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Protein

Thiopurine S-methyltransferase

Gene

TPMT

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40SubstrateBy similarity1
Binding sitei69S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei90S-adenosyl-L-methionineBy similarity1
Binding sitei152S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiR-CFA-156581 Methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Thiopurine S-methyltransferase (EC:2.1.1.67)
Alternative name(s):
Thiopurine methyltransferase
Gene namesi
Name:TPMT
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 35

Organism-specific databases

VGNCiVGNC:47745 TPMT

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002200971 – 245Thiopurine S-methyltransferaseAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8HX86
PRIDEiQ8HX86

Expressioni

Gene expression databases

BgeeiENSCAFG00000010160

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014924

Structurei

3D structure databases

ProteinModelPortaliQ8HX86
SMRiQ8HX86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 40S-adenosyl-L-methionine bindingBy similarityAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGTR Eukaryota
ENOG4111GNF LUCA
GeneTreeiENSGT00390000016823
HOGENOMiHOG000276919
HOVERGENiHBG003037
InParanoidiQ8HX86
KOiK00569
OMAiMKWFADR
OrthoDBiEOG091G0VS2
TreeFamiTF328951

Family and domain databases

HAMAPiMF_00812 Thiopur_methtran, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025835 Thiopurine_S-MeTrfase
IPR008854 TPMT
PANTHERiPTHR10259 PTHR10259, 1 hit
PfamiView protein in Pfam
PF05724 TPMT, 1 hit
PIRSFiPIRSF023956 Thiopurine_S-methyltransferase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51585 SAM_MT_TPMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8HX86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKTRTFLDV KEYPDTEVQK NRVLTLEEWQ EKWVSRRIGF HQEQGHKLLK
60 70 80 90 100
KHLDTFLKGE NGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIREFF
110 120 130 140 150
AEQNLSYTEE PIVEIPGGKI FKSSSGNISL YCCSLFDLPR ANIGKFDRIW
160 170 180 190 200
DRGALVAINP GDRERYADIM LSLTRKGFHY LLAVLCYDPT KHAGPPFYVP
210 220 230 240
EAEIKKLFGS ICNIHCLEKV DVFEEQHKSW GIDYIIEKLY LFTEK
Length:245
Mass (Da):28,428
Last modified:March 1, 2003 - v1
Checksum:iFF248133D3F8EF5A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti97R → G1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY057077 mRNA Translation: AAL18009.1
AY057087
, AY057080, AY057081, AY057082, AY057083, AY057084, AY057085, AY057086 Genomic DNA Translation: AAL18006.1
RefSeqiNP_001003015.1, NM_001003015.1
XP_005640012.1, XM_005639955.2
XP_005640013.1, XM_005639956.2
XP_013965954.1, XM_014110479.1
UniGeneiCfa.33

Genome annotation databases

EnsembliENSCAFT00000016138; ENSCAFP00000014924; ENSCAFG00000010160
ENSCAFT00000016139; ENSCAFP00000014925; ENSCAFG00000010160
GeneIDi403536
KEGGicfa:403536

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTPMT_CANLF
AccessioniPrimary (citable) accession number: Q8HX86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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