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Protein

Calcium-binding mitochondrial carrier protein Aralar2

Gene

SLC25A13

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle (By similarity).By similarity

Miscellaneous

Binds calcium.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi66 – 771Add BLAST12
Calcium bindingi100 – 1112Add BLAST12
Calcium bindingi171 – 1823Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein Aralar2
Alternative name(s):
Citrin
Mitochondrial aspartate glutamate carrier 2
Solute carrier family 25 member 13
Gene namesi
Name:SLC25A13
Synonyms:ARALAR2
ORF Names:QflA-10133
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei332 – 349Helical; Name=1Sequence analysisAdd BLAST18
Transmembranei393 – 412Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei436 – 449Helical; Name=3Sequence analysisAdd BLAST14
Transmembranei485 – 504Helical; Name=4Sequence analysisAdd BLAST20
Transmembranei524 – 541Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei581 – 600Helical; Name=6Sequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000906012 – 674Calcium-binding mitochondrial carrier protein Aralar2Add BLAST673

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei353N6-acetyllysineBy similarity1
Modified residuei372N6-acetyllysineBy similarity1
Modified residuei453N6-methyllysineBy similarity1
Modified residuei484N6-acetyllysine; alternateBy similarity1
Modified residuei484N6-succinyllysine; alternateBy similarity1
Modified residuei580N6-succinyllysineBy similarity1
Modified residuei661N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PRIDEiQ8HXW2.

Structurei

3D structure databases

ProteinModelPortaliQ8HXW2.
SMRiQ8HXW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 86EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini87 – 122EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini123 – 157EF-hand 3PROSITE-ProRule annotationAdd BLAST35
Domaini158 – 193EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Repeati326 – 418Solcar 1Add BLAST93
Repeati426 – 510Solcar 2Add BLAST85
Repeati518 – 605Solcar 3Add BLAST88

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG005350.
KOiK15105.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
SSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 2 hits.
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HXW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAKVALTK RADPAELRTI FLKYASIEKN GEFFTSPNDF VTRYLNIFGE
60 70 80 90 100
SQPNPKTVEL LSGVADQTKD GLISFQEFVA FESVLCAPDA LFMVAFQLFD
110 120 130 140 150
KAGKGEVTFE DVKQVFGQTT IHQHIPFNWD SEFVQLHFGK ERKRHLTYAE
160 170 180 190 200
FTQFLLEIQL EHAKQAFVQR DNASTGRVTA IDFRDIMVTI RPHVLTPFVE
210 220 230 240 250
ECLVAAAGGT TSHQVSFSYF NGFNSLLNNM ELTRKIYSTL AGNRKDVEVT
260 270 280 290 300
KEEFVLAAQK FGQVTPMEVD ILFRLADLYE PRGRMTLADI ERIAPLEEGT
310 320 330 340 350
LPFNLAEAQR QKASGDSARP VLLQVAESAY RFGLGSVAGA VGATAVYPID
360 370 380 390 400
LVKTRMQNQR STGSFVGELM YKNSFDCFKK VLRYEGFFGL YRGLLPQLLG
410 420 430 440 450
VAPEKAIKLT VNDFVRDKFM HKDGSVPLAA EILAGGCAGG SQVIFTNPLE
460 470 480 490 500
IVKIRLQVAG EITTGPRVSA LSVVRDLGFF GIYKGAKACF LRDIPFSAIY
510 520 530 540 550
FPCYAHARAS FANEDGQVSP GSLLLAGAIA GMPAASLVTP ADVIKTRLQV
560 570 580 590 600
AARAGQTTYS GVIDCFKKIL REEGPKALWK GAARVFRSSP QFGVTLLTYE
610 620 630 640 650
LLQRWFYIDF GGVKPMGSEP VPKSRINLPA PNPDHVGGYK LAVATFAGIE
660 670
NKFGLYLPLF KPSVPTSEAI GGGP
Length:674
Mass (Da):74,003
Last modified:March 1, 2003 - v1
Checksum:iCD01541BE5AB0EFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB083329 mRNA. Translation: BAC20608.1.
RefSeqiNP_001270156.1. NM_001283227.1.
UniGeneiMfa.2833.

Genome annotation databases

GeneIDi102115095.
KEGGimcf:102115095.

Similar proteinsi

Entry informationi

Entry nameiCMC2_MACFA
AccessioniPrimary (citable) accession number: Q8HXW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: May 10, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families