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Protein

Relaxin-3

Gene

RLN3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-SSC-418555. G alpha (s) signalling events.
R-SSC-418594. G alpha (i) signalling events.
R-SSC-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3
Alternative name(s):
Insulin-like peptide INSL7
Short name:
Insulin-like peptide 7
Cleaved into the following 2 chains:
Gene namesi
Name:RLN3
Synonyms:INSL7
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
PeptideiPRO_000001609127 – 53Relaxin-3 B chainAdd BLAST27
PropeptideiPRO_000001609256 – 116Connecting peptide1 PublicationAdd BLAST61
PeptideiPRO_0000016093117 – 140Relaxin-3 A chainAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 127Interchain (between B and A chains)By similarity
Disulfide bondi48 ↔ 140Interchain (between B and A chains)By similarity
Disulfide bondi126 ↔ 131By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ8HY17.
PRIDEiQ8HY17.

Expressioni

Gene expression databases

BgeeiENSSSCG00000013765.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000014634.

Structurei

3D structure databases

ProteinModelPortaliQ8HY17.
SMRiQ8HY17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZRS. Eukaryota.
ENOG41121Z2. LUCA.
GeneTreeiENSGT00510000048203.
HOGENOMiHOG000111888.
HOVERGENiHBG045048.
InParanoidiQ8HY17.
KOiK05255.
OMAiEARASPY.
OrthoDBiEOG091G0Y3D.
TreeFamiTF333404.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PRINTSiPR00276. INSULINFAMLY.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HY17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPLLLLL LAVWVLAGEL WLRTEARASP YGVKLCGREF IRAVIFTCGG
60 70 80 90 100
SRWRRSDMLA HEALGDVFSD TDSNADSELD EAMASSEWLA LTKSPETFYG
110 120 130 140
VQPGWQRTPG ALRGSRDVLA GLSSNCCKWG CSKSEISSLC
Length:140
Mass (Da):15,360
Last modified:March 1, 2003 - v1
Checksum:i063775801F6803B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076661 Genomic DNA. Translation: BAC53769.1.
DQ974115 Genomic DNA. Translation: ABJ98405.1.
RefSeqiNP_001039144.1. NM_001045679.1.
XP_013850120.1. XM_013994666.1.
XP_013850121.1. XM_013994667.1.
UniGeneiSsc.30457.
Ssc.95413.

Genome annotation databases

EnsembliENSSSCT00000015039; ENSSSCP00000014634; ENSSSCG00000013765.
GeneIDi503836.
KEGGissc:503836.

Similar proteinsi

Entry informationi

Entry nameiREL3_PIG
AccessioniPrimary (citable) accession number: Q8HY17
Secondary accession number(s): A7YKU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: August 30, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families