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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. May protect milk against xenobiotics. Hydrolyzes ATP with low efficiency (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi678 – 685ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1326 – 1333ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 54Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 95Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini96 – 100ExtracellularBy similarity5
Transmembranei101 – 121Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 172ExtracellularBy similarityAdd BLAST18
Transmembranei173 – 193Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini194 – 316CytoplasmicBy similarityAdd BLAST123
Transmembranei317 – 337Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini338 – 363ExtracellularBy similarityAdd BLAST26
Transmembranei364 – 384Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini385 – 440CytoplasmicBy similarityAdd BLAST56
Transmembranei441 – 461Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini462 – 464ExtracellularBy similarity3
Transmembranei465 – 485Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini486 – 547CytoplasmicBy similarityAdd BLAST62
Transmembranei548 – 568Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini569 – 590ExtracellularBy similarityAdd BLAST22
Transmembranei591 – 611Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini612 – 966CytoplasmicBy similarityAdd BLAST355
Transmembranei967 – 987Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini988 – 1024ExtracellularBy similarityAdd BLAST37
Transmembranei1025 – 1045Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1046 – 1088CytoplasmicBy similarityAdd BLAST43
Transmembranei1089 – 1109Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1110ExtracellularBy similarity1
Transmembranei1111 – 1131Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1132 – 1202CytoplasmicBy similarityAdd BLAST71
Transmembranei1203 – 1223Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1224 – 1225ExtracellularBy similarity2
Transmembranei1226 – 1246Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1247 – 1530CytoplasmicBy similarityAdd BLAST284

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933491 – 1530Multidrug resistance-associated protein 1Add BLAST1530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei277PhosphotyrosineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei503N6-succinyllysineBy similarity1
Modified residuei915PhosphoserineBy similarity1
Modified residuei930PhosphoserineBy similarity1
Glycosylationi1005N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8HXQ5
PRIDEiQ8HXQ5

Expressioni

Tissue specificityi

Expressed in heart, spleen, lung, kidney, skeletal muscle, mammary gland and weaker in brain and liver.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028094

Structurei

Secondary structure

11530
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni209 – 212Combined sources4
Helixi215 – 220Combined sources6
Helixi222 – 224Combined sources3
Helixi225 – 233Combined sources9
Helixi238 – 240Combined sources3
Beta strandi246 – 249Combined sources4
Helixi250 – 267Combined sources18
Helixi316 – 319Combined sources4
Helixi322 – 325Combined sources4
Helixi328 – 354Combined sources27
Beta strandi356 – 358Combined sources3
Helixi361 – 407Combined sources47
Helixi412 – 417Combined sources6
Helixi420 – 440Combined sources21
Helixi443 – 461Combined sources19
Helixi464 – 466Combined sources3
Helixi467 – 509Combined sources43
Helixi512 – 518Combined sources7
Helixi521 – 554Combined sources34
Helixi556 – 570Combined sources15
Helixi580 – 589Combined sources10
Turni590 – 592Combined sources3
Helixi593 – 597Combined sources5
Helixi599 – 620Combined sources22
Helixi627 – 629Combined sources3
Beta strandi642 – 657Combined sources16
Beta strandi663 – 671Combined sources9
Beta strandi673 – 679Combined sources7
Helixi684 – 690Combined sources7
Turni691 – 693Combined sources3
Beta strandi695 – 706Combined sources12
Beta strandi708 – 711Combined sources4
Beta strandi719 – 721Combined sources3
Helixi722 – 727Combined sources6
Helixi734 – 743Combined sources10
Helixi747 – 752Combined sources6
Beta strandi753 – 755Combined sources3
Beta strandi763 – 768Combined sources6
Helixi770 – 784Combined sources15
Beta strandi787 – 792Combined sources6
Beta strandi795 – 798Combined sources4
Helixi800 – 809Combined sources10
Beta strandi812 – 816Combined sources5
Beta strandi818 – 825Combined sources8
Helixi832 – 834Combined sources3
Beta strandi835 – 842Combined sources8
Beta strandi845 – 848Combined sources4
Helixi852 – 858Combined sources7
Helixi861 – 865Combined sources5
Helixi959 – 969Combined sources11
Helixi971 – 999Combined sources29
Beta strandi1005 – 1007Combined sources3
Helixi1008 – 1057Combined sources50
Helixi1060 – 1065Combined sources6
Helixi1068 – 1109Combined sources42
Helixi1112 – 1117Combined sources6
Helixi1118 – 1146Combined sources29
Helixi1148 – 1159Combined sources12
Helixi1161 – 1167Combined sources7
Helixi1170 – 1219Combined sources50
Beta strandi1221 – 1224Combined sources4
Helixi1226 – 1256Combined sources31
Helixi1258 – 1263Combined sources6
Helixi1264 – 1266Combined sources3
Beta strandi1267 – 1269Combined sources3
Turni1286 – 1288Combined sources3
Beta strandi1292 – 1298Combined sources7
Beta strandi1300 – 1305Combined sources6
Beta strandi1307 – 1309Combined sources3
Beta strandi1312 – 1316Combined sources5
Beta strandi1322 – 1326Combined sources5
Beta strandi1330 – 1332Combined sources3
Helixi1333 – 1339Combined sources7
Beta strandi1346 – 1354Combined sources9
Turni1357 – 1359Combined sources3
Helixi1362 – 1366Combined sources5
Beta strandi1368 – 1372Combined sources5
Beta strandi1380 – 1382Combined sources3
Helixi1383 – 1387Combined sources5
Helixi1395 – 1404Combined sources10
Helixi1408 – 1413Combined sources6
Beta strandi1414 – 1418Combined sources5
Turni1424 – 1427Combined sources4
Helixi1431 – 1445Combined sources15
Beta strandi1448 – 1454Combined sources7
Beta strandi1457 – 1459Combined sources3
Helixi1461 – 1474Combined sources14
Beta strandi1475 – 1483Combined sources9
Helixi1487 – 1490Combined sources4
Beta strandi1493 – 1504Combined sources12
Helixi1510 – 1516Combined sources7
Helixi1519 – 1527Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UJ9electron microscopy3.49A205-1530[»]
5UJAelectron microscopy3.34A205-1530[»]
6BHUelectron microscopy3.14A1-1530[»]
ProteinModelPortaliQ8HXQ5
SMRiQ8HXQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 608ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini644 – 868ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini974 – 1255ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1292 – 1526ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi915 – 921Poly-Ser7

