Reviewed, UniProtKB/Swiss-Prot Q8H2C8 (PROF2_ARTVU)

Names and origin

Protein names	Recommended name:     Profilin-2 Alternative name(s):     Pollen allergen Art v 4.02     Allergen=Art v 4.02
Organism	Artemisia vulgaris (Mugwort)
Taxonomic identifier	4220 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Anthemideae › Artemisia

Protein attributes

Sequence length	133 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 133	132	Profilin-2		PRO_0000199621

Sequences

	Sequence		Length	Mass (Da)
	Q8H2C8-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 051DEDAF98E624F2	FASTA	133	14,315
	10 20 30 40 50 60 MSWQTYVDDH LMCDIEGTGQ HLTAAAILGL DGTVWAKSDK FPEFKPEEMK GIINEFNEVG 70 80 90 100 110 120 TLAPTGLFLG GAKYMVLQGE AGAVIRGKKG AGGICIKKTG QAMVMGIYDE PVAPGQCNMI 130 VERLGDYLVD QNM

References

[1]

"Molecular and immunological characterization of profilin from mugwort pollen." Wopfner N., Willeroidee M., Hebenstreit D., van Ree R., Aalbers M., Briza P., Thalhamer J., Ebner C., Richter K., Ferreira F. Biol. Chem. 383:1779-1789(2002) [PubMed: 12530543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pollen.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ421031 mRNA. Translation: CAD12862.1.
3D structure databases
HSSP	HSSP built from PDB template 1CQA based on UniProtKB P25816.
SMR	Q8H2C8. Positions 1-132, 2-133.
ModBase	Search...
Family and domain databases
InterPro	IPR002097. Profilin. IPR005455. Profilin_plant. [Graphical view]
PANTHER	PTHR11604. Profilin_plant. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF2_ARTVU

Accession

Primary (citable) accession number: Q8H2C8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	January 23, 2007
Last modified:	September 22, 2009
This is version 37 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)