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Q8HXY8

- ACADM_MACFA

UniProt

Q8HXY8 - ACADM_MACFA

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Protein
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Gene
ACADM, QtrA-12403
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This enzyme is specific for acyl chain lengths of 4 to 16 By similarity.

Catalytic activityi

A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei167 – 1671Substrate; via carbonyl oxygen By similarity
Binding sitei216 – 2161Substrate By similarity
Active sitei401 – 4011Proton acceptor By similarity
Binding sitei402 – 4021Substrate; via amide nitrogen By similarity
Binding sitei413 – 4131Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi158 – 16710FAD By similarity
Nucleotide bindingi191 – 1933FAD By similarity
Nucleotide bindingi306 – 3083FAD By similarity
Nucleotide bindingi316 – 3172FAD By similarity
Nucleotide bindingi374 – 3785FAD By similarity
Nucleotide bindingi403 – 4053FAD By similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: UniProtKB
  2. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00660.

Names & Taxonomyi

Protein namesi
Recommended name:
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (EC:1.3.8.7)
Short name:
MCAD
Gene namesi
Name:ACADM
ORF Names:QtrA-12403
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2525Mitochondrion By similarity
Add
BLAST
Chaini26 – 421396Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
PRO_0000000503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei69 – 691N6-acetyllysine; alternate By similarity
Modified residuei69 – 691N6-succinyllysine; alternate By similarity
Modified residuei179 – 1791N6-succinyllysine By similarity
Modified residuei212 – 2121N6-acetyllysine; alternate By similarity
Modified residuei212 – 2121N6-succinyllysine; alternate By similarity
Modified residuei217 – 2171N6-acetyllysine; alternate By similarity
Modified residuei217 – 2171N6-succinyllysine; alternate By similarity
Modified residuei259 – 2591N6-acetyllysine; alternate By similarity
Modified residuei259 – 2591N6-succinyllysine; alternate By similarity
Modified residuei271 – 2711N6-acetyllysine; alternate By similarity
Modified residuei271 – 2711N6-succinyllysine; alternate By similarity
Modified residuei279 – 2791N6-acetyllysine By similarity
Modified residuei301 – 3011N6-acetyllysine By similarity

Post-translational modificationi

Acetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity. These sites are deacetylated by SIRT3 By similarity.

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ8HXY8.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8HXY8.
SMRiQ8HXY8. Positions 35-420.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni278 – 2814Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG000224.

Family and domain databases

Gene3Di1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProiIPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEiPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HXY8-1 [UniParc]FASTAAdd to Basket

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MAAAFGRCCR VLRSISRFHW RSQHTKADRQ REPGLGFSFE FTEQQKEFQA    50
TARKFAREEI IPVAAEYDKT GEYPVPLIRR AWELGLMNPH IPQNCGGLGL 100
GTFDACLISE ELAYGCTGVQ TAIEGNSLGQ MPIIIAGNEQ QKKKYLGRMT 150
EEPLMCAYCV TEPGAGSDVA GIKTKAEKKG DEYIINGQKM WITNGGKASW 200
YFLLARSDPD PKAPANKAFT GFIVEADTPG IQIGRKELNM GQRCSDTRGI 250
VFEDVKVLKE NVLIGDGAGF KIAMGAFDKT RPTVSSGAVG LAQRALDEAT 300
KYALERKTFG KLLIEHQAIS FMLAEMAMKV ELARMSYQRA AWEVDSGRRN 350
TYYASIAKAF AGDIANQLAT DAVQIFGGNG FNTEYPVEKL MRDAKIYQIY 400
EGTSQIQRLI IAREHIGKYK S 421
Length:421
Mass (Da):46,626
Last modified:March 1, 2003 - v1
Checksum:iDDA2F825B5AF9CC0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083301 mRNA. Translation: BAC20580.1.
UniGeneiMfa.707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083301 mRNA. Translation: BAC20580.1 .
UniGenei Mfa.707.

3D structure databases

ProteinModelPortali Q8HXY8.
SMRi Q8HXY8. Positions 35-420.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8HXY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG000224.

Enzyme and pathway databases

UniPathwayi UPA00660 .

Family and domain databases

Gene3Di 1.10.540.10. 1 hit.
2.40.110.10. 1 hit.
InterProi IPR006089. Acyl-CoA_DH_CS.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view ]
Pfami PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47203. SSF47203. 1 hit.
SSF56645. SSF56645. 1 hit.
PROSITEi PS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of cDNA for macaque neurological disease genes."
    Kusuda J., Osada N., Hida M., Sugano S., Hashimoto K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Temporal cortex.

Entry informationi

Entry nameiACADM_MACFA
AccessioniPrimary (citable) accession number: Q8HXY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: March 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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