Q8HY81 (CATS_CANFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cathepsin S
EC=3.4.22.27

Gene names

Name:

CTSS

Organism

Canis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]

Taxonomic identifier

9615 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › Canis lupus

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N By similarity.
Catalytic activity	Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
Subcellular location	Lysosome By similarity.
Sequence similarities	Belongs to the peptidase C1 family.

Ontologies

Keywords
Cellular component	Lysosome
Domain	Signal
Molecular function	Hydrolase Protease Thiol protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	lysosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Propeptide	17 – 114	98	Activation peptide By similarity		PRO_0000026311
	Chain	115 – 331	217	Cathepsin S		PRO_0000026312
Sites
	Active site	139	1	By similarity
	Active site	278	1	By similarity
	Active site	298	1	By similarity
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Disulfide bond	126 ↔ 224		By similarity
	Disulfide bond	136 ↔ 180		By similarity
	Disulfide bond	170 ↔ 213		By similarity
	Disulfide bond	272 ↔ 320		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8HY81 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 8E873B7A02105C6A	FASTA	331	37,228
	10 20 30 40 50 60 MKWLVGLLPL CSYAVAQVHK DPTLDHHWNL WKKTYSKQYK EENEEVARRL IWEKNLKFVM 70 80 90 100 110 120 LHNLEHSMGM HSYDLGMNHL GDMTGEEVIS LMGSLRVPSQ WQRNVTYRSN SNQKLPDSVD 130 140 150 160 170 180 WREKGCVTEV KYQGSCGACW AFSAVGALEA QLKLKTGKLV SLSAQNLVDC STEKYGNKGC 190 200 210 220 230 240 NGGFMTTAFQ YIIDNNGIDS EASYPYKAMN GKCRYDSKKR AATCSKYTEL PFGSEDALKE 250 260 270 280 290 300 AVANKGPVSV AIDASHYSFF LYRSGVYYEP SCTQNVNHGV LVVGYGNLNG KDYWLVKNSW 310 320 330 GLNFGDQGYI RMARNSGNHC GIASYPSYPE I

References

[1]	"Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S." Baker S.M., Karlsson L., Thurmond R.L. Protein Expr. Purif. 28:93-101(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY156692 mRNA. Translation: AAO13009.1.
RefSeq	NP_001002938.2. NM_001002938.2.
UniGene	Cfa.1661.
3D structure databases
ProteinModelPortal	Q8HY81.
SMR	Q8HY81. Positions 18-331.
ModBase	Search...
Protein-protein interaction databases
STRING	9615.ENSCAFP00000017782.
Protein family/group databases
MEROPS	C01.034.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	403400.
KEGG	cfa:403400.
Organism-specific databases
CTD	1520.
Phylogenomic databases
eggNOG	COG4870.
HOGENOM	HOG000230774.
HOVERGEN	HBG011513.
InParanoid	Q8HY81.
KO	K01368.
OrthoDB	EOG4JM7Q2.
Family and domain databases
InterPro	IPR025661. Pept_asp_AS. IPR000169. Pept_cys_AS. IPR025660. Pept_his_AS. IPR013128. Peptidase_C1A. IPR000668. Peptidase_C1A_C. IPR013201. Prot_inhib_I29. [Graphical view]
PANTHER	PTHR12411. PTHR12411. 1 hit.
Pfam	PF08246. Inhibitor_I29. 1 hit. PF00112. Peptidase_C1. 1 hit. [Graphical view]
PRINTS	PR00705. PAPAIN.
SMART	SM00848. Inhibitor_I29. 1 hit. SM00645. Pept_C1. 1 hit. [Graphical view]
PROSITE	PS00640. THIOL_PROTEASE_ASN. 1 hit. PS00139. THIOL_PROTEASE_CYS. 1 hit. PS00639. THIOL_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816922.

Entry information

Entry name

CATS_CANFA

Accession

Primary (citable) accession number: Q8HY81

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	March 1, 2003
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program