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Protein

Cytochrome c oxidase subunit 2

Gene

cox-2

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds a copper A center.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi164 – 1641Copper ACurated
Metal bindingi199 – 1991Copper ACurated
Metal bindingi203 – 2031Copper ACurated
Metal bindingi207 – 2071Copper ACurated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:cox-2
Synonyms:coII
Encoded oniMitochondrionImported
OrganismiCaenorhabditis briggsaeImported
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549 Componenti: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Topological domaini52 – 6413Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei65 – 8521HelicalSequence AnalysisAdd
BLAST
Topological domaini86 – 231146Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Cytochrome c oxidase subunit 2PRO_0000183525Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8HEC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ8HEC3.
KOiK02261.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8HEC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFFQGYNL LFQHSLFASY MDWFHAFNCS LLLGVLVFVT LLFGYLIFST
60 70 80 90 100
FYFKSKKIEY QFGELLCSIF PTIILLMQMV PSLSLLYYYG LMNLDSNLTV
110 120 130 140 150
KVTGHQWYWS YEYSDIPGLE FDSYMKSLDQ LNLGEPRLLE VDNRCVIPCD
160 170 180 190 200
TNIRFCITSA DVIHAWALNS LSVKLDAMSG ILSTFSYSFP MVGVFYGQCS
210 220 230
EICGANHSFM PIALEVTLLD NFKSWCFGTM E
Length:231
Mass (Da):26,590
Last modified:March 1, 2003 - v1
Checksum:i646AA84FD14D11E0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161L → M in strain: PB826. 3 Publications
Natural varianti21 – 211M → T in strain: ED3092 and ED3101. 1 Publication
Natural varianti61 – 611Q → L in strain: BW287. 1 Publication
Natural varianti141 – 1411V → A in strain: JU403. 1 Publication
Natural varianti142 – 1421D → H in strain: EG4207A. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171103 Genomic DNA. Translation: AAO13510.1.
EU407781 Genomic DNA. Translation: ACB06109.1.
EU407782 Genomic DNA. Translation: ACB06121.1.
EU407783 Genomic DNA. Translation: ACB06133.1.
EU407784 Genomic DNA. Translation: ACB06145.1.
EU407785 Genomic DNA. Translation: ACB06157.1.
EU407786 Genomic DNA. Translation: ACB06169.1.
EU407787 Genomic DNA. Translation: ACB06181.1.
EU407788 Genomic DNA. Translation: ACB06193.1.
EU407789 Genomic DNA. Translation: ACB06205.1.
EU407790 Genomic DNA. Translation: ACB06217.1.
EU407791 Genomic DNA. Translation: ACB06229.1.
EU407792 Genomic DNA. Translation: ACB06241.1.
EU407793 Genomic DNA. Translation: ACB06253.1.
EU407794 Genomic DNA. Translation: ACB06265.1.
EU407795 Genomic DNA. Translation: ACB06277.1.
EU407796 Genomic DNA. Translation: ACB06289.1.
EU407797 Genomic DNA. Translation: ACB06301.1.
EU407798 Genomic DNA. Translation: ACB06313.1.
EU407799 Genomic DNA. Translation: ACB06325.1.
EU407800 Genomic DNA. Translation: ACB06337.1.
EU407801 Genomic DNA. Translation: ACB06349.1.
EU407802 Genomic DNA. Translation: ACB06361.1.
EU407803 Genomic DNA. Translation: ACB06373.1.
AC186293 Genomic DNA. No translation available.
AF491452 Genomic DNA. Translation: AAM09746.1.
AF491453 Genomic DNA. Translation: AAM09747.1.
AF491454 Genomic DNA. Translation: AAM09748.1.
AF491455 Genomic DNA. Translation: AAM09749.1.
AF491456 Genomic DNA. Translation: AAM09750.1.
AF491457 Genomic DNA. Translation: AAM09751.1.
EU254734 Genomic DNA. Translation: ABX84167.1.
EU254735 Genomic DNA. Translation: ABX84168.1.
EU254736 Genomic DNA. Translation: ABX84169.1.
EU254737 Genomic DNA. Translation: ABX84170.1.
EU254738 Genomic DNA. Translation: ABX84171.1.
EU254739 Genomic DNA. Translation: ABX84172.1.
EU254740 Genomic DNA. Translation: ABX84173.1.
EU254741 Genomic DNA. Translation: ABX84174.1.
EU254742 Genomic DNA. Translation: ABX84175.1.
EU254743 Genomic DNA. Translation: ABX84176.1.
RefSeqiYP_001504332.1. NC_009885.1.

