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Protein

Chalcone synthase 2

Gene

CHS2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.By similarity

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168Acyl-thioester intermediatePROSITE-ProRule annotation1
Binding sitei313Coenzyme A; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 2 (EC:2.3.1.74)
Short name:
OsCHS2
Alternative name(s):
Naregenin-chalcone synthase
Gene namesi
Name:CHS2
Ordered Locus Names:Os07g0214900, LOC_Os07g11440
ORF Names:OJ1116_C08.125
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004073271 – 403Chalcone synthase 2Add BLAST403

Proteomic databases

PaxDbiQ8H4L3

Expressioni

Gene expression databases

ExpressionAtlasiQ8H4L3 differential

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os07g11440.1

Structurei

3D structure databases

ProteinModelPortaliQ8H4L3
SMRiQ8H4L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni59 – 66Coenzyme A bindingBy similarity8
Regioni220 – 221Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiENOG410IKZU Eukaryota
COG3424 LUCA
InParanoidiQ8H4L3
KOiK00660
OMAiICAEITV
OrthoDBiEOG09360E8Q

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR012328 Chalcone/stilbene_synth_C
IPR018088 Chalcone/stilbene_synthase_AS
IPR001099 Chalcone/stilbene_synthase_N
IPR011141 Polyketide_synthase_type-III
IPR016039 Thiolase-like
PANTHERiPTHR11877 PTHR11877, 1 hit
PfamiView protein in Pfam
PF02797 Chal_sti_synt_C, 1 hit
PF00195 Chal_sti_synt_N, 1 hit
PIRSFiPIRSF000451 PKS_III, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
PROSITEiView protein in PROSITE
PS00441 CHALCONE_SYNTH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8H4L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSTVKLEE VRRMQRAEGM AAVLAIGTAT PANCVYQTDY PDYYFRVTNS
60 70 80 90 100
EHLTNLKERF QRMCESSQIR KRYTHLTEEI LQENPSMCVF TAPSLDARQD
110 120 130 140 150
MVVAEVPKLG KAAAEEAIKE WGQPMSRITH LVFCTTNGVD MPGADYQVAK
160 170 180 190 200
MLGLPTSVKR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEIMAM
210 220 230 240 250
AFRGPSESHL DSLVGHALFG DGAAAVIVGS DPDEAADERP LFQIVSASQT
260 270 280 290 300
ILPGTEDAIV GHLREVGLTF HLPKDVPEFI SDSVEGALTD AFMPLGVHDW
310 320 330 340 350
NSIFWVVHPG GPAILDQVEE KVALHKARMR ASRNVLSEYG NMASATVLFV
360 370 380 390 400
LDEMRKLSAD DGHATTGEGM DWGVLFGFGP GLTVETIVLH SVPITAAAPL

IMQ
Length:403
Mass (Da):43,925
Last modified:March 1, 2003 - v1
Checksum:i1E2622C4769F7B62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP004002 Genomic DNA Translation: BAC20662.1
AP008213 Genomic DNA Translation: BAF21101.1
AP014963 Genomic DNA Translation: BAT00622.1
RefSeqiXP_015646206.1, XM_015790720.1

Genome annotation databases

EnsemblPlantsiOs07t0214900-00; Os07t0214900-00; Os07g0214900
GeneIDi4342725
GrameneiOs07t0214900-00; Os07t0214900-00; Os07g0214900
KEGGiosa:4342725

Similar proteinsi

Entry informationi

Entry nameiCHS2_ORYSJ
AccessioniPrimary (citable) accession number: Q8H4L3
Secondary accession number(s): A0A0P0X3Z1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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