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Q8HXE4

- GDPP1_MACFA

UniProt

Q8HXE4 - GDPP1_MACFA

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Protein

GDP-D-glucose phosphorylase 1

Gene
GDPGP1, QflA-20034
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells By similarity.

Catalytic activityi

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181Tele-GMP-histidine intermediate By similarity

GO - Molecular functioni

  1. GDP-D-glucose phosphorylase activity Source: UniProtKB
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
  3. hydrolase activity Source: UniProtKB-KW
  4. nucleotide binding Source: UniProtKB-KW
  5. nucleotidyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Hydrolase, Nucleotidyltransferase, Transferase

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GDP-D-glucose phosphorylase 1 (EC:2.7.7.78)
Gene namesi
Name:GDPGP1
ORF Names:QflA-20034
OrganismiMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifieri9541 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385GDP-D-glucose phosphorylase 1PRO_0000336751Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8HXE4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GDPGP1 family.

Phylogenomic databases

HOVERGENiHBG106673.

Family and domain databases

InterProiIPR026506. GDPGP.
[Graphical view]
PANTHERiPTHR20884. PTHR20884. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8HXE4-1 [UniParc]FASTAAdd to Basket

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MALPHDSNET SYLLPPNNED WDRQAIPDFV YGQKDLMAEG IQWPRNAPGV    50
LEALPQSPFD AALCSAWKQR VELGLFRYRL RELQTQILPG VVGFVAQLNV 100
ERGVQRRRPQ TIKSVRQAFD PEQFNFNKIQ PGEVLYRLHR EPDLPGTLLQ 150
EDILVVINVS PLEWGHVLLV PEPARGLPQR LLPGALRAGI EAVLLSLHPG 200
FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP GGHLHLLQGL 250
PAPGFLFYTR GPGLDLESLI CRVCRATDYL TDHEIAHNLF VTRGAPPGKT 300
SPSSALTGVR VILWARKSCF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL 350
TEAAAVALIQ DCRLPPSQAE EVQAALVALM SQKEQ 385
Length:385
Mass (Da):42,444
Last modified:March 1, 2003 - v1
Checksum:iA83701F59EAA6898
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093646 mRNA. Translation: BAC21620.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093646 mRNA. Translation: BAC21620.1 .

3D structure databases

ProteinModelPortali Q8HXE4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106673.

Family and domain databases

InterProi IPR026506. GDPGP.
[Graphical view ]
PANTHERi PTHR20884. PTHR20884. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
    International consortium for macaque cDNA sequencing and analysis
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Frontal cortex.

Entry informationi

Entry nameiGDPP1_MACFA
AccessioniPrimary (citable) accession number: Q8HXE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

The orthologs in A.thaliana catalyze the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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