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Q8H4L3

- CHS2_ORYSJ

UniProt

Q8H4L3 - CHS2_ORYSJ

Protein

Chalcone synthase 2

Gene

CHS2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.By similarity

    Catalytic activityi

    3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei168 – 1681Acyl-thioester intermediatePROSITE-ProRule annotation
    Binding sitei313 – 3131Coenzyme A; via amide nitrogenBy similarity

    GO - Molecular functioni

    1. naringenin-chalcone synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00154.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chalcone synthase 2 (EC:2.3.1.74)
    Short name:
    OsCHS2
    Alternative name(s):
    Naregenin-chalcone synthase
    Gene namesi
    Name:CHS2
    Ordered Locus Names:Os07g0214900, LOC_Os07g11440
    ORF Names:OJ1116_C08.125
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 7

    Organism-specific databases

    GrameneiQ8H4L3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Chalcone synthase 2PRO_0000407327Add
    BLAST

    Proteomic databases

    PRIDEiQ8H4L3.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8H4L3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 668Coenzyme A bindingBy similarity
    Regioni220 – 2212Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the chalcone/stilbene synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG3424.
    OMAiIMAMAFR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000451. PKS_III. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8H4L3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTSTVKLEE VRRMQRAEGM AAVLAIGTAT PANCVYQTDY PDYYFRVTNS    50
    EHLTNLKERF QRMCESSQIR KRYTHLTEEI LQENPSMCVF TAPSLDARQD 100
    MVVAEVPKLG KAAAEEAIKE WGQPMSRITH LVFCTTNGVD MPGADYQVAK 150
    MLGLPTSVKR LMMYQQGCFA GGTVLRVAKD LAENNRGARV LVVCSEIMAM 200
    AFRGPSESHL DSLVGHALFG DGAAAVIVGS DPDEAADERP LFQIVSASQT 250
    ILPGTEDAIV GHLREVGLTF HLPKDVPEFI SDSVEGALTD AFMPLGVHDW 300
    NSIFWVVHPG GPAILDQVEE KVALHKARMR ASRNVLSEYG NMASATVLFV 350
    LDEMRKLSAD DGHATTGEGM DWGVLFGFGP GLTVETIVLH SVPITAAAPL 400
    IMQ 403
    Length:403
    Mass (Da):43,925
    Last modified:March 1, 2003 - v1
    Checksum:i1E2622C4769F7B62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004002 Genomic DNA. Translation: BAC20662.1.
    AP008213 Genomic DNA. Translation: BAF21101.1.
    RefSeqiNP_001059187.1. NM_001065722.1.
    UniGeneiOs.78839.

    Genome annotation databases

    EnsemblPlantsiOS07T0214900-00; OS07T0214900-00; OS07G0214900.
    GeneIDi4342725.
    KEGGiosa:4342725.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP004002 Genomic DNA. Translation: BAC20662.1 .
    AP008213 Genomic DNA. Translation: BAF21101.1 .
    RefSeqi NP_001059187.1. NM_001065722.1.
    UniGenei Os.78839.

    3D structure databases

    ProteinModelPortali Q8H4L3.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8H4L3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi OS07T0214900-00 ; OS07T0214900-00 ; OS07G0214900 .
    GeneIDi 4342725.
    KEGGi osa:4342725.

    Organism-specific databases

    Gramenei Q8H4L3.

    Phylogenomic databases

    eggNOGi COG3424.
    OMAi IMAMAFR.

    Enzyme and pathway databases

    UniPathwayi UPA00154 .

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR012328. Chalcone/stilbene_synth_C.
    IPR018088. Chalcone/stilbene_synthase_AS.
    IPR001099. Chalcone/stilbene_synthase_N.
    IPR011141. Polyketide_synthase_type-III.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF02797. Chal_sti_synt_C. 1 hit.
    PF00195. Chal_sti_synt_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000451. PKS_III. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.
    2. "The rice annotation project database (RAP-DB): 2008 update."
      The rice annotation project (RAP)
      Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: cv. Nipponbare.
    3. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
      The rice full-length cDNA consortium
      Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiCHS2_ORYSJ
    AccessioniPrimary (citable) accession number: Q8H4L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3