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Protein

Thyrotropin receptor

Gene

TSHR

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin receptorUniRule annotation
Gene namesi
Name:TSHRUniRule annotationImported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei419 – 440HelicalUniRule annotationAdd BLAST22
Transmembranei452 – 477HelicalUniRule annotationAdd BLAST26
Transmembranei497 – 517HelicalUniRule annotationAdd BLAST21
Transmembranei538 – 560HelicalUniRule annotationAdd BLAST23
Transmembranei580 – 606HelicalUniRule annotationAdd BLAST27
Transmembranei627 – 649HelicalUniRule annotationAdd BLAST23
Transmembranei661 – 681HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21UniRule annotationAdd BLAST21
ChainiPRO_500514447222 – 764Thyrotropin receptorUniRule annotationAdd BLAST743

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000025913.

Structurei

3D structure databases

ProteinModelPortaliQ8HY53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini431 – 678G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST248

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.UniRule annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
KOiK04249.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002274. TSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF0. PTHR24372:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01145. TSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8HY53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPADLLQLV LLLVLPRDLG GKGCSSPPCE CQQEEDFRVT CKDIQRIPSL
60 70 80 90 100
PPSTQTLKLI ETRLRTIPSH AFSSLPNISR IYLSIDATLQ QLETHSFYNL
110 120 130 140 150
NKVTHIEIRN TRSLTYIDPD ALKELPLLKF LGIFNTGLKM FPDLTKVYST
160 170 180 190 200
DIFFILEITD NPYMTSIPVN AFQGLCNETL TLKLYNNGFT SIQGYAFNGT
210 220 230 240 250
KLDAVYLNKN KYLTVIDKDA FGGVYSGPSL LDVSHTSVTA LPSKGLEHLK
260 270 280 290 300
ELIARNTWTL KKLPLSLSFL HLTRADLSYP SHCCAFKNQK KIRGIPESLM
310 320 330 340 350
CNESSMQSLR QRKSVNALNS PLHQEYEENL DDGIVGYKEK SKFQDAHNNA
360 370 380 390 400
HYYVFFEEQE DEIIGFGQEL KNPQEETLQA FDSHYDYTVC GDNEDMVCTP
410 420 430 440 450
KSDEFNPCED IMGYKFLRIV VWFVSLLALL GNVFVLLILL TSHYKLNVPR
460 470 480 490 500
FLMCNLAFAD FCMGMYLLLI ASVDLYTHSE YYNHAIDWQT GPGCNTAGFF
510 520 530 540 550
TVFASELSVY TLTVITLERW YAITFAMRLD RKIRLRHACA IMVGGWVCCF
560 570 580 590 600
LLALLPLVGI SSYAKVSICL PMDTETPLAL AYIVFVLTLN IVAFVIVCCC
610 620 630 640 650
YVKIYITVRN PQYNPGDKDT KIAKRMAVLI FTDFICMAPI SFYALSAILN
660 670 680 690 700
KPLITVSNSK ILLVLFYPLN SCANPFLYAI FTKAFQRDVF ILLSKFGICK
710 720 730 740 750
RQAQAYRGQR VPPKNSTDIQ VQKVTHEMRQ DLHNMQDVYE LLENSHLTPK
760
KQGQISEEYT QTVL
Length:764
Mass (Da):86,853
Last modified:March 1, 2003 - v1
Checksum:iEFADC782F6F4F7F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei764Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169400 mRNA. Translation: AAO11783.1.
RefSeqiNP_001182324.1. NM_001195395.1.
UniGeneiMmu.3677.

Genome annotation databases

GeneIDi574251.
KEGGimcc:574251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY169400 mRNA. Translation: AAO11783.1.
RefSeqiNP_001182324.1. NM_001195395.1.
UniGeneiMmu.3677.

3D structure databases

ProteinModelPortaliQ8HY53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000025913.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi574251.
KEGGimcc:574251.

Organism-specific databases

CTDi7253.

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
KOiK04249.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002274. TSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF0. PTHR24372:SF0. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01145. TSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8HY53_MACMU
AccessioniPrimary (citable) accession number: Q8HY53
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 5, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.