Q8H2C9 (PROF1_ARTVU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Profilin-1 Alternative name(s): Pollen allergen Art v 4.01 Allergen=Art v 4.01
Organism	Artemisia vulgaris (Mugwort)
Taxonomic identifier	4220 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Anthemideae › Artemisiinae › Artemisia

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Dimer and tetramer. Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Ref.1
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the profilin family.
Mass spectrometry	Molecular mass is 14077 Da from positions 2 - 133. Determined by MALDI. Ref.1

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 133	132	Profilin-1		PRO_0000199620

Sequences

	Sequence		Length	Mass (Da)
	Q8H2C9 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 96FA8A3D7CA54E3D	FASTA	133	14,207
	10 20 30 40 50 60 MSWQTYVDDH LMCDIEGTGQ HLTSAAIFGT DGTVWAKSAS FPEFKPNEID AIIKEFNEAG 70 80 90 100 110 120 QLAPTGLFLG GAKYMVIQGE AGAVIRGKKG AGGICIKKTG QAMVFGIYDE PVAPGQCNMV 130 VERLGDYLLD QGM

References

[1]

"Molecular and immunological characterization of profilin from mugwort pollen." Wopfner N., Willeroidee M., Hebenstreit D., van Ree R., Aalbers M., Briza P., Thalhamer J., Ebner C., Richter K., Ferreira F. Biol. Chem. 383:1779-1789(2002) [PubMed: 12530543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBUNIT, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ421030 mRNA. Translation: CAD12861.1.
3D structure databases
ProteinModelPortal	Q8H2C9.
SMR	Q8H2C9. Positions 2-133.
ModBase	Search...
Protein family/group databases
Allergome	1652. Art v 4.0101. 60. Art v 4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002097. Profilin. IPR005455. Profilin_plant. [Graphical view]
PANTHER	PTHR11604. Profilin_plant. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF1_ARTVU

Accession

Primary (citable) accession number: Q8H2C9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	January 23, 2007
Last modified:	January 11, 2011
This is version 44 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program