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
HOVERGENiHBG108314
InParanoidiQ8HXQ5
KOiK05665

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR005292 Multidrug-R_assoc
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
TIGRFAMsiTIGR00957 MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q8HXQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRDFCSVD GSDLFWEWNV TWNTSNPDFT KCFQNTVLVW VPCSYLWVCF
60 70 80 90 100
PFYFLYLSHH DRGYIQMTHL NKAKTALGFL LWIVCWADLF YSFWERSMGK
110 120 130 140 150
LLAPVFLVSP TLLGITMLLA TFLIQIERRR GVQSSGIMLT FWLIALLCAL
160 170 180 190 200
AILRSKIMTA LKEDARVDVF RDVTFYIYFS LVLIQLVLSC FSDRSPLFSE
210 220 230 240 250
TINDPNPCPE SSASFLSRIT FWWITGMMVQ GYRQPLESTD LWSLNKEDTS
260 270 280 290 300
EQVVPVLVKN WKKECAKSRK QPVKIVYSSK DPAKPKGSSK VDVNEEAEAL
310 320 330 340 350
IVKCPQKERD PSLFKVLYKT FGPYFLMSFL FKAVHDLMMF AGPEILKLLI
360 370 380 390 400
NFVNDKKAPE WQGYFYTALL FISACLQTLV LHQYFHICFV SGMRIKTAVI
410 420 430 440 450
GAVYRKALVI TNAARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ
460 470 480 490 500
VILALYLLWL NLGPSVLAGV AVMVLMVPLN AVMAMKTKTY QVAHMKSKDN
510 520 530 540 550
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLAAVGT
560 570 580 590 600
FTWVCTPFLV ALSTFAVYVT VDENNILDAQ KAFVSLALFN ILRFPLNILP
610 620 630 640 650
MVISSIVQAS VSLKRLRVFL SHEDLDPDSI QRRPIKDAGA TNSITVKNAT
660 670 680 690 700
FTWARNDPPT LHGITFSVPE GSLVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVTVKGSVAY VPQQAWIQNI SLRENILFGR QLQERYYKAV VEACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYCDSDVYL LDDPLSAVDA
810 820 830 840 850
HVGKHIFENV IGPKGLLKNK TRLLVTHAIS YLPQMDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLARDG AFAEFLRTYA SAEQEQGQPE DGLAGVGGPG KEVKQMENGM
910 920 930 940 950
LVTDTAGKQM QRQLSSSSSY SRDVSQHHTS TAELRKPGPT EETWKLVEAD
960 970 980 990 1000
KAQTGQVKLS VYWDYMKAIG LFISFLSIFL FLCNHVASLV SNYWLSLWTD
1010 1020 1030 1040 1050
DPIVNGTQEH TQVRLSVYGA LGISQGITVF GYSMAVSIGG IFASRRLHLD
1060 1070 1080 1090 1100
LLHNVLRSPI SFFERTPSGN LVNRFSKELD TVDSMIPQVI KMFMGSLFNV
1110 1120 1130 1140 1150
IGACIIILLA TPMAAVIIPP LGLIYFFVQR FYVASSRQLK RLESVSRSPV
1160 1170 1180 1190 1200
YSHFNETLLG VSVIRAFEEQ ERFIRQSDLK VDENQKAYYP SIVANRWLAV
1210 1220 1230 1240 1250
RLECVGNCIV LFASLFAVIS RHSLSAGLVG LSVSYSLQVT TYLNWLVRMS
1260 1270 1280 1290 1300
SEMETNIVAV ERLKEYSETE KEAPWQIQDM APPKDWPQVG RVEFRDYGLR
1310 1320 1330 1340 1350
YREDLDLVLK HINVTIDGGE KVGIVGRTGA GKSSLTLGLF RIKESAEGEI
1360 1370 1380 1390 1400
IIDDINIAKI GLHDLRFKIT IIPQDPVLFS GSLRMNLDPF SQYSDEEVWT
1410 1420 1430 1440 1450
SLELAHLKGF VSALPDKLNH ECAEGGENLS VGQRQLVCLA RALLRKTKIL
1460 1470 1480 1490 1500
VLDEATAAVD LETDDLIQST IRTQFDDCTV LTIAHRLNTI MDYTRVIVLD
1510 1520 1530
KGEIQEWGSP SDLLQQRGLF YSMAKDSGLV
Length:1,530
Mass (Da):171,666
Last modified:March 1, 2003 - v1
Checksum:iAAE4F92ED7832703
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082124 mRNA Translation: BAC15550.1
RefSeqiNP_776648.1, NM_174223.1
UniGeneiBt.88646

Genome annotation databases

GeneIDi281588
KEGGibta:281588

Similar proteinsi

Entry informationi

Entry nameiMRP1_BOVIN
AccessioniPrimary (citable) accession number: Q8HXQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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