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Q8H7F6

- GRS16_ARATH

UniProt

Q8H7F6 - GRS16_ARATH

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Protein

Monothiol glutaredoxin-S16, chloroplastic

Gene

GRXS16

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May only reduce GSH-thiol disulfides, but not protein disulfides.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei211 – 2111GlutathioneBy similarity
Metal bindingi219 – 2191Iron-sulfur (2Fe-2S); shared with dimeric partnerBy similarity
Binding sitei251 – 2511GlutathioneBy similarity
Binding sitei263 – 2631Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. electron carrier activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cation transport Source: TAIR
  2. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Monothiol glutaredoxin-S16, chloroplastic
Short name:
AtGrxS16
Alternative name(s):
CAXIP1-like protein
Gene namesi
Name:GRXS16
Ordered Locus Names:At2g38270
ORF Names:F16M14.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G38270.

Subcellular locationi

Plastidchloroplast Curated

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. chloroplast stroma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6262ChloroplastSequence AnalysisAdd
BLAST
Chaini63 – 293231Monothiol glutaredoxin-S16, chloroplasticPRO_0000268736Add
BLAST

Proteomic databases

PaxDbiQ8H7F6.
PRIDEiQ8H7F6.

Expressioni

Gene expression databases

GenevestigatoriQ8H7F6.

Interactioni

Protein-protein interaction databases

BioGridi3749. 12 interactions.
IntActiQ8H7F6. 7 interactions.
STRINGi3702.AT2G38270.1-P.

Structurei

Secondary structure

1
293
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 713
Beta strandi73 – 775
Helixi80 – 823
Beta strandi86 – 938
Beta strandi99 – 1068
Helixi108 – 11811
Helixi120 – 1223
Beta strandi124 – 1307
Helixi136 – 15318
Turni159 – 1635
Turni167 – 1693

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LWFNMR-A63-170[»]
ProteinModelPortaliQ8H7F6.
SMRiQ8H7F6. Positions 62-172, 195-292.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 293100GlutaredoxinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni276 – 2772Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the glutaredoxin family. CGFS subfamily.Curated
Contains 1 glutaredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

eggNOGiCOG0278.
HOGENOMiHOG000243994.
InParanoidiQ8H7F6.
OMAiYNYGLRE.
PhylomeDBiQ8H7F6.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR002109. Glutaredoxin.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR10293. PTHR10293. 1 hit.
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00365. TIGR00365. 1 hit.
PROSITEiPS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8H7F6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAITISSSL HASASPRVVR PHVSRNTPVI TLYSRFTPSF SFPSLSFTLR
60 70 80 90 100
DTAPSRRRSF FIASAVKSLT ETELLPITEA DSIPSASGVY AVYDKSDELQ
110 120 130 140 150
FVGISRNIAA SVSAHLKSVP ELCGSVKVGI VEEPDKAVLT QAWKLWIEEH
160 170 180 190 200
IKVTGKVPPG NKSGNNTFVK QTPRKKSDIR LTPGRHVELT VPLEELIDRL
210 220 230 240 250
VKESKVVAFI KGSRSAPQCG FSQRVVGILE SQGVDYETVD VLDDEYNHGL
260 270 280 290
RETLKNYSNW PTFPQIFVKG ELVGGCDILT SMYENGELAN ILN
Length:293
Mass (Da):32,206
Last modified:December 12, 2006 - v2
Checksum:i6B2E6337F8C5F050
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti194 – 1941E → G in AAN60257. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY157989 mRNA. Translation: AAO19648.1.
AF083698 mRNA. Translation: AAN60257.1.
AC003028 Genomic DNA. Translation: AAC27175.1.
CP002685 Genomic DNA. Translation: AEC09515.1.
AK117441 mRNA. Translation: BAC42106.1.
BT004974 mRNA. Translation: AAO50507.1.
AY086273 mRNA. Translation: AAM64346.1.
PIRiT01258.
RefSeqiNP_565885.1. NM_129383.2.
UniGeneiAt.25559.
At.71438.

Genome annotation databases

EnsemblPlantsiAT2G38270.1; AT2G38270.1; AT2G38270.
GeneIDi818407.
KEGGiath:AT2G38270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY157989 mRNA. Translation: AAO19648.1 .
AF083698 mRNA. Translation: AAN60257.1 .
AC003028 Genomic DNA. Translation: AAC27175.1 .
CP002685 Genomic DNA. Translation: AEC09515.1 .
AK117441 mRNA. Translation: BAC42106.1 .
BT004974 mRNA. Translation: AAO50507.1 .
AY086273 mRNA. Translation: AAM64346.1 .
PIRi T01258.
RefSeqi NP_565885.1. NM_129383.2.
UniGenei At.25559.
At.71438.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LWF NMR - A 63-170 [» ]
ProteinModelPortali Q8H7F6.
SMRi Q8H7F6. Positions 62-172, 195-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 3749. 12 interactions.
IntActi Q8H7F6. 7 interactions.
STRINGi 3702.AT2G38270.1-P.

Proteomic databases

PaxDbi Q8H7F6.
PRIDEi Q8H7F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G38270.1 ; AT2G38270.1 ; AT2G38270 .
GeneIDi 818407.
KEGGi ath:AT2G38270.

Organism-specific databases

TAIRi AT2G38270.

Phylogenomic databases

eggNOGi COG0278.
HOGENOMi HOG000243994.
InParanoidi Q8H7F6.
OMAi YNYGLRE.
PhylomeDBi Q8H7F6.

Gene expression databases

Genevestigatori Q8H7F6.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR002109. Glutaredoxin.
IPR004480. Monothiol_GRX-rel.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR10293. PTHR10293. 1 hit.
Pfami PF00462. Glutaredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR00365. TIGR00365. 1 hit.
PROSITEi PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of CXIP1 A novel PICOT domain-containing Arabidopsis protein that associates with CAX1."
    Cheng N.-H., Hirschi K.D.
    J. Biol. Chem. 278:6503-6509(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Signal peptide selection derived cDNAs from Arabidopsis thaliana leaves and guard cells."
    Stracke R., Palme K.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  4. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  7. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. "Plant glutaredoxins: still mysterious reducing systems."
    Rouhier N., Gelhaye E., Jacquot J.-P.
    Cell. Mol. Life Sci. 61:1266-1277(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  9. "Genome-wide analysis of plant glutaredoxin systems."
    Rouhier N., Couturier J., Jacquot J.-P.
    J. Exp. Bot. 57:1685-1696(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiGRS16_ARATH
AccessioniPrimary (citable) accession number: Q8H7F6
Secondary accession number(s): O80451, Q8LD13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: October 1, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3