.
DAAA02043655 Genomic DNA. No translation available.
DAAA02043656 Genomic DNA. No translation available.
DAAA02043657 Genomic DNA. No translation available.
DAAA02043658 Genomic DNA. No translation available.
DAAA02043659 Genomic DNA. No translation available.
DAAA02043660 Genomic DNA. No translation available.
AY148474 mRNA. Translation: AAN37591.1.
RefSeqiNP_777111.1. NM_174686.2.
XP_005217386.1. XM_005217329.3.
UniGeneiBt.12536.

Genome annotation databases

EnsembliENSBTAT00000005781; ENSBTAP00000005781; ENSBTAG00000004407.
GeneIDi282590.
KEGGibta:282590.

Similar proteinsi

Entry informationi

Entry nameiQ8HY88_BOVIN
AccessioniPrimary (citable) accession number: Q8HY88
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported