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Q8HXW3 (SDHA_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Flavoprotein subunit of complex II
Short name=Fp
Gene names
Name:SDHA
ORF Names:QccE-14114
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length664 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity. Can act as a tumor suppressor By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

FAD By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. Interacts with TRAP1 By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Post-translational modification

Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation By similarity.

Deacetylated by SIRT3 By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4343Mitochondrion By similarity
Chain44 – 664621Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
PRO_0000010336

Regions

Nucleotide binding68 – 736FAD By similarity
Nucleotide binding91 – 10616FAD By similarity
Nucleotide binding456 – 4572FAD By similarity

Sites

Active site3401Proton acceptor By similarity
Binding site2751FAD By similarity
Binding site2961Substrate By similarity
Binding site3081Substrate By similarity
Binding site4071Substrate By similarity
Binding site4401FAD By similarity
Binding site4511Substrate By similarity

Amino acid modifications

Modified residue991Tele-8alpha-FAD histidine By similarity
Modified residue1671N6-acetyllysine By similarity
Modified residue1791N6-acetyllysine; alternate By similarity
Modified residue1791N6-succinyllysine; alternate By similarity
Modified residue1821N6-acetyllysine By similarity
Modified residue2151Phosphotyrosine; by SRC By similarity
Modified residue2501N6-acetyllysine; alternate By similarity
Modified residue2501N6-succinyllysine; alternate By similarity
Modified residue3351N6-acetyllysine; alternate By similarity
Modified residue3351N6-succinyllysine; alternate By similarity
Modified residue4801N6-acetyllysine By similarity
Modified residue4851N6-acetyllysine; alternate By similarity
Modified residue4851N6-succinyllysine; alternate By similarity
Modified residue4981N6-acetyllysine; alternate By similarity
Modified residue4981N6-succinyllysine; alternate By similarity
Modified residue5171N6-acetyllysine By similarity
Modified residue5381N6-acetyllysine; alternate By similarity
Modified residue5381N6-succinyllysine; alternate By similarity
Modified residue5411N6-acetyllysine By similarity
Modified residue5471N6-acetyllysine; alternate By similarity
Modified residue5471N6-succinyllysine; alternate By similarity
Modified residue5501N6-acetyllysine By similarity
Modified residue5981N6-acetyllysine By similarity
Modified residue6081N6-acetyllysine By similarity
Modified residue6151N6-succinyllysine By similarity
Modified residue6241N6-acetyllysine By similarity
Modified residue6361N6-acetyllysine By similarity
Modified residue6471N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8HXW3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 181C2C8E463DF802

FASTA66472,965
        10         20         30         40         50         60 
MSGVRRLSRL LSTRRLALAK AWPAVLQTGT RGFHFTVDGN KRASAKVSDS ISAQYPVVDH 

        70         80         90        100        110        120 
EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT VAAQGGINAA LGNMEEDNWR 

       130        140        150        160        170        180 
WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV VELENYGMPF SRTEDGKIYQ RAFGGQSLKF 

       190        200        210        220        230        240 
GKGGQAHRCC CVADRTGHSL LHTLYGRSLR YDTSYFVEYF ALDLLMENRE CRGVIALCIE 

       250        260        270        280        290        300 
DGSIHRIRAK NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI 

       310        320        330        340        350        360 
YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE IREGRGCGPE 

       370        380        390        400        410        420 
KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI PVLPTVHYNM GGIPTNYKGQ 

       430        440        450        460        470        480 
VLRHVNGQDQ IVPGLYACGE AACASVHGAN RLGANSLWDL VVFGRACALS IEESCRPGDK 

       490        500        510        520        530        540 
VPPIKPNAGE ESVMNLDKLR FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS 

       550        560        570        580        590        600 
KLYGDLKHLK TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKAR 

       610        620        630        640        650        660 
IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVSTGKVTLE YRPVIDKTLN EADCATVPPA 


IRSY 

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References

[1]"Isolation and characterization of cDNA for macaque neurological disease genes."
Kusuda J., Osada N., Hida M., Sugano S., Hashimoto K.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB083328 mRNA. Translation: BAC20607.1.
UniGeneMfa.1914.

3D structure databases

ProteinModelPortalQ8HXW3.
SMRQ8HXW3. Positions 52-664.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8HXW3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG001461.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHA_MACFA
AccessionPrimary (citable) accession number: Q8HXW3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways