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Q8HXY7 (ACADV_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Short name=VLCAD
EC=1.3.99.-
Gene names
Name:ACADVL
Synonyms:VLCAD
ORF Names:QccE-11706
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length655 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accomodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons By similarity.

Catalytic activity

Acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.

Cofactor

FAD.

Pathway

Lipid metabolism; mitochondrial fatty acid beta-oxidation.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion inner membrane.

Miscellaneous

A number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4040Mitochondrion By similarity
Chain41 – 655615Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
PRO_0000000516

Regions

Nucleotide binding214 – 22310FAD By similarity
Nucleotide binding249 – 2513FAD By similarity
Nucleotide binding435 – 4395FAD By similarity
Nucleotide binding464 – 4663FAD By similarity
Region41 – 482442Catalytic
Region338 – 3414Substrate binging By similarity
Region462 – 4632Substrate binding By similarity
Region483 – 51634Membrane-anchoring Probable

Sites

Active site4621Proton acceptor By similarity
Binding site2231Substrate; via carbonyl oxygen By similarity
Binding site3661FAD By similarity
Binding site4631Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue2391N6-acetyllysine By similarity
Modified residue2761N6-acetyllysine By similarity
Modified residue3311N6-acetyllysine By similarity
Cross-link331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8HXY7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: DCC7AA898EFCB333

FASTA65570,443
        10         20         30         40         50         60 
MQAARIAPSL GRQLLRFGGG SSRPTALLGQ PWPGPARRPY AGGAAQLALD KSDSHLSDAL 

        70         80         90        100        110        120 
NKAKPAKAES KSFAVAMFKG QLTTDQVFPY PSVLNQEQTE FLKELVEPVS RFFEEVNDPA 

       130        140        150        160        170        180 
KNDTLEMVEE TTLQGLKELG AFGLQVPSEL GGVGLCNTQY ARLVEIVGMH DLAVGITLGA 

       190        200        210        220        230        240 
HQSIGFKGIL LFGTKAQKEK YLPKLASGET LAAFCLTEPS SGSDAASIRT SAVPSPCGKY 

       250        260        270        280        290        300 
YTLNGSKLWI SNGGLADIFT VFAKTPVTDP ATGAVKEKIT AFVVERGFGG VTHGPPEKKM 

       310        320        330        340        350        360 
GIKASNTAEV LFDGVRVPSE NVLGEVGSGF KVAMHILNNG RFGMAAALAG TMRGIITKAV 

       370        380        390        400        410        420 
DYATNRIQFG EKIHNFGLIQ EKLARMVMLQ YVTESMAYMV SANMDQGSTD FQIEAAISKI 

       430        440        450        460        470        480 
FGSEAAWKVT DECIQIMGGM GFMKEPGVER VLRDLRIFRI FEGTNDILRL FVALQGCMDK 

       490        500        510        520        530        540 
GKELSGLGSA LKNPFGNAGL LLGEAGKQLR RRAGLGSGLS LSGIVHPELS RSGELAVQAL 

       550        560        570        580        590        600 
EQFATVVEAK LIKHKKGIVN EQFLLQRLAD GAIDLYAMVV VLSRASRSLS EGHHTAQHEK 

       610        620        630        640        650 
MLCDTWCIEA AARIREGMAA LQSDPRQHEL YRNFKSISKA LVERGGVVTN NPLGF

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References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Hida M., Sugano S., Hashimoto K.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB083302 mRNA. Translation: BAC20581.1.

3D structure databases

ProteinModelPortalQ8HXY7.
SMRQ8HXY7. Positions 69-655.
ModBaseSearch...

Proteomic databases

PRIDEQ8HXY7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050448.

Family and domain databases

InterProIPR006089. Acyl-CoA_DH_CS.
IPR006092. Acyl-CoA_DH_N.
IPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
SUPFAMSSF56645. AcylCoA_dehyd_NM. 1 hit.
SSF47203. AcylCoADH_C_like. 1 hit.
PROSITEPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACADV_MACFA
AccessionPrimary (citable) accession number: Q8HXY7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2003
Last modified: October 19, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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