Genome annotation databases

GeneIDi5666631.
KEGGicbr:COX2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY171103 Genomic DNA. Translation: AAO13510.1.
EU407781 Genomic DNA. Translation: ACB06109.1.
EU407782 Genomic DNA. Translation: ACB06121.1.
EU407783 Genomic DNA. Translation: ACB06133.1.
EU407784 Genomic DNA. Translation: ACB06145.1.
EU407785 Genomic DNA. Translation: ACB06157.1.
EU407786 Genomic DNA. Translation: ACB06169.1.
EU407787 Genomic DNA. Translation: ACB06181.1.
EU407788 Genomic DNA. Translation: ACB06193.1.
EU407789 Genomic DNA. Translation: ACB06205.1.
EU407790 Genomic DNA. Translation: ACB06217.1.
EU407791 Genomic DNA. Translation: ACB06229.1.
EU407792 Genomic DNA. Translation: ACB06241.1.
EU407793 Genomic DNA. Translation: ACB06253.1.
EU407794 Genomic DNA. Translation: ACB06265.1.
EU407795 Genomic DNA. Translation: ACB06277.1.
EU407796 Genomic DNA. Translation: ACB06289.1.
EU407797 Genomic DNA. Translation: ACB06301.1.
EU407798 Genomic DNA. Translation: ACB06313.1.
EU407799 Genomic DNA. Translation: ACB06325.1.
EU407800 Genomic DNA. Translation: ACB06337.1.
EU407801 Genomic DNA. Translation: ACB06349.1.
EU407802 Genomic DNA. Translation: ACB06361.1.
EU407803 Genomic DNA. Translation: ACB06373.1.
AC186293 Genomic DNA. No translation available.
AF491452 Genomic DNA. Translation: AAM09746.1.
AF491453 Genomic DNA. Translation: AAM09747.1.
AF491454 Genomic DNA. Translation: AAM09748.1.
AF491455 Genomic DNA. Translation: AAM09749.1.
AF491456 Genomic DNA. Translation: AAM09750.1.
AF491457 Genomic DNA. Translation: AAM09751.1.
EU254734 Genomic DNA. Translation: ABX84167.1.
EU254735 Genomic DNA. Translation: ABX84168.1.
EU254736 Genomic DNA. Translation: ABX84169.1.
EU254737 Genomic DNA. Translation: ABX84170.1.
EU254738 Genomic DNA. Translation: ABX84171.1.
EU254739 Genomic DNA. Translation: ABX84172.1.
EU254740 Genomic DNA. Translation: ABX84173.1.
EU254741 Genomic DNA. Translation: ABX84174.1.
EU254742 Genomic DNA. Translation: ABX84175.1.
EU254743 Genomic DNA. Translation: ABX84176.1.
RefSeqiYP_001504332.1. NC_009885.1.

3D structure databases

ProteinModelPortaliQ8HEC3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5666631.
KEGGicbr:COX2.

Organism-specific databases

CTDi4513.

Phylogenomic databases

InParanoidiQ8HEC3.
KOiK02261.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing."
    Denver D.R., Morris K., Thomas W.K.
    Mol. Biol. Evol. 20:393-400(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PB800.
  2. "Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution."
    Howe D.K., Denver D.R.
    BMC Evol. Biol. 8:62-62(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS MET-16; THR-21; LEU-61; ALA-141 AND HIS-142.
    Strain: BW287, ED3032, ED3033, ED3034, ED3035, ED3036, ED3037, ED3083, ED3092, ED3101, EG4181, EG4207A, HK104, HK105, JU403, JU439, JU516, JU725, JU726, JU793, PB800, PB826 and VT847.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.
  4. "Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis."
    Graustein A., Gaspar J.M., Walters J.R., Palopoli M.F.
    Genetics 161:99-107(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-231, VARIANT MET-16.
    Strain: AF16, HK104, HK105, PB800, PB826 and VT847.
  5. "An entomopathogenic Caenorhabditis."
    Thomas W.K., Abebe E.B., Jumba M., Gray V., Bonner K., Morris K.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-230, VARIANT MET-16.
    Strain: AF16, DR1690, HK104, HK105, JU725, JU726, KT0001, PB800, PB826 and VT847.

Entry informationi

Entry nameiCOX2_CAEBR
AccessioniPrimary (citable) accession number: Q8HEC3
Secondary accession number(s): A9YMI3
, A9YMI8, A9YMI9, B1PE42, B1PE54, B1PED8, B1PEH4, B1PEL0, Q8SEN0, Q8SFX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.