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Protein

Relaxin-3

Gene

RLN3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).By similarity

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-418555. G alpha (s) signalling events.
R-SSC-418594. G alpha (i) signalling events.
R-SSC-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name:
Insulin-like peptide 7
Cleaved into the following 2 chains:
Gene namesi
Name:RLN3
Synonyms:INSL7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Peptidei27 – 5327Relaxin-3 B chainPRO_0000016091Add
BLAST
Propeptidei56 – 11661Connecting peptide1 PublicationPRO_0000016092Add
BLAST
Peptidei117 – 14024Relaxin-3 A chainPRO_0000016093Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 127Interchain (between B and A chains)By similarity
Disulfide bondi48 ↔ 140Interchain (between B and A chains)By similarity
Disulfide bondi126 ↔ 131By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ8HY17.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014634.

Structurei

3D structure databases

ProteinModelPortaliQ8HY17.
SMRiQ8HY17. Positions 27-53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZRS. Eukaryota.
ENOG41121Z2. LUCA.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8HY17.
KOiK05255.
OMAiCKRGCSK.
OrthoDBiEOG7H1JNG.
TreeFamiTF333404.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HY17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPLLLLL LAVWVLAGEL WLRTEARASP YGVKLCGREF IRAVIFTCGG
60 70 80 90 100
SRWRRSDMLA HEALGDVFSD TDSNADSELD EAMASSEWLA LTKSPETFYG
110 120 130 140
VQPGWQRTPG ALRGSRDVLA GLSSNCCKWG CSKSEISSLC
Length:140
Mass (Da):15,360
Last modified:March 1, 2003 - v1
Checksum:i063775801F6803B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076661 Genomic DNA. Translation: BAC53769.1.
DQ974115 Genomic DNA. Translation: ABJ98405.1.
RefSeqiNP_001039144.1. NM_001045679.1.
XP_013850120.1. XM_013994666.1.
XP_013850121.1. XM_013994667.1.
UniGeneiSsc.30457.
Ssc.95413.

Genome annotation databases

EnsembliENSSSCT00000015039; ENSSSCP00000014634; ENSSSCG00000013765.
GeneIDi503836.
KEGGissc:503836.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076661 Genomic DNA. Translation: BAC53769.1.
DQ974115 Genomic DNA. Translation: ABJ98405.1.
RefSeqiNP_001039144.1. NM_001045679.1.
XP_013850120.1. XM_013994666.1.
XP_013850121.1. XM_013994667.1.
UniGeneiSsc.30457.
Ssc.95413.

3D structure databases

ProteinModelPortaliQ8HY17.
SMRiQ8HY17. Positions 27-53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014634.

Proteomic databases

PaxDbiQ8HY17.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000015039; ENSSSCP00000014634; ENSSSCG00000013765.
GeneIDi503836.
KEGGissc:503836.

Organism-specific databases

CTDi117579.

Phylogenomic databases

eggNOGiENOG410IZRS. Eukaryota.
ENOG41121Z2. LUCA.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8HY17.
KOiK05255.
OMAiCKRGCSK.
OrthoDBiEOG7H1JNG.
TreeFamiTF333404.

Enzyme and pathway databases

ReactomeiR-SSC-418555. G alpha (s) signalling events.
R-SSC-418594. G alpha (i) signalling events.
R-SSC-444821. Relaxin receptors.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Comparing the expression of two different relaxin genes in pig and the association of RLN1 and RLN3 to teat development in pigs."
    Chomdej S., Yammuen-Art S., Jonas E., Jennen D., Ponsuksili S., Schellander K., Wimmers K.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2."
    Sudo S., Kumagai J., Nishi S., Layfield S., Ferraro T., Bathgate R.A.D., Hsueh A.J.W.
    J. Biol. Chem. 278:7855-7862(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LGR7.
  4. "Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein coupled receptor GPCR135."
    Liu C., Eriste E., Sutton S., Chen J., Roland B., Kuei C., Farmer N., Joernvall H., Sillard R., Lovenberg T.W.
    J. Biol. Chem. 278:50754-50764(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-53 AND 117-140, INTERACTION WITH RELAXIN-3 RECEPTOR-1.

Entry informationi

Entry nameiREL3_PIG
AccessioniPrimary (citable) accession number: Q8HY17
Secondary accession number(s): A7YKU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: January 20, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.