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Q8HEC3 (COX2_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:cox-2
Synonyms:coII
Encoded onMitochondrion
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. UniProtKB P24894

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A. UniProtKB P24894

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Cytochrome c oxidase subunit 2
PRO_0000183525

Regions

Topological domain1 – 3030Mitochondrial intermembrane Potential
Transmembrane31 – 5121Helical; Potential
Topological domain52 – 6413Mitochondrial matrix Potential
Transmembrane65 – 8521Helical; Potential
Topological domain86 – 231146Mitochondrial intermembrane Potential

Sites

Metal binding1641Copper A Probable UniProtKB P24894
Metal binding1991Copper A Probable UniProtKB P24894
Metal binding2031Copper A Probable UniProtKB P24894
Metal binding2071Copper A Probable UniProtKB P24894

Natural variations

Natural variant161L → M in strain: PB826. Ref.2 Ref.4 Ref.5
Natural variant211M → T in strain: ED3092 and ED3101. Ref.2
Natural variant611Q → L in strain: BW287. Ref.2
Natural variant1411V → A in strain: JU403. Ref.2
Natural variant1421D → H in strain: EG4207A. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8HEC3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 646AA84FD14D11E0

FASTA23126,590
        10         20         30         40         50         60 
MNNFFQGYNL LFQHSLFASY MDWFHAFNCS LLLGVLVFVT LLFGYLIFST FYFKSKKIEY 

        70         80         90        100        110        120 
QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV KVTGHQWYWS YEYSDIPGLE 

       130        140        150        160        170        180 
FDSYMKSLDQ LNLGEPRLLE VDNRCVIPCD TNIRFCITSA DVIHAWALNS LSVKLDAMSG 

       190        200        210        220        230 
ILSTFSYSFP MVGVFYGQCS EICGANHSFM PIALEVTLLD NFKSWCFGTM E 

« Hide

References

« Hide 'large scale' references
[1]"Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
Denver D.R., Morris K., Thomas W.K.
Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: PB800.
[2]"Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution."
Howe D.K., Denver D.R.
BMC Evol. Biol. 8:62-62(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-16; THR-21; LEU-61; ALA-141 AND HIS-142.
Strain: BW287, ED3032, ED3033, ED3034, ED3035, ED3036, ED3037, ED3083, ED3092, ED3101, EG4181, EG4207A, HK104, HK105, JU403, JU439, JU516, JU725, JU726, JU793, PB800, PB826 and VT847.
[3]"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics."
Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. expand/collapse author list , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H.
PLoS Biol. 1:166-192(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AF16.
[4]"Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-231, VARIANT MET-16.
Strain: AF16, HK104, HK105, PB800, PB826 and VT847.
[5]"An entomopathogenic Caenorhabditis."
Thomas W.K., Abebe E.B., Jumba M., Gray V., Bonner K., Morris K.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-230, VARIANT MET-16.
Strain: AF16, DR1690, HK104, HK105, JU725, JU726, KT0001, PB800, PB826 and VT847.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY171103 Genomic DNA. Translation: AAO13510.1.
EU407781 Genomic DNA. Translation: ACB06109.1.
EU407782 Genomic DNA. Translation: ACB06121.1.
EU407783 Genomic DNA. Translation: ACB06133.1.
EU407784 Genomic DNA. Translation: ACB06145.1.
EU407785 Genomic DNA. Translation: ACB06157.1.
EU407786 Genomic DNA. Translation: ACB06169.1.
EU407787 Genomic DNA. Translation: ACB06181.1.
EU407788 Genomic DNA. Translation: ACB06193.1.
EU407789 Genomic DNA. Translation: ACB06205.1.
EU407790 Genomic DNA. Translation: ACB06217.1.
EU407791 Genomic DNA. Translation: ACB06229.1.
EU407792 Genomic DNA. Translation: ACB06241.1.
EU407793 Genomic DNA. Translation: ACB06253.1.
EU407794 Genomic DNA. Translation: ACB06265.1.
EU407795 Genomic DNA. Translation: ACB06277.1.
EU407796 Genomic DNA. Translation: ACB06289.1.
EU407797 Genomic DNA. Translation: ACB06301.1.
EU407798 Genomic DNA. Translation: ACB06313.1.
EU407799 Genomic DNA. Translation: ACB06325.1.
EU407800 Genomic DNA. Translation: ACB06337.1.
EU407801 Genomic DNA. Translation: ACB06349.1.
EU407802 Genomic DNA. Translation: ACB06361.1.
EU407803 Genomic DNA. Translation: ACB06373.1.
AC186293 Genomic DNA. No translation available.
AF491452 Genomic DNA. Translation: AAM09746.1.
AF491453 Genomic DNA. Translation: AAM09747.1.
AF491454 Genomic DNA. Translation: AAM09748.1.
AF491455 Genomic DNA. Translation: AAM09749.1.
AF491456 Genomic DNA. Translation: AAM09750.1.
AF491457 Genomic DNA. Translation: AAM09751.1.
EU254734 Genomic DNA. Translation: ABX84167.1.
EU254735 Genomic DNA. Translation: ABX84168.1.
EU254736 Genomic DNA. Translation: ABX84169.1.
EU254737 Genomic DNA. Translation: ABX84170.1.
EU254738 Genomic DNA. Translation: ABX84171.1.
EU254739 Genomic DNA. Translation: ABX84172.1.
EU254740 Genomic DNA. Translation: ABX84173.1.
EU254741 Genomic DNA. Translation: ABX84174.1.
EU254742 Genomic DNA. Translation: ABX84175.1.
EU254743 Genomic DNA. Translation: ABX84176.1.
RefSeqYP_001504332.1. NC_009885.1.

3D structure databases

ProteinModelPortalQ8HEC3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5666631.
KEGGcbr:COX2.

Organism-specific databases

CTD4513.

Phylogenomic databases

KOK02261.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_CAEBR
AccessionPrimary (citable) accession number: Q8HEC3
Secondary accession number(s): A9YMI3 expand/collapse secondary AC list , A9YMI8, A9YMI9, B1PE42, B1PE54, B1PED8, B1PEH4, B1PEL0, Q8SEN0, Q8SFX6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families