Reviewed, UniProtKB/Swiss-Prot Q8HY33 (CAH1_MONDO)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 1
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase I
      Short name=CA-I
    Carbonate dehydratase I

Gene names

Name:

CA1

Organism

Monodelphis domestica (Short-tailed gray opossum)

Taxonomic identifier

13616 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Metatheria › Didelphimorphia › Didelphidae › Monodelphis

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Carbonic anhydrase 1		PRO_0000077412
Sites
	Metal binding	95	1	Zinc; catalytic
	Metal binding	97	1	Zinc; catalytic
	Metal binding	120	1	Zinc; catalytic

Sequences

	Sequence		Length	Mass (Da)
	Q8HY33-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 38A217356BCD5C9A	FASTA	262	29,175
	10 20 30 40 50 60 MANLNWSYEG ENGPEHWSKL YPIANGDNQS PIDIKTKEVK HDASLKPISV SYNPATAKEI 70 80 90 100 110 120 VNVSHNFQVN FEDKDNQSVL KGGPFTGSFR LRQFHFHWGT ADDHGSEHTV DGVKYSSELH 130 140 150 160 170 180 IVHWNSEKYS SFSEAAEKPD GLAIIAVFIK AGQANPGLQK VIDALSSIKT KGKKAPFANF 190 200 210 220 230 240 DPSLLIPQSS DYWSYHGSLT HPPLHESVTW IIYREPISAS SEQLAKFRSL LSTAEGEKAS 250 260 SILHNHRLPQ PLKGRQVKAS FK

References

[1]	"Characterisation of opossum (Monodelphis domestica) carbonic anhydrase I and alpha globin coding sequences." Barome P.O. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ417908 mRNA. Translation: CAD10681.1.
RefSeq	NP_001028142.1.
UniGene	Mdm.243
3D structure databases
HSSP	HSSP built from PDB template 1HUG based on UniProtKB P00915.
SMR	Q8HY33. Positions 5-261.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMODT00000007364; ENSMODP00000007216; ENSMODG00000005833; Monodelphis domestica. [Genome view]
GeneID	497246.
KEGG	mdo:497246.
Organism-specific databases
CTD	497246.
Phylogenomic databases
HOVERGEN	Q8HY33.
OMA	TKGKRAP.
Enzyme and pathway databases
BRENDA	4.2.1.1. 277713.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018443. Carbonic_anhydrase_CA13. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF31. Carbonic_anhydrase_CA13. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAH1_MONDO

Accession

Primary (citable) accession number: Q8HY33

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)