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Q8HXW3

- SDHA_MACFA

UniProt

Q8HXW3 - SDHA_MACFA

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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene
SDHA, QccE-14114
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity. Can act as a tumor suppressor By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei275 – 2751FAD By similarity
Binding sitei296 – 2961Substrate By similarity
Binding sitei308 – 3081Substrate By similarity
Active sitei340 – 3401Proton acceptor By similarity
Binding sitei407 – 4071Substrate By similarity
Binding sitei440 – 4401FAD By similarity
Binding sitei451 – 4511Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi68 – 736FAD By similarity
Nucleotide bindingi91 – 10616FAD By similarityAdd
BLAST
Nucleotide bindingi456 – 4572FAD By similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. oxidation-reduction process Source: UniProtKB
  2. respiratory electron transport chain Source: UniProtKB
  3. succinate metabolic process Source: UniProtKB
  4. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II
Short name:
Fp
Gene namesi
Name:SDHA
ORF Names:QccE-14114
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial respiratory chain complex II Source: UniProtKB
  3. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343Mitochondrion By similarityAdd
BLAST
Chaini44 – 664621Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei99 – 991Tele-8alpha-FAD histidine By similarity
Modified residuei167 – 1671N6-acetyllysine By similarity
Modified residuei179 – 1791N6-acetyllysine; alternate By similarity
Modified residuei179 – 1791N6-succinyllysine; alternate By similarity
Modified residuei182 – 1821N6-acetyllysine By similarity
Modified residuei215 – 2151Phosphotyrosine; by SRC By similarity
Modified residuei250 – 2501N6-acetyllysine; alternate By similarity
Modified residuei250 – 2501N6-succinyllysine; alternate By similarity
Modified residuei335 – 3351N6-acetyllysine; alternate By similarity
Modified residuei335 – 3351N6-succinyllysine; alternate By similarity
Modified residuei480 – 4801N6-acetyllysine By similarity
Modified residuei485 – 4851N6-acetyllysine; alternate By similarity
Modified residuei485 – 4851N6-succinyllysine; alternate By similarity
Modified residuei498 – 4981N6-acetyllysine; alternate By similarity
Modified residuei498 – 4981N6-succinyllysine; alternate By similarity
Modified residuei517 – 5171N6-acetyllysine By similarity
Modified residuei538 – 5381N6-acetyllysine; alternate By similarity
Modified residuei538 – 5381N6-succinyllysine; alternate By similarity
Modified residuei541 – 5411N6-acetyllysine By similarity
Modified residuei547 – 5471N6-acetyllysine; alternate By similarity
Modified residuei547 – 5471N6-succinyllysine; alternate By similarity
Modified residuei550 – 5501N6-acetyllysine By similarity
Modified residuei598 – 5981N6-acetyllysine By similarity
Modified residuei608 – 6081N6-acetyllysine By similarity
Modified residuei615 – 6151N6-succinyllysine By similarity
Modified residuei624 – 6241N6-acetyllysine By similarity
Modified residuei636 – 6361N6-acetyllysine By similarity
Modified residuei647 – 6471N6-acetyllysine By similarity

Post-translational modificationi

Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation By similarity.
Deacetylated by SIRT3 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ8HXW3.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. Interacts with TRAP1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8HXW3.
SMRiQ8HXW3. Positions 52-664.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001461.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HXW3-1 [UniParc]FASTAAdd to Basket

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MSGVRRLSRL LSTRRLALAK AWPAVLQTGT RGFHFTVDGN KRASAKVSDS    50
ISAQYPVVDH EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT 100
VAAQGGINAA LGNMEEDNWR WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV 150
VELENYGMPF SRTEDGKIYQ RAFGGQSLKF GKGGQAHRCC CVADRTGHSL 200
LHTLYGRSLR YDTSYFVEYF ALDLLMENRE CRGVIALCIE DGSIHRIRAK 250
NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI 300
YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE 350
IREGRGCGPE KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI 400
PVLPTVHYNM GGIPTNYKGQ VLRHVNGQDQ IVPGLYACGE AACASVHGAN 450
RLGANSLWDL VVFGRACALS IEESCRPGDK VPPIKPNAGE ESVMNLDKLR 500
FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS KLYGDLKHLK 550
TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKAR 600
IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVSTGKVTLE YRPVIDKTLN 650
EADCATVPPA IRSY 664
Length:664
Mass (Da):72,965
Last modified:March 1, 2003 - v1
Checksum:i181C2C8E463DF802
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083328 mRNA. Translation: BAC20607.1.
UniGeneiMfa.1914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB083328 mRNA. Translation: BAC20607.1 .
UniGenei Mfa.1914.

3D structure databases

ProteinModelPortali Q8HXW3.
SMRi Q8HXW3. Positions 52-664.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8HXW3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG001461.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of cDNA for macaque neurological disease genes."
    Kusuda J., Osada N., Hida M., Sugano S., Hashimoto K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain cortex.

Entry informationi

Entry nameiSDHA_MACFA
AccessioniPrimary (citable) accession number: Q8HXW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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