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Q8HEC3

- COX2_CAEBR

UniProt

Q8HEC3 - COX2_CAEBR

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Protein

Cytochrome c oxidase subunit 2

Gene
cox-2, coII
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641Copper A InferredBy similarity
Metal bindingi199 – 1991Copper A InferredBy similarity
Metal bindingi203 – 2031Copper A InferredBy similarity
Metal bindingi207 – 2071Copper A InferredBy similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
Encoded oniMitochondrion
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Mitochondrial intermembrane Reviewed predictionAdd
BLAST
Transmembranei31 – 5121Helical; Reviewed predictionAdd
BLAST
Topological domaini52 – 6413Mitochondrial matrix Reviewed predictionAdd
BLAST
Transmembranei65 – 8521Helical; Reviewed predictionAdd
BLAST
Topological domaini86 – 231146Mitochondrial intermembrane Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Cytochrome c oxidase subunit 2PRO_0000183525Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8HEC3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02261.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HEC3-1 [UniParc]FASTAAdd to Basket

« Hide

MNNFFQGYNL LFQHSLFASY MDWFHAFNCS LLLGVLVFVT LLFGYLIFST    50
FYFKSKKIEY QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV 100
KVTGHQWYWS YEYSDIPGLE FDSYMKSLDQ LNLGEPRLLE VDNRCVIPCD 150
TNIRFCITSA DVIHAWALNS LSVKLDAMSG ILSTFSYSFP MVGVFYGQCS 200
EICGANHSFM PIALEVTLLD NFKSWCFGTM E 231
Length:231
Mass (Da):26,590
Last modified:March 1, 2003 - v1
Checksum:i646AA84FD14D11E0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161L → M in strain: PB826. 3 Publications
Natural varianti21 – 211M → T in strain: ED3092 and ED3101. 1 Publication
Natural varianti61 – 611Q → L in strain: BW287. 1 Publication
Natural varianti141 – 1411V → A in strain: JU403. 1 Publication
Natural varianti142 – 1421D → H in strain: EG4207A. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY171103 Genomic DNA. Translation: AAO13510.1.
EU407781 Genomic DNA. Translation: ACB06109.1.
EU407782 Genomic DNA. Translation: ACB06121.1.
EU407783 Genomic DNA. Translation: ACB06133.1.
EU407784 Genomic DNA. Translation: ACB06145.1.
EU407785 Genomic DNA. Translation: ACB06157.1.
EU407786 Genomic DNA. Translation: ACB06169.1.
EU407787 Genomic DNA. Translation: ACB06181.1.
EU407788 Genomic DNA. Translation: ACB06193.1.
EU407789 Genomic DNA. Translation: ACB06205.1.
EU407790 Genomic DNA. Translation: ACB06217.1.
EU407791 Genomic DNA. Translation: ACB06229.1.
EU407792 Genomic DNA. Translation: ACB06241.1.
EU407793 Genomic DNA. Translation: ACB06253.1.
EU407794 Genomic DNA. Translation: ACB06265.1.
EU407795 Genomic DNA. Translation: ACB06277.1.
EU407796 Genomic DNA. Translation: ACB06289.1.
EU407797 Genomic DNA. Translation: ACB06301.1.
EU407798 Genomic DNA. Translation: ACB06313.1.
EU407799 Genomic DNA. Translation: ACB06325.1.
EU407800 Genomic DNA. Translation: ACB06337.1.
EU407801 Genomic DNA. Translation: ACB06349.1.
EU407802 Genomic DNA. Translation: ACB06361.1.
EU407803 Genomic DNA. Translation: ACB06373.1.
AC186293 Genomic DNA. No translation available.
AF491452 Genomic DNA. Translation: AAM09746.1.
AF491453 Genomic DNA. Translation: AAM09747.1.
AF491454 Genomic DNA. Translation: AAM09748.1.
AF491455 Genomic DNA. Translation: AAM09749.1.
AF491456 Genomic DNA. Translation: AAM09750.1.
AF491457 Genomic DNA. Translation: AAM09751.1.
EU254734 Genomic DNA. Translation: ABX84167.1.
EU254735 Genomic DNA. Translation: ABX84168.1.
EU254736 Genomic DNA. Translation: ABX84169.1.
EU254737 Genomic DNA. Translation: ABX84170.1.
EU254738 Genomic DNA. Translation: ABX84171.1.
EU254739 Genomic DNA. Translation: ABX84172.1.
EU254740 Genomic DNA. Translation: ABX84173.1.
EU254741 Genomic DNA. Translation: ABX84174.1.
EU254742 Genomic DNA. Translation: ABX84175.1.
EU254743 Genomic DNA. Translation: ABX84176.1.
RefSeqiYP_001504332.1. NC_009885.1.

