Q8HXK9 (ASC_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Apoptosis-associated speck-like protein containing a CARD

Alternative name(s):
PYD and CARD domain-containing protein

Gene names

Name:	PYCARD
Synonyms:	ASC

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases By similarity.
Subunit structure	Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1 By similarity.
Subcellular location	Cytoplasm By similarity. Note: Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures By similarity.
Domain	Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain By similarity.
Post-translational modification	Phosphorylated By similarity.
Sequence similarities	Contains 1 CARD domain. Contains 1 DAPIN domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Disease	Tumor suppressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from sequence or structural similarity. Source: HGNC positive regulation of interleukin-1 beta secretion Inferred from sequence or structural similarity. Source: HGNC proteolysis Inferred from electronic annotation. Source: InterPro regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: HGNC
Molecular function	Pyrin domain binding Inferred from sequence or structural similarity. Source: HGNC cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro protein homodimerization activity Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 195	195	Apoptosis-associated speck-like protein containing a CARD		PRO_0000245585
Regions
	Domain	1 – 91	91	DAPIN
	Domain	107 – 195	89	CARD

Sequences

	Sequence		Length	Mass (Da)
	Q8HXK9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 7C9D4BD8DBA9A9E8	FASTA	195	21,917
	10 20 30 40 50 60 MGCTRDAILD ALENLTADEL KKFKMKLLSV PLREGYGRIP RGTLLPLDAV DLTDKLVSYY 70 80 90 100 110 120 LEAYGAELTA LVLRDMGMQE VAEQLQETMS KGPRNVLAEV RDPLQKTAKP GLHFVDQHRA 130 140 150 160 170 180 ALIARVTVVD GVLDALYGKV LTEEQYQAVR AERTSSDKMR KLFSFSPAWN MTCKDLLLQA 190 LRDTQPYLVD DLEQS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Masumoto J., Sagara J., Taniguchi S. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB050006 mRNA. Translation: BAC43753.1. BC102385 mRNA. Translation: AAI02386.1.
IPI	IPI00704268.
RefSeq	NP_777155.1. NM_174730.2.
UniGene	Bt.11586.
3D structure databases
ProteinModelPortal	Q8HXK9.
SMR	Q8HXK9. Positions 1-86.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8HXK9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	282846.
KEGG	bta:282846.
Organism-specific databases
CTD	29108.
Phylogenomic databases
eggNOG	maNOG18554.
GeneTree	ENSGT00440000033973.
HOVERGEN	HBG018739.
InParanoid	Q8HXK9.
OrthoDB	EOG4JHCHC.
Family and domain databases
InterPro	IPR001315. CARD. IPR011029. DEATH-like. IPR002398. Pept_C14_p45. IPR004020. Pyrin. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 2 hits.
KO	K12799.
PANTHER	PTHR10454. Pept_C14_p45. 1 hit.
Pfam	PF00619. CARD. 1 hit. PF02758. PAAD_DAPIN. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 2 hits.
PROSITE	PS50209. CARD. 1 hit. PS50824. DAPIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASC_BOVIN

Accession

Primary (citable) accession number: Q8HXK9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program