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Protein

Craniofacial development protein 1

Gene

CFDP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role during embryogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Craniofacial development protein 1
Alternative name(s):
Bucentaur
h-type BCNT protein
Gene namesi
Name:CFDP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Craniofacial development protein 1PRO_0000212491Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineBy similarity
Modified residuei84 – 841PhosphoserineBy similarity
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei115 – 1151PhosphoserineBy similarity
Modified residuei248 – 2481PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8HXY9.
PRIDEiQ8HXY9.

Expressioni

Tissue specificityi

Brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020504.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini216 – 29782BCNT-CPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni176 – 21540HydrophilicAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 111110Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 BCNT-C domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4776. Eukaryota.
ENOG4111H9K. LUCA.
GeneTreeiENSGT00390000018141.
HOGENOMiHOG000247045.
HOVERGENiHBG081120.
InParanoidiQ8HXY9.
OMAiAGFENSG.
OrthoDBiEOG7FZ01C.
TreeFamiTF313182.

Family and domain databases

InterProiIPR011421. BCNT-C.
IPR027124. Swc5/CFDP.
[Graphical view]
PANTHERiPTHR23227. PTHR23227. 1 hit.
PfamiPF07572. BCNT. 1 hit.
[Graphical view]
PROSITEiPS51279. BCNT_C. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8HXY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEFDSEDFS TSEEDEDYVP SGGEYSEDDI NELVKEDEVD GEEETQKTKG
60 70 80 90 100
TKRKAESVLA RKRKQGGLSL EEDEEDANEE SGGSSSEEED AATEQQKGVE
110 120 130 140 150
SEDARKKKED ELWASFLNDV GPKSKVPPST HVKTGEETEE TSSSHLVKAE
160 170 180 190 200
RLEKPKETEK VKITKVFDFA GEEVRVIKEV DATSKEAKSF FKQNEKEKPQ
210 220 230 240 250
SNVPPAVPSL PAGSGLKRSS GMSSLLGKIG AKKQKMSTLE KSKLDWESFK
260 270 280 290
EEEGIGEELA IHNRGKEGYI ERKAFLDRVD HRQFEIERDL RLSKMKP
Length:297
Mass (Da):33,355
Last modified:March 1, 2003 - v1
Checksum:iD4A944BC8740373C
GO
Isoform 2 (identifier: Q8HXY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-297: Missing.

Show »
Length:215
Mass (Da):23,823
Checksum:i7287C8B98E9D05C8
GO

Sequence cautioni

The sequence BAC11952.1 differs from that shown. Reason: Frameshift at position 171. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei216 – 29782Missing in isoform 2. 2 PublicationsVSP_016241Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081003 Genomic DNA. Translation: BAC11952.1. Frameshift.
AB081004 mRNA. Translation: BAC11953.1.
AB081095 Genomic DNA. Translation: BAC15593.1.
BC112462 mRNA. Translation: AAI12463.1.
RefSeqiNP_776693.1. NM_174268.1. [Q8HXY9-1]
UniGeneiBt.64709.

Genome annotation databases

EnsembliENSBTAT00000020504; ENSBTAP00000020504; ENSBTAG00000015427. [Q8HXY9-1]
GeneIDi281682.
KEGGibta:281682.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB081003 Genomic DNA. Translation: BAC11952.1. Frameshift.
AB081004 mRNA. Translation: BAC11953.1.
AB081095 Genomic DNA. Translation: BAC15593.1.
BC112462 mRNA. Translation: AAI12463.1.
RefSeqiNP_776693.1. NM_174268.1. [Q8HXY9-1]
UniGeneiBt.64709.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020504.

Proteomic databases

PaxDbiQ8HXY9.
PRIDEiQ8HXY9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020504; ENSBTAP00000020504; ENSBTAG00000015427. [Q8HXY9-1]
GeneIDi281682.
KEGGibta:281682.

Organism-specific databases

CTDi10428.

Phylogenomic databases

eggNOGiKOG4776. Eukaryota.
ENOG4111H9K. LUCA.
GeneTreeiENSGT00390000018141.
HOGENOMiHOG000247045.
HOVERGENiHBG081120.
InParanoidiQ8HXY9.
OMAiAGFENSG.
OrthoDBiEOG7FZ01C.
TreeFamiTF313182.

Family and domain databases

InterProiIPR011421. BCNT-C.
IPR027124. Swc5/CFDP.
[Graphical view]
PANTHERiPTHR23227. PTHR23227. 1 hit.
PfamiPF07572. BCNT. 1 hit.
[Graphical view]
PROSITEiPS51279. BCNT_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1."
    Iwashita S., Osada N., Itoh T., Sezaki M., Oshima K., Hashimoto E., Kitagawa-Arita Y., Takahashi I., Masui T., Hashimoto K., Makalowski W.
    Mol. Biol. Evol. 20:1556-1563(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, GENE DUPLICATION.
    Strain: Jersey.
    Tissue: Kidney.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: Hereford.
    Tissue: Testis.

Entry informationi

Entry nameiCFDP1_BOVIN
AccessioniPrimary (citable) accession number: Q8HXY9
Secondary accession number(s): Q2KIY4, Q8I031, Q8I033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Gene duplication of the ancestral BCNT gene leads to the h-type BCNT (CFDP1) gene and the p97BCNT (CFDP2) gene. The latter contains a region derived from the endonuclease domain of a retrotransposable element RTE-1. This repetitive sequence associated with the BCNT gene is specific to Ruminantia.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.