Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anaphase-promoting complex subunit 2

Gene

APC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • megagametogenesis Source: UniProtKB
  • protein ubiquitination Source: UniProtKB-UniPathway
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Anaphase-promoting complex subunit 2
Alternative name(s):
Cyclosome subunit 2
Gene namesi
Name:APC2
Ordered Locus Names:At2g04660
ORF Names:F28I8.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT2G04660
TAIRilocus:2049173 AT2G04660

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Gametophytic lethal phenotype.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003968381 – 865Anaphase-promoting complex subunit 2Add BLAST865

Proteomic databases

PaxDbiQ8H1U5

Expressioni

Tissue specificityi

Highly expressed in immature flowers. Expressed in stems, leaves and flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ8H1U5 baseline and differential
GenevisibleiQ8H1U5 AT

Interactioni

Subunit structurei

The APC/C is composed of at least 10 subunits. Interacts with APC8, APC11, CDC27A and CDC27B.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi409, 18 interactors
IntActiQ8H1U5, 19 interactors
STRINGi3702.AT2G04660.1

Structurei

3D structure databases

ProteinModelPortaliQ8H1U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2165 Eukaryota
ENOG410XRBY LUCA
HOGENOMiHOG000265303
InParanoidiQ8H1U5
KOiK03349
OMAiWHSGMDI
OrthoDBiEOG093602UJ
PhylomeDBiQ8H1U5

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR014786 APC_su2_C
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF08672 ANAPC2, 1 hit
PF00888 Cullin, 1 hit
SMARTiView protein in SMART
SM01013 APC2, 1 hit
SM00182 CULLIN, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS50069 CULLIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8H1U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALGSSDCN LEILETLSDD AIQEITESYD GFFTTVESLI AGTGDSLVED
60 70 80 90 100
EFVSHVYCLC KYGLDSLVRD HFLRSLEQAF EKGGASSFWQ HFDAYSEKKH
110 120 130 140 150
HNYGEEIQIV LCKALEEISI EKQYHEKCLS IVVHALQSFK EQSSDDRQNS
160 170 180 190 200
DTERVHLFSR FQSMLSSTLM TTLPQHFPEI LHWYFKERLE ELSAIMDGDG
210 220 230 240 250
IEEQEDDCMD LDEKLRYKNG EMDVDEGCSQ GKRLGHDKLV KNIGKVVRDL
260 270 280 290 300
RSIGFTSMAE NAYASAIFLL LKAKVHDLAG DDYRTSVLES IKEWIQTVPL
310 320 330 340 350
QFLNALLSYL GDSVSYGTTS SGLTSPLACC PSPSFSRVVT PSEGIVRWKL
360 370 380 390 400
RLEYFAYETL QDLRIAKLFE IIVDYPESSP AIEDLKQCLE YTGQHSKLVE
410 420 430 440 450
SFISSLKYRL LTAGASTNDI LHQYVSTIKA LRAIDPAGVF LEAVGEPIRD
460 470 480 490 500
YLRGRKDTIK CIVTMLTDGS GGNANGSGNP GDSLLEELMR DEESQENVGF
510 520 530 540 550
DDDFHTDDKQ AWINASRWEP DPVEADPLKG SLSQRKVDIL GMLVDIIGSK
560 570 580 590 600
EQLVNEYRVM LAEKLLNKTD YDIDTEIRTV ELLKIHFGEA SMQRCEIMLN
610 620 630 640 650
DLIDSKRVNT NIKKASQTGA ELRENELSVD TLTSTILSTN FWPPIQDEPL
660 670 680 690 700
ELPGPVDKLL SDYANRYHEI KTPRKLLWKK NLGTVKLELQ FEDRAMQFTV
710 720 730 740 750
SPTHAAIIMQ FQEKKSWTYK DLAEVIGIPI DALNRRVNFW ISKGVLREST
760 770 780 790 800
GANSNSSVLT LVESITDSGK NEGEELLTGE EEGETSIASV EDQLRKEMTI
810 820 830 840 850
YEKFIMGMLT NFGSMALERI HNTLKMFCVA DPSYDKSLQQ LQSFLSGLVS
860
EEKLEFRDGM YLLKK
Length:865
Mass (Da):97,791
Last modified:March 1, 2003 - v1
Checksum:i277D9DD60E4399C3
GO

Sequence cautioni

The sequence AAD22340 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti247V → A in BAC43061 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006955 Genomic DNA Translation: AAD22340.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC05853.1
AK118453 mRNA Translation: BAC43061.1
AY138228 mRNA Translation: AAN10196.1
PIRiH84459
RefSeqiNP_178543.2, NM_126495.3
UniGeneiAt.41283

Genome annotation databases

EnsemblPlantsiAT2G04660.1; AT2G04660.1; AT2G04660
GeneIDi815008
GrameneiAT2G04660.1; AT2G04660.1; AT2G04660
KEGGiath:AT2G04660

Entry informationi

Entry nameiAPC2_ARATH
AccessioniPrimary (citable) accession number: Q8H1U5
Secondary accession number(s): Q8GX39, Q9SJ93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health