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Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds a copper A center.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi164Copper ACurated1
Metal bindingi199Copper ACurated1
Metal bindingi203Copper ACurated1
Metal bindingi207Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
Encoded oniMitochondrionImported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30Mitochondrial intermembraneSequence analysisAdd BLAST30
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Topological domaini52 – 64Mitochondrial matrixSequence analysisAdd BLAST13
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21
Topological domaini86 – 231Mitochondrial intermembraneSequence analysisAdd BLAST146

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001835251 – 231Cytochrome c oxidase subunit 2Add BLAST231

Structurei

3D structure databases

ProteinModelPortaliQ8HEC3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ8HEC3
KOiK02261

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8HEC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFFQGYNL LFQHSLFASY MDWFHAFNCS LLLGVLVFVT LLFGYLIFST
60 70 80 90 100
FYFKSKKIEY QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV
110 120 130 140 150
KVTGHQWYWS YEYSDIPGLE FDSYMKSLDQ LNLGEPRLLE VDNRCVIPCD
160 170 180 190 200
TNIRFCITSA DVIHAWALNS LSVKLDAMSG ILSTFSYSFP MVGVFYGQCS
210 220 230
EICGANHSFM PIALEVTLLD NFKSWCFGTM E
Length:231
Mass (Da):26,590
Last modified:March 1, 2003 - v1
Checksum:i646AA84FD14D11E0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti16L → M in strain: PB826. 3 Publications1
Natural varianti21M → T in strain: ED3092 and ED3101. 1 Publication1
Natural varianti61Q → L in strain: BW287. 1 Publication1
Natural varianti141V → A in strain: JU403. 1 Publication1
Natural varianti142D → H in strain: EG4207A. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171103 Genomic DNA Translation: AAO13510.1
EU407781 Genomic DNA Translation: ACB06109.1
EU407782 Genomic DNA Translation: ACB06121.1
EU407783 Genomic DNA Translation: ACB06133.1
EU407784 Genomic DNA Translation: ACB06145.1
EU407785 Genomic DNA Translation: ACB06157.1
EU407786 Genomic DNA Translation: ACB06169.1
EU407787 Genomic DNA Translation: ACB06181.1
EU407788 Genomic DNA Translation: ACB06193.1
EU407789 Genomic DNA Translation: ACB06205.1
EU407790 Genomic DNA Translation: ACB06217.1
EU407791 Genomic DNA Translation: ACB06229.1
EU407792 Genomic DNA Translation: ACB06241.1
EU407793 Genomic DNA Translation: ACB06253.1
EU407794 Genomic DNA Translation: ACB06265.1
EU407795 Genomic DNA Translation: ACB06277.1
EU407796 Genomic DNA Translation: ACB06289.1
EU407797 Genomic DNA Translation: ACB06301.1
EU407798 Genomic DNA Translation: ACB06313.1
EU407799 Genomic DNA Translation: ACB06325.1
EU407800 Genomic DNA Translation: ACB06337.1
EU407801 Genomic DNA Translation: ACB06349.1
EU407802 Genomic DNA Translation: ACB06361.1
EU407803 Genomic DNA Translation: ACB06373.1
AC186293 Genomic DNA No translation available.
AF491452 Genomic DNA Translation: AAM09746.1
AF491453 Genomic DNA Translation: AAM09747.1
AF491454 Genomic DNA Translation: AAM09748.1
AF491455 Genomic DNA Translation: AAM09749.1
AF491456 Genomic DNA Translation: AAM09750.1
AF491457 Genomic DNA Translation: AAM09751.1
EU254734 Genomic DNA Translation: ABX84167.1
EU254735 Genomic DNA Translation: ABX84168.1
EU254736 Genomic DNA Translation: ABX84169.1
EU254737 Genomic DNA Translation: ABX84170.1
EU254738 Genomic DNA Translation: ABX84171.1
EU254739 Genomic DNA Translation: ABX84172.1
EU254740 Genomic DNA Translation: ABX84173.1
EU254741 Genomic DNA Translation: ABX84174.1
EU254742 Genomic DNA Translation: ABX84175.1
EU254743 Genomic DNA Translation: ABX84176.1
RefSeqiYP_001504332.1, NC_009885.1

Genome annotation databases

GeneIDi5666631
KEGGicbr:COX2

Similar proteinsi

Entry informationi

Entry nameiCOX2_CAEBR
AccessioniPrimary (citable) accession number: Q8HEC3
Secondary accession number(s): A9YMI3
, A9YMI8, A9YMI9, B1PE42, B1PE54, B1PED8, B1PEH4, B1PEL0, Q8SEN0, Q8SFX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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