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Q8HXE4

- GDPP1_MACFA

UniProt

Q8HXE4 - GDPP1_MACFA

Protein

GDP-D-glucose phosphorylase 1

Gene

GDPGP1

Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.By similarity

    Catalytic activityi

    GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei218 – 2181Tele-GMP-histidine intermediateBy similarity

    GO - Molecular functioni

    1. GDP-D-glucose phosphorylase activity Source: UniProtKB
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    3. hydrolase activity Source: UniProtKB-KW
    4. nucleotide binding Source: UniProtKB-KW
    5. nucleotidyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glucose metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor, Hydrolase, Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDP-D-glucose phosphorylase 1 (EC:2.7.7.78)
    Gene namesi
    Name:GDPGP1
    ORF Names:QflA-20034
    OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
    Taxonomic identifieri9541 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385GDP-D-glucose phosphorylase 1PRO_0000336751Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HXE4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDPGP1 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106673.

    Family and domain databases

    InterProiIPR026506. GDPGP.
    [Graphical view]
    PANTHERiPTHR20884. PTHR20884. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8HXE4-1 [UniParc]FASTAAdd to Basket

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    MALPHDSNET SYLLPPNNED WDRQAIPDFV YGQKDLMAEG IQWPRNAPGV    50
    LEALPQSPFD AALCSAWKQR VELGLFRYRL RELQTQILPG VVGFVAQLNV 100
    ERGVQRRRPQ TIKSVRQAFD PEQFNFNKIQ PGEVLYRLHR EPDLPGTLLQ 150
    EDILVVINVS PLEWGHVLLV PEPARGLPQR LLPGALRAGI EAVLLSLHPG 200
    FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP GGHLHLLQGL 250
    PAPGFLFYTR GPGLDLESLI CRVCRATDYL TDHEIAHNLF VTRGAPPGKT 300
    SPSSALTGVR VILWARKSCF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL 350
    TEAAAVALIQ DCRLPPSQAE EVQAALVALM SQKEQ 385
    Length:385
    Mass (Da):42,444
    Last modified:March 1, 2003 - v1
    Checksum:iA83701F59EAA6898
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093646 mRNA. Translation: BAC21620.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093646 mRNA. Translation: BAC21620.1 .

    3D structure databases

    ProteinModelPortali Q8HXE4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106673.

    Family and domain databases

    InterProi IPR026506. GDPGP.
    [Graphical view ]
    PANTHERi PTHR20884. PTHR20884. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
      International consortium for macaque cDNA sequencing and analysis
      Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Frontal cortex.

    Entry informationi

    Entry nameiGDPP1_MACFA
    AccessioniPrimary (citable) accession number: Q8HXE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    The orthologs in A.thaliana catalyze the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3