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Reviewed, UniProtKB/Swiss-Prot Q8HXX8 (GCDH_MACFA)

Last modified January 19, 2010. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glutaryl-CoA dehydrogenase, mitochondrial
      Short name=GCD
    EC=1.3.99.7
Gene names
Name: GCDH
ORF Names: QccE-20069
OrganismMacaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

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Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO2 in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor By similarity.

Catalytic activity

Glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor.

Cofactor

FAD By similarity.

Pathway

Amino-acid metabolism; lysine degradation.

Amino-acid metabolism; tryptophan metabolism.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

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Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentmitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

glutaryl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4444Mitochondrion Potential
Chain45 – 438394Glutaryl-CoA dehydrogenase, mitochondrial
PRO_0000000527

Regions

Nucleotide binding177 – 18610FAD By similarity
Nucleotide binding177 – 1804FAD By similarity
Nucleotide binding212 – 2143FAD By similarity
Nucleotide binding387 – 3915FAD By similarity
Nucleotide binding416 – 4183FAD By similarity
Region138 – 1392Substrate binding By similarity
Region287 – 2948Substrate binding By similarity

Sites

Active site4141Proton acceptor By similarity
Binding site1861FAD By similarity
Binding site1861Substrate; via carbonyl oxygen By similarity
Binding site2941Substrate By similarity
Binding site3191FAD By similarity
Binding site3301FAD By similarity
Binding site4151Substrate; via amide nitrogen By similarity
Binding site4161FAD By similarity
Binding site4341FAD; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q8HXX8-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7220D91CD65F263E

FASTA43848,382
        10         20         30         40         50         60 
MALRGVSVQL LSRVPGLRVF RTWVSSAAQT EKVGRTQSQL AKSSRPEFDW RDPLVLEEQL 

        70         80         90        100        110        120 
TTDEILIRDT FRTYCQERLM PRILLANRNE VFHREIISQM GELGVLGPTI KGYGCAGVSS 

       130        140        150        160        170        180 
VAYGLLAREL ERVDSGYRSA MSVQSPLVMH PIYAYGSEEQ RQKYLPRLAK GELLGCFGLT 

       190        200        210        220        230        240 
EPNSGSDPSS METRARYNSS NKSYTLNGTK TWITNSPMAD LFVVWARCED GRIRGFLLEK 

       250        260        270        280        290        300 
GMRGLSAPRI QGKFSLRASA TGMIIMDGVE VPEENMLPGA SSLGGSFGCL NNGRYGIAWG 

       310        320        330        340        350        360 
VLGASEFCLH TARQYALDRM QFGVPLARNQ LIQKKLADML TEITLGLHAC LQLGRLKDQD 

       370        380        390        400        410        420 
KAAPEMVSLL KRNNCGKALD IARQARDMLG GNGISDEYHV IRHAMNLEAV NTYEGTHDIH 

       430 
ALILGRAITG IQAFTASK

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References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Hida M., Sugano S., Hashimoto K.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB083311 mRNA. Translation: BAC20590.1.

3D structure databases

SMRQ8HXX8. Positions 47-436.
ModBaseSearch...

Phylogenomic databases

HOVERGENQ8HXX8.

Enzyme and pathway databases

BRENDA1.3.99.7. 3438.

Family and domain databases

InterProIPR006089. Acyl-CoA_DH_CS.
IPR006092. Acyl-CoA_DH_N.
IPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR009075. AcylCo_DH/oxidase_C.
IPR013786. AcylCoA_DH/ox_N.
IPR009100. AcylCoA_DH/oxidase.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 1 hit.
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
PF02771. Acyl-CoA_dh_N. 1 hit.
[Graphical view]
PROSITEPS00072. ACYL_COA_DH_1. 1 hit.
PS00073. ACYL_COA_DH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGCDH_MACFA
AccessionPrimary (citable) accession number: Q8HXX8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: January 19, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents