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Protein

Prolactin

Gene

PRL

Organism
Ailuropoda melanoleuca (Giant panda)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Prolactin acts primarily on the mammary gland by promoting lactation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processLactation

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiAiluropoda melanoleuca (Giant panda)
Taxonomic identifieri9646 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeAiluropoda
Proteomesi
  • UP000008912 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000003291031 – 229ProlactinAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 41By similarity
Modified residuei56PhosphoserineBy similarity1
Modified residuei64PhosphoserineBy similarity1
Disulfide bondi88 ↔ 204By similarity
Modified residuei120PhosphoserineBy similarity1
Disulfide bondi221 ↔ 229By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9646.ENSAMEP00000011769

Structurei

3D structure databases

ProteinModelPortaliQ8HXS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74 Eukaryota
ENOG410XU1S LUCA
GeneTreeiENSGT00730000110805
HOGENOMiHOG000264241
HOVERGENiHBG104895
InParanoidiQ8HXS1
KOiK05439
OMAiDSHKIDN
OrthoDBiEOG091G0O08
TreeFamiTF332592

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8HXS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKKGWSLKG SLLPLLLLVS DLLLCQSVAS LPICPTGAVN CQVSLRDLFD
60 70 80 90 100
RAVILSHYIH NLSSEMFNEF DKRYAQGRGF ITKAINSCHT SSLSTPEDKE
110 120 130 140 150
QAQQIHHEDL LNLILRVLRS WNDPLYHLVT EVRGMQEAPD SILSRAIEIE
160 170 180 190 200
EQNRRLLEGM EKIVGQVHPG VRENEVYSVW SGLPSLQMAD EDTRLFAFYN
210 220
LLHCLRRDSH KIDNYLKLLK CRIVYDSNC
Length:229
Mass (Da):26,236
Last modified:March 1, 2003 - v1
Checksum:i441E3D748CFDDBC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY161285 mRNA Translation: AAN78320.1
RefSeqiNP_001291863.1, NM_001304934.1

Genome annotation databases

EnsembliENSAMET00000012267; ENSAMEP00000011769; ENSAMEG00000011161
GeneIDi100481524
KEGGiaml:100481524

Similar proteinsi

Entry informationi

Entry nameiPRL_AILME
AccessioniPrimary (citable) accession number: Q8HXS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health