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Q8HEC3

- COX2_CAEBR

UniProt

Q8HEC3 - COX2_CAEBR

Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi164 – 1641Copper ACurated
    Metal bindingi199 – 1991Copper ACurated
    Metal bindingi203 – 2031Copper ACurated
    Metal bindingi207 – 2071Copper ACurated

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:cox-2
    Synonyms:coII
    Encoded oniMitochondrionImported
    OrganismiCaenorhabditis briggsaeImported
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Mitochondrion

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Cytochrome c oxidase subunit 2PRO_0000183525Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ8HEC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini52 – 6413Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini86 – 231146Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei65 – 8521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02261.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8HEC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNFFQGYNL LFQHSLFASY MDWFHAFNCS LLLGVLVFVT LLFGYLIFST    50
    FYFKSKKIEY QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV 100
    KVTGHQWYWS YEYSDIPGLE FDSYMKSLDQ LNLGEPRLLE VDNRCVIPCD 150
    TNIRFCITSA DVIHAWALNS LSVKLDAMSG ILSTFSYSFP MVGVFYGQCS 200
    EICGANHSFM PIALEVTLLD NFKSWCFGTM E 231
    Length:231
    Mass (Da):26,590
    Last modified:March 1, 2003 - v1
    Checksum:i646AA84FD14D11E0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161L → M in strain: PB826. 3 Publications
    Natural varianti21 – 211M → T in strain: ED3092 and ED3101. 1 Publication
    Natural varianti61 – 611Q → L in strain: BW287. 1 Publication
    Natural varianti141 – 1411V → A in strain: JU403. 1 Publication
    Natural varianti142 – 1421D → H in strain: EG4207A. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY171103 Genomic DNA. Translation: AAO13510.1.
    EU407781 Genomic DNA. Translation: ACB06109.1.
    EU407782 Genomic DNA. Translation: ACB06121.1.
    EU407783 Genomic DNA. Translation: ACB06133.1.
    EU407784 Genomic DNA. Translation: ACB06145.1.
    EU407785 Genomic DNA. Translation: ACB06157.1.
    EU407786 Genomic DNA. Translation: ACB06169.1.
    EU407787 Genomic DNA. Translation: ACB06181.1.
    EU407788 Genomic DNA. Translation: ACB06193.1.
    EU407789 Genomic DNA. Translation: ACB06205.1.
    EU407790 Genomic DNA. Translation: ACB06217.1.
    EU407791 Genomic DNA. Translation: ACB06229.1.
    EU407792 Genomic DNA. Translation: ACB06241.1.
    EU407793 Genomic DNA. Translation: ACB06253.1.
    EU407794 Genomic DNA. Translation: ACB06265.1.
    EU407795 Genomic DNA. Translation: ACB06277.1.
    EU407796 Genomic DNA. Translation: ACB06289.1.
    EU407797 Genomic DNA. Translation: ACB06301.1.
    EU407798 Genomic DNA. Translation: ACB06313.1.
    EU407799 Genomic DNA. Translation: ACB06325.1.
    EU407800 Genomic DNA. Translation: ACB06337.1.
    EU407801 Genomic DNA. Translation: ACB06349.1.
    EU407802 Genomic DNA. Translation: ACB06361.1.
    EU407803 Genomic DNA. Translation: ACB06373.1.
    AC186293 Genomic DNA. No translation available.
    AF491452 Genomic DNA. Translation: AAM09746.1.
    AF491453 Genomic DNA. Translation: AAM09747.1.
    AF491454 Genomic DNA. Translation: AAM09748.1.
    AF491455 Genomic DNA. Translation: AAM09749.1.
    AF491456 Genomic DNA. Translation: AAM09750.1.
    AF491457 Genomic DNA. Translation: AAM09751.1.
    EU254734 Genomic DNA. Translation: ABX84167.1.
    EU254735 Genomic DNA. Translation: ABX84168.1.
    EU254736 Genomic DNA. Translation: ABX84169.1.
    EU254737 Genomic DNA. Translation: ABX84170.1.
    EU254738 Genomic DNA. Translation: ABX84171.1.
    EU254739 Genomic DNA. Translation: ABX84172.1.
    EU254740 Genomic DNA. Translation: ABX84173.1.
    EU254741 Genomic DNA. Translation: ABX84174.1.
    EU254742 Genomic DNA. Translation: ABX84175.1.
    EU254743 Genomic DNA. Translation: ABX84176.1.
    RefSeqiYP_001504332.1. NC_009885.1.

