Q8HY82 (CATS_SAIBB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin S
EC=3.4.22.27

Gene names

Name:

CTSS

Organism

Saimiri boliviensis boliviensis (Bolivian squirrel monkey)

Taxonomic identifier

39432 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Saimiriinae › Saimiri

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N By similarity.
Catalytic activity	Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Propeptide	18 – 114	97	Activation peptide By similarity		PRO_0000026319
	Chain	115 – 330	216	Cathepsin S		PRO_0000026320
Sites
	Active site	139	1	By similarity
	Active site	277	1	By similarity
	Active site	297	1	By similarity
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Disulfide bond	126 ↔ 223		By similarity
	Disulfide bond	136 ↔ 179		By similarity
	Disulfide bond	170 ↔ 212		By similarity
	Disulfide bond	271 ↔ 319		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8HY82 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 4ECE3129F2418C34	FASTA	330	37,346
	10 20 30 40 50 60 MKQLVCVLFV CSSAVTQLHK DPTLDHHWNL WKKTYGKQYK EKNEEAVRRL IWEKNLKFVM 70 80 90 100 110 120 LHNLEHSMGM HSYDLGMNHL GDMTSEEVMS LMSSLRVPNQ WQRNITYKSN PNQMLPDSVD 130 140 150 160 170 180 WREKGCVTEV KYQGSCGACW AFSAVGALEA QLKLKTGKLV SLSAQNLVDC SEKYGNKGCN 190 200 210 220 230 240 GGFMTEAFQY IIDNKGIDSE ASYPYKATDQ KCQYDSKYRA ATCSKYTELP YGREDVLKEA 250 260 270 280 290 300 VANKGPVCVG VDASHPSFFL YRSGVYYDPA CTQKVNHGVL VIGYGDLNGK EYWLVKNSWG 310 320 330 SNFGEQGYIR MARNKGNHCG IASYPSYPEI

References

[1]	"Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S." Baker S.M., Karlsson L., Thurmond R.L. Protein Expr. Purif. 28:93-101(2003) [PubMed: 12651112] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY156691 mRNA. Translation: AAO13008.1.
3D structure databases
ProteinModelPortal	Q8HY82.
SMR	Q8HY82. Positions 18-330.
ModBase	Search...
Protein family/group databases
MEROPS	C01.034.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG011513.
Family and domain databases
InterPro	IPR000169. Pept_cys_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. Peptidase_C1A. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATS_SAIBB

Accession

Primary (citable) accession number: Q8HY82

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program