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Q8HXW3

- SDHA_MACFA

UniProt

Q8HXW3 - SDHA_MACFA

Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDHA

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei275 – 2751FADBy similarity
    Binding sitei296 – 2961SubstrateBy similarity
    Binding sitei308 – 3081SubstrateBy similarity
    Active sitei340 – 3401Proton acceptorBy similarity
    Binding sitei407 – 4071SubstrateBy similarity
    Binding sitei440 – 4401FADBy similarity
    Binding sitei451 – 4511SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi68 – 736FADBy similarity
    Nucleotide bindingi91 – 10616FADBy similarityAdd
    BLAST
    Nucleotide bindingi456 – 4572FADBy similarity

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. oxidation-reduction process Source: UniProtKB
    2. respiratory electron transport chain Source: UniProtKB
    3. succinate metabolic process Source: UniProtKB
    4. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Flavoprotein subunit of complex II
    Short name:
    Fp
    Gene namesi
    Name:SDHA
    ORF Names:QccE-14114
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB
    3. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4343MitochondrionBy similarityAdd
    BLAST
    Chaini44 – 664621Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialPRO_0000010336Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei99 – 991Tele-8alpha-FAD histidineBy similarity
    Modified residuei167 – 1671N6-acetyllysineBy similarity
    Modified residuei179 – 1791N6-acetyllysine; alternateBy similarity
    Modified residuei179 – 1791N6-succinyllysine; alternateBy similarity
    Modified residuei182 – 1821N6-acetyllysineBy similarity
    Modified residuei215 – 2151Phosphotyrosine; by SRCBy similarity
    Modified residuei250 – 2501N6-acetyllysine; alternateBy similarity
    Modified residuei250 – 2501N6-succinyllysine; alternateBy similarity
    Modified residuei335 – 3351N6-acetyllysine; alternateBy similarity
    Modified residuei335 – 3351N6-succinyllysine; alternateBy similarity
    Modified residuei480 – 4801N6-acetyllysineBy similarity
    Modified residuei485 – 4851N6-acetyllysine; alternateBy similarity
    Modified residuei485 – 4851N6-succinyllysine; alternateBy similarity
    Modified residuei498 – 4981N6-acetyllysine; alternateBy similarity
    Modified residuei498 – 4981N6-succinyllysine; alternateBy similarity
    Modified residuei517 – 5171N6-acetyllysineBy similarity
    Modified residuei538 – 5381N6-acetyllysine; alternateBy similarity
    Modified residuei538 – 5381N6-succinyllysine; alternateBy similarity
    Modified residuei541 – 5411N6-acetyllysineBy similarity
    Modified residuei547 – 5471N6-acetyllysine; alternateBy similarity
    Modified residuei547 – 5471N6-succinyllysine; alternateBy similarity
    Modified residuei550 – 5501N6-acetyllysineBy similarity
    Modified residuei598 – 5981N6-acetyllysineBy similarity
    Modified residuei608 – 6081N6-acetyllysineBy similarity
    Modified residuei615 – 6151N6-succinyllysineBy similarity
    Modified residuei624 – 6241N6-acetyllysineBy similarity
    Modified residuei636 – 6361N6-acetyllysineBy similarity
    Modified residuei647 – 6471N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation.By similarity
    Deacetylated by SIRT3.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ8HXW3.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. Interacts with SDHAF2/SDH5; interaction is required for FAD attachment By similarity. Interacts with TRAP1 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HXW3.
    SMRiQ8HXW3. Positions 52-664.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG001461.

    Family and domain databases

    Gene3Di1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProiIPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view]
    PfamiPF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8HXW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGVRRLSRL LSTRRLALAK AWPAVLQTGT RGFHFTVDGN KRASAKVSDS    50
    ISAQYPVVDH EFDAVVVGAG GAGLRAAFGL SEAGFNTACV TKLFPTRSHT 100
    VAAQGGINAA LGNMEEDNWR WHFYDTVKGS DWLGDQDAIH YMTEQAPAAV 150
    VELENYGMPF SRTEDGKIYQ RAFGGQSLKF GKGGQAHRCC CVADRTGHSL 200
    LHTLYGRSLR YDTSYFVEYF ALDLLMENRE CRGVIALCIE DGSIHRIRAK 250
    NTVVATGGYG RTYFSCTSAH TSTGDGTAMI TRAGLPCQDL EFVQFHPTGI 300
    YGAGCLITEG CRGEGGILIN SQGERFMERY APVAKDLASR DVVSRSMTLE 350
    IREGRGCGPE KDHVYLQLHH LPPEQLATRL PGISETAMIF AGVDVTKEPI 400
    PVLPTVHYNM GGIPTNYKGQ VLRHVNGQDQ IVPGLYACGE AACASVHGAN 450
    RLGANSLWDL VVFGRACALS IEESCRPGDK VPPIKPNAGE ESVMNLDKLR 500
    FADGSIRTSE LRLSMQKSMQ NHAAVFRVGS VLQEGCGKIS KLYGDLKHLK 550
    TFDRGMVWNT DLVETLELQN LMLCALQTIY GAEARKESRG AHAREDYKAR 600
    IDEYDYSKPI QGQQKKPFEE HWRKHTLSYV DVSTGKVTLE YRPVIDKTLN 650
    EADCATVPPA IRSY 664
    Length:664
    Mass (Da):72,965
    Last modified:March 1, 2003 - v1
    Checksum:i181C2C8E463DF802
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083328 mRNA. Translation: BAC20607.1.
    UniGeneiMfa.1914.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB083328 mRNA. Translation: BAC20607.1 .
    UniGenei Mfa.1914.

    3D structure databases

    ProteinModelPortali Q8HXW3.
    SMRi Q8HXW3. Positions 52-664.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8HXW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG001461.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .

    Family and domain databases

    Gene3Di 1.20.58.100. 1 hit.
    3.90.700.10. 1 hit.
    InterProi IPR003953. FAD_bind_dom.
    IPR003952. FRD_SDH_FAD_BS.
    IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
    IPR027477. Succ_DH/fumarate_Rdtase_cat.
    IPR011281. Succ_DH_flav_su_fwd.
    IPR014006. Succ_Dhase_FrdA_Gneg.
    [Graphical view ]
    Pfami PF00890. FAD_binding_2. 1 hit.
    PF02910. Succ_DH_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46977. SSF46977. 1 hit.
    SSF56425. SSF56425. 1 hit.
    TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
    TIGR01812. sdhA_frdA_Gneg. 1 hit.
    PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNA for macaque neurological disease genes."
      Kusuda J., Osada N., Hida M., Sugano S., Hashimoto K.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiSDHA_MACFA
    AccessioniPrimary (citable) accession number: Q8HXW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3