Q8HXE4 (GDPP1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GDP-D-glucose phosphorylase 1
EC=2.7.7.78

Gene names

Name:	GDPGP1
ORF Names:	QflA-20034

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Taxonomic identifier

9541 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells By similarity.
Catalytic activity	GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GDPGP1 family.
Caution	The orthologs in A.thaliana catalyze the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Nucleotide-binding
Molecular function	Guanine-nucleotide releasing factor Hydrolase Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological_process	glucose metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	GDP-D-glucose phosphorylase activity Inferred from sequence or structural similarity. Source: UniProtKB guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: UniProtKB-KW hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotidyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	GDP-D-glucose phosphorylase 1		PRO_0000336751
Sites
	Active site	218	1	Tele-GMP-histidine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8HXE4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A83701F59EAA6898	FASTA	385	42,444
	10 20 30 40 50 60 MALPHDSNET SYLLPPNNED WDRQAIPDFV YGQKDLMAEG IQWPRNAPGV LEALPQSPFD 70 80 90 100 110 120 AALCSAWKQR VELGLFRYRL RELQTQILPG VVGFVAQLNV ERGVQRRRPQ TIKSVRQAFD 130 140 150 160 170 180 PEQFNFNKIQ PGEVLYRLHR EPDLPGTLLQ EDILVVINVS PLEWGHVLLV PEPARGLPQR 190 200 210 220 230 240 LLPGALRAGI EAVLLSLHPG FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP 250 260 270 280 290 300 GGHLHLLQGL PAPGFLFYTR GPGLDLESLI CRVCRATDYL TDHEIAHNLF VTRGAPPGKT 310 320 330 340 350 360 SPSSALTGVR VILWARKSCF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL TEAAAVALIQ 370 380 DCRLPPSQAE EVQAALVALM SQKEQ

References

[1]	"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications." International consortium for macaque cDNA sequencing and analysis Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Frontal cortex.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB093646 mRNA. Translation: BAC21620.1.
3D structure databases
ProteinModelPortal	Q8HXE4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG106673.
Family and domain databases
InterPro	IPR026506. GDPGP1. [Graphical view]
PANTHER	PTHR20884:SF4. PTHR20884:SF4. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GDPP1_MACFA

Accession

Primary (citable) accession number: Q8HXE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 1, 2003
Last modified:	October 3, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program