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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. May protect milk against xenobiotics. Hydrolyzes ATP with low efficiency (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi678 – 685ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1326 – 1333ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 54Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 95Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini96 – 100ExtracellularBy similarity5
Transmembranei101 – 121Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 172ExtracellularBy similarityAdd BLAST18
Transmembranei173 – 193Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini194 – 316CytoplasmicBy similarityAdd BLAST123
Transmembranei317 – 337Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini338 – 363ExtracellularBy similarityAdd BLAST26
Transmembranei364 – 384Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini385 – 440CytoplasmicBy similarityAdd BLAST56
Transmembranei441 – 461Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini462 – 464ExtracellularBy similarity3
Transmembranei465 – 485Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini486 – 547CytoplasmicBy similarityAdd BLAST62
Transmembranei548 – 568Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini569 – 590ExtracellularBy similarityAdd BLAST22
Transmembranei591 – 611Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini612 – 966CytoplasmicBy similarityAdd BLAST355
Transmembranei967 – 987Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini988 – 1024ExtracellularBy similarityAdd BLAST37
Transmembranei1025 – 1045Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1046 – 1088CytoplasmicBy similarityAdd BLAST43
Transmembranei1089 – 1109Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1110ExtracellularBy similarity1
Transmembranei1111 – 1131Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1132 – 1202CytoplasmicBy similarityAdd BLAST71
Transmembranei1203 – 1223Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1224 – 1225ExtracellularBy similarity2
Transmembranei1226 – 1246Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1247 – 1530CytoplasmicBy similarityAdd BLAST284

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933491 – 1530Multidrug resistance-associated protein 1Add BLAST1530

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Modified residuei277PhosphotyrosineBy similarity1
Modified residuei289PhosphoserineBy similarity1
Modified residuei503N6-succinyllysineBy similarity1
Modified residuei915PhosphoserineBy similarity1
Modified residuei930PhosphoserineBy similarity1
Glycosylationi1005N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8HXQ5.
PRIDEiQ8HXQ5.

Expressioni

Tissue specificityi

Expressed in heart, spleen, lung, kidney, skeletal muscle, mammary gland and weaker in brain and liver.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028094.

Structurei

3D structure databases

ProteinModelPortaliQ8HXQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini325 – 608ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini644 – 868ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini974 – 1255ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1292 – 1526ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi915 – 921Poly-Ser7

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ8HXQ5.
KOiK05665.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HXQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALRDFCSVD GSDLFWEWNV TWNTSNPDFT KCFQNTVLVW VPCSYLWVCF
60 70 80 90 100
PFYFLYLSHH DRGYIQMTHL NKAKTALGFL LWIVCWADLF YSFWERSMGK
110 120 130 140 150
LLAPVFLVSP TLLGITMLLA TFLIQIERRR GVQSSGIMLT FWLIALLCAL
160 170 180 190 200
AILRSKIMTA LKEDARVDVF RDVTFYIYFS LVLIQLVLSC FSDRSPLFSE
210 220 230 240 250
TINDPNPCPE SSASFLSRIT FWWITGMMVQ GYRQPLESTD LWSLNKEDTS
260 270 280 290 300
EQVVPVLVKN WKKECAKSRK QPVKIVYSSK DPAKPKGSSK VDVNEEAEAL
310 320 330 340 350
IVKCPQKERD PSLFKVLYKT FGPYFLMSFL FKAVHDLMMF AGPEILKLLI
360 370 380 390 400
NFVNDKKAPE WQGYFYTALL FISACLQTLV LHQYFHICFV SGMRIKTAVI
410 420 430 440 450
GAVYRKALVI TNAARKSSTV GEIVNLMSVD AQRFMDLATY INMIWSAPLQ
460 470 480 490 500
VILALYLLWL NLGPSVLAGV AVMVLMVPLN AVMAMKTKTY QVAHMKSKDN
510 520 530 540 550
RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK KSAYLAAVGT
560 570 580 590 600
FTWVCTPFLV ALSTFAVYVT VDENNILDAQ KAFVSLALFN ILRFPLNILP
610 620 630 640 650
MVISSIVQAS VSLKRLRVFL SHEDLDPDSI QRRPIKDAGA TNSITVKNAT
660 670 680 690 700
FTWARNDPPT LHGITFSVPE GSLVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVTVKGSVAY VPQQAWIQNI SLRENILFGR QLQERYYKAV VEACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYCDSDVYL LDDPLSAVDA
810 820 830 840 850
HVGKHIFENV IGPKGLLKNK TRLLVTHAIS YLPQMDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLARDG AFAEFLRTYA SAEQEQGQPE DGLAGVGGPG KEVKQMENGM
910 920 930 940 950
LVTDTAGKQM QRQLSSSSSY SRDVSQHHTS TAELRKPGPT EETWKLVEAD
960 970 980 990 1000
KAQTGQVKLS VYWDYMKAIG LFISFLSIFL FLCNHVASLV SNYWLSLWTD
1010 1020 1030 1040 1050
DPIVNGTQEH TQVRLSVYGA LGISQGITVF GYSMAVSIGG IFASRRLHLD
1060 1070 1080 1090 1100
LLHNVLRSPI SFFERTPSGN LVNRFSKELD TVDSMIPQVI KMFMGSLFNV
1110 1120 1130 1140 1150
IGACIIILLA TPMAAVIIPP LGLIYFFVQR FYVASSRQLK RLESVSRSPV
1160 1170 1180 1190 1200
YSHFNETLLG VSVIRAFEEQ ERFIRQSDLK VDENQKAYYP SIVANRWLAV
1210 1220 1230 1240 1250
RLECVGNCIV LFASLFAVIS RHSLSAGLVG LSVSYSLQVT TYLNWLVRMS
1260 1270 1280 1290 1300
SEMETNIVAV ERLKEYSETE KEAPWQIQDM APPKDWPQVG RVEFRDYGLR
1310 1320 1330 1340 1350
YREDLDLVLK HINVTIDGGE KVGIVGRTGA GKSSLTLGLF RIKESAEGEI
1360 1370 1380 1390 1400
IIDDINIAKI GLHDLRFKIT IIPQDPVLFS GSLRMNLDPF SQYSDEEVWT
1410 1420 1430 1440 1450
SLELAHLKGF VSALPDKLNH ECAEGGENLS VGQRQLVCLA RALLRKTKIL
1460 1470 1480 1490 1500
VLDEATAAVD LETDDLIQST IRTQFDDCTV LTIAHRLNTI MDYTRVIVLD
1510 1520 1530
KGEIQEWGSP SDLLQQRGLF YSMAKDSGLV
Length:1,530
Mass (Da):171,666
Last modified:March 1, 2003 - v1
Checksum:iAAE4F92ED7832703
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082124 mRNA. Translation: BAC15550.1.
RefSeqiNP_776648.1. NM_174223.1.
UniGeneiBt.88646.

Genome annotation databases

GeneIDi281588.
KEGGibta:281588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB082124 mRNA. Translation: BAC15550.1.
RefSeqiNP_776648.1. NM_174223.1.
UniGeneiBt.88646.

3D structure databases

ProteinModelPortaliQ8HXQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028094.

Proteomic databases

PaxDbiQ8HXQ5.
PRIDEiQ8HXQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281588.
KEGGibta:281588.

Organism-specific databases

CTDi4363.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ8HXQ5.
KOiK05665.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP1_BOVIN
AccessioniPrimary (citable) accession number: Q8HXQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.