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Q8H4L3

- CHS2_ORYSJ

UniProt

Q8H4L3 - CHS2_ORYSJ

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Protein

Chalcone synthase 2

Gene

CHS2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.By similarity

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei168 – 1681Acyl-thioester intermediatePROSITE-ProRule annotation
Binding sitei313 – 3131Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 2 (EC:2.3.1.74)
Short name:
OsCHS2
Alternative name(s):
Naregenin-chalcone synthase
Gene namesi
Name:CHS2
Ordered Locus Names:Os07g0214900, LOC_Os07g11440
ORF Names:OJ1116_C08.125
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 7

Organism-specific databases

GrameneiQ8H4L3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Chalcone synthase 2PRO_0000407327Add
BLAST

Proteomic databases

PRIDEiQ8H4L3.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8H4L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni59 – 668Coenzyme A bindingBy similarity
Regioni220 – 2212Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Phylogenomic databases

eggNOGiCOG3424.
InParanoidiQ8H4L3.
OMAiIMAMAFR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8H4L3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTSTVKLEE VRRMQRAEGM AAVLAIGTAT PANCVYQTDY PDYYFRVTNS
60 70 80 90 100
EHLTNLKERF QRMCESSQIR KRYTHLTEEI LQENPSMCVF TAPSLDARQD
110 120 130 140 150
MVVAEVPKLG KAAAEEAIKE WGQPMSRITH LVFCTTNGVD MPGADYQVAK
160 170 180 190 200
MLGLPTSVKR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEIMAM
210 220 230 240 250
AFRGPSESHL DSLVGHALFG DGAAAVIVGS DPDEAADERP LFQIVSASQT
260 270 280 290 300
ILPGTEDAIV GHLREVGLTF HLPKDVPEFI SDSVEGALTD AFMPLGVHDW
310 320 330 340 350
NSIFWVVHPG GPAILDQVEE KVALHKARMR ASRNVLSEYG NMASATVLFV
360 370 380 390 400
LDEMRKLSAD DGHATTGEGM DWGVLFGFGP GLTVETIVLH SVPITAAAPL

IMQ
Length:403
Mass (Da):43,925
Last modified:March 1, 2003 - v1
Checksum:i1E2622C4769F7B62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP004002 Genomic DNA. Translation: BAC20662.1.
AP008213 Genomic DNA. Translation: BAF21101.1.
RefSeqiNP_001059187.1. NM_001065722.1.
UniGeneiOs.78839.

Genome annotation databases

EnsemblPlantsiOS07T0214900-00; OS07T0214900-00; OS07G0214900.
GeneIDi4342725.
KEGGiosa:4342725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP004002 Genomic DNA. Translation: BAC20662.1 .
AP008213 Genomic DNA. Translation: BAF21101.1 .
RefSeqi NP_001059187.1. NM_001065722.1.
UniGenei Os.78839.

3D structure databases

ProteinModelPortali Q8H4L3.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8H4L3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS07T0214900-00 ; OS07T0214900-00 ; OS07G0214900 .
GeneIDi 4342725.
KEGGi osa:4342725.

Organism-specific databases

Gramenei Q8H4L3.

Phylogenomic databases

eggNOGi COG3424.
InParanoidi Q8H4L3.
OMAi IMAMAFR.

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiCHS2_ORYSJ
AccessioniPrimary (citable) accession number: Q8H4L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3