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Protein

Probable apyrase 1

Gene

APY1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of phosphoanhydride bonds of nucleoside tri- and di-phosphates.By similarity

Catalytic activityi

A nucleoside 5'-triphosphate + 2 H2O = a nucleoside 5'-phosphate + 2 phosphate.

Cofactori

Ca2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei211Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi89 – 99ATP-bindingCuratedAdd BLAST11
Nucleotide bindingi235 – 245ATP-bindingCuratedAdd BLAST11

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable apyrase 1 (EC:3.6.1.5)
Short name:
OsAPY1
Alternative name(s):
ATP-diphosphatase
ATP-diphosphohydrolase
Adenosine diphosphatase
Short name:
ADPase
Gene namesi
Name:APY1
Ordered Locus Names:Os03g0328400, LOC_Os03g21120
ORF Names:OSJNBb0014I10.10
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini50 – 489ExtracellularSequence analysisAdd BLAST440

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004199071 – 489Probable apyrase 1Add BLAST489

Proteomic databases

PaxDbiQ8H7L6.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g21120.1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 16Poly-Gln5
Compositional biasi368 – 373Poly-Gly6

Sequence similaritiesi

Belongs to the GDA1/CD39 NTPase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1385. Eukaryota.
COG5371. LUCA.
InParanoidiQ8H7L6.
KOiK14641.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8H7L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRFSAAAGA RQQQQQGEAV SDRVLRFRGV LVVVLAPVLL ISLVLLLMPR
60 70 80 90 100
APASATVEGS AGELVAAAGR RWGPRAVSGL GDGSTRYAVI FDAGSSGSRV
110 120 130 140 150
HVYCFDGNLD LLPIGKEIEL FKQKKPGLSA YAMDPQEAAK SLVSLLEEAE
160 170 180 190 200
KVIPVELREQ TPVRVGATAG LRALGTEKSE EILQAVRDLL QDKSSFRSQP
210 220 230 240 250
EWVTVLDGSQ EGAFQWVTIN YLLGNLGKPY SHTVGVVDLG GGSVQMAYAI
260 270 280 290 300
SEKDAGKAPP VAEGEDSYVK ELLLKGTTYY LYVHSYLRYG LLAARAEILK
310 320 330 340 350
AGEGNDYRNC MLEGHHGQYR YGDDIFEASG LSSGASYSKC RAVAVRALKV
360 370 380 390 400
DEPACTHMKC TFGGVWNGGG GDGQKNLFVA SFFFDRAAEA GFVNPKAPFA
410 420 430 440 450
KVKPSDFEEA ARRVCKLNVK DAQATYPDVS EENVPYLCMD LVYQYTLLVD
460 470 480
GFGVDPYQDI TLVKKVPYSN SFVEAAWPLG SAIEVASSS
Length:489
Mass (Da):52,799
Last modified:March 1, 2003 - v1
Checksum:i0BF6BF154488D38E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126222 Genomic DNA. Translation: AAN65004.1.
DP000009 Genomic DNA. Translation: ABF95735.1.
AP014959 Genomic DNA. No translation available.
RefSeqiXP_015632681.1. XM_015777195.1.

Genome annotation databases

GeneIDi4332721.
KEGGiosa:4332721.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126222 Genomic DNA. Translation: AAN65004.1.
DP000009 Genomic DNA. Translation: ABF95735.1.
AP014959 Genomic DNA. No translation available.
RefSeqiXP_015632681.1. XM_015777195.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g21120.1.

Proteomic databases

PaxDbiQ8H7L6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4332721.
KEGGiosa:4332721.

Phylogenomic databases

eggNOGiKOG1385. Eukaryota.
COG5371. LUCA.
InParanoidiQ8H7L6.
KOiK14641.

Family and domain databases

InterProiIPR000407. GDA1_CD39_NTPase.
[Graphical view]
PANTHERiPTHR11782. PTHR11782. 2 hits.
PfamiPF01150. GDA1_CD39. 1 hit.
[Graphical view]
PROSITEiPS01238. GDA1_CD39_NTPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPY1_ORYSJ
AccessioniPrimary (citable) accession number: Q8H7L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.