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Q8HY46 (CPT1B_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified October 3, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carnitine O-palmitoyltransferase 1, muscle isoform
Short name=CPT1-M
EC=2.3.1.21
Alternative name(s):
Carnitine O-palmitoyltransferase I, muscle isoform
Short name=CPT I
Short name=CPTI-M
Carnitine palmitoyltransferase 1B
Gene names
Name:CPT1B
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length772 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

Pathway

Lipid metabolism; fatty acid beta-oxidation.

Subcellular location

Mitochondrion outer membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the carnitine/choline acetyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 772772Carnitine O-palmitoyltransferase 1, muscle isoform
PRO_0000210164

Regions

Topological domain1 – 4747Cytoplasmic Potential
Transmembrane48 – 7326Helical; Potential
Topological domain74 – 10229Mitochondrial intermembrane Potential
Transmembrane103 – 12220Helical; Potential
Topological domain123 – 772650Cytoplasmic Potential
Region555 – 56713Coenzyme A binding By similarity

Sites

Active site4731Proton acceptor By similarity
Binding site5891Carnitine By similarity
Binding site6021Carnitine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8HY46 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EE3F20B9A406CDE1

FASTA77288,230
        10         20         30         40         50         60 
MAEAHQAVAF QFTVTPEGVD FRLSREALKH IYLSGINSWK KRLIRIKNGI LRGVYPGSPT 

        70         80         90        100        110        120 
SWLVVASATA GSSYYNVDIS MGLVNHIQRC LPERYGPYWT PQTRALLSMA VVSTGVWMIG 

       130        140        150        160        170        180 
IFFFRQTLKL LLSYHGWMFE MHGQSSRVTK VWAICVRLLS SRRPMLYSFQ TSLPKLPVPS 

       190        200        210        220        230        240 
VPATIHRYLE SVQHLLDDEE YSRKEMLAKE FQEKTAPRLQ KYLVLKSWWA TNYVSDWWEE 

       250        260        270        280        290        300 
YVYLRGRTPL MVNSNYYVMD LVLMRSTDVQ AARLGNAVHA MIMYRRKLDR EDIKPVMALG 

       310        320        330        340        350        360 
IVPMCSYQME RMFNTTRIPG KDTDTLQHLT DSRHVAVYHK GRFFKVWLYE GSRLLKPCEL 

       370        380        390        400        410        420 
ELQFQRILDD PSPPQPGEEK LAALTAGGRV EWAQARQAFF SSGKNKFALD AIERAAFFVA 

       430        440        450        460        470        480 
LDEESHHYDP EDEASLSLYG KALLHGNCYN RWFDKSFTLI AFKNGQLGLN TEHAWADAPI 

       490        500        510        520        530        540 
IGHLWEFVLG TDTFHLGYTE TGHCLGKPNP MLAPPQRLQW DIPEQCQAVI ESSYQVAKAL 

       550        560        570        580        590        600 
ADDVELYCFQ FLPFGKGLIK KCRTSPDAFV QIALQLAYFR DRGKFCLTYE ASMTRMFREG 

       610        620        630        640        650        660 
RTETVRSCTR ESTAFVQAMV EGRRVKADLQ DLFRKAAQKH QNMYRLAMTG AGIDRHLFCL 

       670        680        690        700        710        720 
YVVSKYLGVS SPFLAEVLSE PWRLSTSQIA QFQIRMFDPN KYPNHLGAGG GFGPVADDGY 

       730        740        750        760        770 
GVSYMIAGEN TIFFHVSSKF SSSETNAQRF GNHIRQALLD LADLFQVPKT DS

« Hide

References

[1]"Pig carnitine palmitoyltransferase IB muscle isoform."
Debata C., Penn D.
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY181062 mRNA. Translation: AAO12153.1.
UniGeneSsc.15966.

3D structure databases

ProteinModelPortalQ8HY46.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG003458.

Enzyme and pathway databases

UniPathwayUPA00659.

Family and domain databases

InterProIPR000542. Carn_acyl_trans.
[Graphical view]
PANTHERPTHR22589. PTHR22589. 1 hit.
PfamPF00755. Carn_acyltransf. 1 hit.
[Graphical view]
PROSITEPS00439. ACYLTRANSF_C_1. 1 hit.
PS00440. ACYLTRANSF_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCPT1B_PIG
AccessionPrimary (citable) accession number: Q8HY46
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2003
Last modified: October 3, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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