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Q8HXE4 (GDPP1_MACFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GDP-D-glucose phosphorylase 1

EC=2.7.7.78
Gene names
Name:GDPGP1
ORF Names:QflA-20034
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Taxonomic identifier9541 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells By similarity.

Catalytic activity

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the GDPGP1 family.

Caution

The orthologs in A.thaliana catalyze the first reaction of the Smirnoff-Wheeler pathway, the major route to ascorbate biosynthesis in plants.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385GDP-D-glucose phosphorylase 1
PRO_0000336751

Sites

Active site2181Tele-GMP-histidine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8HXE4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A83701F59EAA6898

FASTA38542,444
        10         20         30         40         50         60 
MALPHDSNET SYLLPPNNED WDRQAIPDFV YGQKDLMAEG IQWPRNAPGV LEALPQSPFD 

        70         80         90        100        110        120 
AALCSAWKQR VELGLFRYRL RELQTQILPG VVGFVAQLNV ERGVQRRRPQ TIKSVRQAFD 

       130        140        150        160        170        180 
PEQFNFNKIQ PGEVLYRLHR EPDLPGTLLQ EDILVVINVS PLEWGHVLLV PEPARGLPQR 

       190        200        210        220        230        240 
LLPGALRAGI EAVLLSLHPG FRVGFNSLGG LASVNHLHLH GYYLAHRLPV EQAPSEPLDP 

       250        260        270        280        290        300 
GGHLHLLQGL PAPGFLFYTR GPGLDLESLI CRVCRATDYL TDHEIAHNLF VTRGAPPGKT 

       310        320        330        340        350        360 
SPSSALTGVR VILWARKSCF GIKDGEAFNV ALCELAGHLP VKTSQDFSSL TEAAAVALIQ 

       370        380 
DCRLPPSQAE EVQAALVALM SQKEQ 

« Hide

References

[1]"DNA sequences of macaque genes expressed in brain or testis and its evolutionary implications."
International consortium for macaque cDNA sequencing and analysis
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Frontal cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB093646 mRNA. Translation: BAC21620.1.

3D structure databases

ProteinModelPortalQ8HXE4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106673.

Family and domain databases

InterProIPR026506. GDPGP1.
[Graphical view]
PANTHERPTHR20884:SF4. PTHR20884:SF4. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGDPP1_MACFA
AccessionPrimary (citable) accession number: Q8HXE4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families