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Q8H3I4

- GLO4_ORYSJ

UniProt

Q8H3I4 - GLO4_ORYSJ

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Protein
Peroxisomal (S)-2-hydroxy-acid oxidase GLO4
Gene
GLO4, Os07g0616500, B1056G08.112, OsJ_25131
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Photorespiratory enzyme that can exert a strong regulation over photosynthesis, possibly through a feed-back inhibition on Rubisco activase. Not required for oxalate accumulation By similarity.

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMN By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 271Substrate Reviewed prediction
Binding sitei109 – 1091FMN By similarity
Binding sitei130 – 1301FMN By similarity
Binding sitei132 – 1321Substrate By similarity
Binding sitei158 – 1581FMN By similarity
Binding sitei167 – 1671Substrate By similarity
Binding sitei231 – 2311FMN By similarity
Active sitei255 – 2551Proton acceptor By similarity
Binding sitei258 – 2581Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi286 – 31025FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. glycolate oxidase activity Source: UniProtKB
  3. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
  4. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
  5. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. defense response signaling pathway, resistance gene-independent Source: EnsemblPlants/Gramene
  2. defense response to bacterium Source: EnsemblPlants/Gramene
  3. hydrogen peroxide biosynthetic process Source: EnsemblPlants/Gramene
  4. modulation by virus of host morphology or physiology Source: UniProtKB
  5. oxidative photosynthetic carbon pathway Source: UniProtKB-UniPathway
  6. photorespiration Source: UniProtKB
  7. regulation of photosynthesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolate pathway, Host-virus interaction, Photorespiration

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

UniPathwayiUPA00951; UER00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal (S)-2-hydroxy-acid oxidase GLO4 (EC:1.1.3.15)
Alternative name(s):
Glycolate oxidase 4
Short name:
GOX 4
Short name:
OsGLO4
Short chain alpha-hydroxy acid oxidase GLO4
Gene namesi
Name:GLO4
Ordered Locus Names:Os07g0616500
ORF Names:B1056G08.112, OsJ_25131
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 7

Organism-specific databases

GrameneiQ8H3I4.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Peroxisomal (S)-2-hydroxy-acid oxidase GLO4
PRO_0000403415Add
BLAST

Interactioni

Subunit structurei

Homotetramer or homooctamer. Interacts with rice dwarf virus (RDV) P8. This interaction promotes viral P8 relocation to virus factories peripheral to peroxisomes By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8H3I4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 360360FMN hydroxy acid dehydrogenase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi364 – 3663Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
KOiK11517.
OMAiAKAVMIG.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8H3I4-1 [UniParc]FASTAAdd to Basket

« Hide

MEDNLPVNVR EYQELAKKAL PKMAYDYING GAEDEHTLRE NIAAYTRIIL    50
RPRVLVDVSK IDMSTTLLGY TMRSPIIVAP TGGHKLAHPE GEKATARAAA 100
SCNAIMVLSF SSSCKIEDVA SSCNAIRFYQ LYVYKNRNVS ATLVRRAESC 150
GFKALLLTVD TPMLGRREAD IRNKMVFPRS GNLEGLMTTD DHDTTNGSQL 200
ERFARATLDP SLSWKDIEWL KSITSMPIFL KGIVTAEDAR RAVEAGVAGV 250
IVSNHGARQL DYAPATIAAL EEVVRAVAGA VPVLVDGGIR RGTDVFKALA 300
LGARAVMVGR PVFFGLAARG EAGARHVIEM LNGELEVAMA LCGCRSVGEI 350
TRSHVMTEGD RIRSLL 366
Length:366
Mass (Da):39,764
Last modified:October 1, 2003 - v2
Checksum:i73FCBAD72CC9B9F5
GO

Sequence cautioni

The sequence EEE67592.1 differs from that shown. Reason: Frameshift at position 321.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti313 – 3131F → L in EEE67592. 1 Publication
Sequence conflicti321 – 3211E → D in EEE67592. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP004988 Genomic DNA. Translation: BAC79990.1.
AP008213 Genomic DNA. Translation: BAF22190.1.
CM000144 Genomic DNA. Translation: EEE67592.1. Frameshift.
AK071738 mRNA. Translation: BAG92663.1.
RefSeqiNP_001060276.1. NM_001066811.1.
UniGeneiOs.8126.

Genome annotation databases

EnsemblPlantsiOS07T0616500-01; OS07T0616500-01; OS07G0616500.
GeneIDi4343908.
KEGGiosa:4343908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP004988 Genomic DNA. Translation: BAC79990.1 .
AP008213 Genomic DNA. Translation: BAF22190.1 .
CM000144 Genomic DNA. Translation: EEE67592.1 . Frameshift.
AK071738 mRNA. Translation: BAG92663.1 .
RefSeqi NP_001060276.1. NM_001066811.1.
UniGenei Os.8126.

3D structure databases

ProteinModelPortali Q8H3I4.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS07T0616500-01 ; OS07T0616500-01 ; OS07G0616500 .
GeneIDi 4343908.
KEGGi osa:4343908.

Organism-specific databases

Gramenei Q8H3I4.

Phylogenomic databases

eggNOGi COG1304.
KOi K11517.
OMAi AKAVMIG.

Enzyme and pathway databases

UniPathwayi UPA00951 ; UER00912 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  3. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  5. "Inducible antisense suppression of glycolate oxidase reveals its strong regulation over photosynthesis in rice."
    Xu H.-W., Zhang J., Zeng J., Jiang L., Liu E., Peng C., He Z.-H., Peng X.-X.
    J. Exp. Bot. 60:1799-1809(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGLO4_ORYSJ
AccessioniPrimary (citable) accession number: Q8H3I4
Secondary accession number(s): B9FU85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: October 1, 2003
Last modified: May 14, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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