    Genome annotation databases

    GeneIDi5666631.
    KEGGicbr:COX2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY171103 Genomic DNA. Translation: AAO13510.1 .
    EU407781 Genomic DNA. Translation: ACB06109.1 .
    EU407782 Genomic DNA. Translation: ACB06121.1 .
    EU407783 Genomic DNA. Translation: ACB06133.1 .
    EU407784 Genomic DNA. Translation: ACB06145.1 .
    EU407785 Genomic DNA. Translation: ACB06157.1 .
    EU407786 Genomic DNA. Translation: ACB06169.1 .
    EU407787 Genomic DNA. Translation: ACB06181.1 .
    EU407788 Genomic DNA. Translation: ACB06193.1 .
    EU407789 Genomic DNA. Translation: ACB06205.1 .
    EU407790 Genomic DNA. Translation: ACB06217.1 .
    EU407791 Genomic DNA. Translation: ACB06229.1 .
    EU407792 Genomic DNA. Translation: ACB06241.1 .
    EU407793 Genomic DNA. Translation: ACB06253.1 .
    EU407794 Genomic DNA. Translation: ACB06265.1 .
    EU407795 Genomic DNA. Translation: ACB06277.1 .
    EU407796 Genomic DNA. Translation: ACB06289.1 .
    EU407797 Genomic DNA. Translation: ACB06301.1 .
    EU407798 Genomic DNA. Translation: ACB06313.1 .
    EU407799 Genomic DNA. Translation: ACB06325.1 .
    EU407800 Genomic DNA. Translation: ACB06337.1 .
    EU407801 Genomic DNA. Translation: ACB06349.1 .
    EU407802 Genomic DNA. Translation: ACB06361.1 .
    EU407803 Genomic DNA. Translation: ACB06373.1 .
    AC186293 Genomic DNA. No translation available.
    AF491452 Genomic DNA. Translation: AAM09746.1 .
    AF491453 Genomic DNA. Translation: AAM09747.1 .
    AF491454 Genomic DNA. Translation: AAM09748.1 .
    AF491455 Genomic DNA. Translation: AAM09749.1 .
    AF491456 Genomic DNA. Translation: AAM09750.1 .
    AF491457 Genomic DNA. Translation: AAM09751.1 .
    EU254734 Genomic DNA. Translation: ABX84167.1 .
    EU254735 Genomic DNA. Translation: ABX84168.1 .
    EU254736 Genomic DNA. Translation: ABX84169.1 .
    EU254737 Genomic DNA. Translation: ABX84170.1 .
    EU254738 Genomic DNA. Translation: ABX84171.1 .
    EU254739 Genomic DNA. Translation: ABX84172.1 .
    EU254740 Genomic DNA. Translation: ABX84173.1 .
    EU254741 Genomic DNA. Translation: ABX84174.1 .
    EU254742 Genomic DNA. Translation: ABX84175.1 .
    EU254743 Genomic DNA. Translation: ABX84176.1 .
    RefSeqi YP_001504332.1. NC_009885.1.

    3D structure databases

    ProteinModelPortali Q8HEC3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5666631.
    KEGGi cbr:COX2.

    Organism-specific databases

    CTDi 4513.

    Phylogenomic databases

    KOi K02261.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 1 hit.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    PF02790. COX2_TM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 1 hit.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    PS50999. COX2_TM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
      Denver D.R., Morris K., Thomas W.K.
      Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: PB800.
    2. "Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution."
      Howe D.K., Denver D.R.
      BMC Evol. Biol. 8:62-62(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-16; THR-21; LEU-61; ALA-141 AND HIS-142.
      Strain: BW287, ED3032, ED3033, ED3034, ED3035, ED3036, ED3037, ED3083, ED3092, ED3101, EG4181, EG4207A, HK104, HK105, JU403, JU439, JU516, JU725, JU726, JU793, PB800, PB826 and VT847.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.
    4. "Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
      Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
      Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-231, VARIANT MET-16.
      Strain: AF16, HK104, HK105, PB800, PB826 and VT847.
    5. "An entomopathogenic Caenorhabditis."
      Thomas W.K., Abebe E.B., Jumba M., Gray V., Bonner K., Morris K.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-230, VARIANT MET-16.
      Strain: AF16, DR1690, HK104, HK105, JU725, JU726, KT0001, PB800, PB826 and VT847.

    Entry informationi

    Entry nameiCOX2_CAEBR
    AccessioniPrimary (citable) accession number: Q8HEC3
    Secondary accession number(s): A9YMI3
    , A9YMI8, A9YMI9, B1PE42, B1PE54, B1PED8, B1PEH4, B1PEL0, Q8SEN0, Q8SFX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3