Genome annotation databases

GeneIDi5666631.
KEGGicbr:COX2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY171103 Genomic DNA. Translation: AAO13510.1 .
EU407781 Genomic DNA. Translation: ACB06109.1 .
EU407782 Genomic DNA. Translation: ACB06121.1 .
EU407783 Genomic DNA. Translation: ACB06133.1 .
EU407784 Genomic DNA. Translation: ACB06145.1 .
EU407785 Genomic DNA. Translation: ACB06157.1 .
EU407786 Genomic DNA. Translation: ACB06169.1 .
EU407787 Genomic DNA. Translation: ACB06181.1 .
EU407788 Genomic DNA. Translation: ACB06193.1 .
EU407789 Genomic DNA. Translation: ACB06205.1 .
EU407790 Genomic DNA. Translation: ACB06217.1 .
EU407791 Genomic DNA. Translation: ACB06229.1 .
EU407792 Genomic DNA. Translation: ACB06241.1 .
EU407793 Genomic DNA. Translation: ACB06253.1 .
EU407794 Genomic DNA. Translation: ACB06265.1 .
EU407795 Genomic DNA. Translation: ACB06277.1 .
EU407796 Genomic DNA. Translation: ACB06289.1 .
EU407797 Genomic DNA. Translation: ACB06301.1 .
EU407798 Genomic DNA. Translation: ACB06313.1 .
EU407799 Genomic DNA. Translation: ACB06325.1 .
EU407800 Genomic DNA. Translation: ACB06337.1 .
EU407801 Genomic DNA. Translation: ACB06349.1 .
EU407802 Genomic DNA. Translation: ACB06361.1 .
EU407803 Genomic DNA. Translation: ACB06373.1 .
AC186293 Genomic DNA. No translation available.
AF491452 Genomic DNA. Translation: AAM09746.1 .
AF491453 Genomic DNA. Translation: AAM09747.1 .
AF491454 Genomic DNA. Translation: AAM09748.1 .
AF491455 Genomic DNA. Translation: AAM09749.1 .
AF491456 Genomic DNA. Translation: AAM09750.1 .
AF491457 Genomic DNA. Translation: AAM09751.1 .
EU254734 Genomic DNA. Translation: ABX84167.1 .
EU254735 Genomic DNA. Translation: ABX84168.1 .
EU254736 Genomic DNA. Translation: ABX84169.1 .
EU254737 Genomic DNA. Translation: ABX84170.1 .
EU254738 Genomic DNA. Translation: ABX84171.1 .
EU254739 Genomic DNA. Translation: ABX84172.1 .
EU254740 Genomic DNA. Translation: ABX84173.1 .
EU254741 Genomic DNA. Translation: ABX84174.1 .
EU254742 Genomic DNA. Translation: ABX84175.1 .
EU254743 Genomic DNA. Translation: ABX84176.1 .
RefSeqi YP_001504332.1. NC_009885.1.

3D structure databases

ProteinModelPortali Q8HEC3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5666631.
KEGGi cbr:COX2.

Organism-specific databases

CTDi 4513.

Phylogenomic databases

KOi K02261.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
    Denver D.R., Morris K., Thomas W.K.
    Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PB800.
  2. "Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution."
    Howe D.K., Denver D.R.
    BMC Evol. Biol. 8:62-62(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-16; THR-21; LEU-61; ALA-141 AND HIS-142.
    Strain: BW287, ED3032, ED3033, ED3034, ED3035, ED3036, ED3037, ED3083, ED3092, ED3101, EG4181, EG4207A, HK104, HK105, JU403, JU439, JU516, JU725, JU726, JU793, PB800, PB826 and VT847.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.
  4. "Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
    Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
    Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-231, VARIANT MET-16.
    Strain: AF16, HK104, HK105, PB800, PB826 and VT847.
  5. "An entomopathogenic Caenorhabditis."
    Thomas W.K., Abebe E.B., Jumba M., Gray V., Bonner K., Morris K.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-230, VARIANT MET-16.
    Strain: AF16, DR1690, HK104, HK105, JU725, JU726, KT0001, PB800, PB826 and VT847.

Entry informationi

Entry nameiCOX2_CAEBR
AccessioniPrimary (citable) accession number: Q8HEC3
Secondary accession number(s): A9YMI3
, A9YMI8, A9YMI9, B1PE42, B1PE54, B1PED8, B1PEH4, B1PEL0, Q8SEN0, Q8SFX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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