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Q8H1T3 (FRI2_TOBAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin-2, chloroplastic

EC=1.16.3.1
Alternative name(s):
NtFer2
Gene names
Name:FER2
OrganismNicotiana tabacum (Common tobacco)
Taxonomic identifier4097 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Subcellular location

Plastidchloroplast By similarity.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentChloroplast
Plastid
   DomainTransit peptide
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentchloroplast

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 5252Chloroplast Potential
Chain53 – 259207Ferritin-2, chloroplastic
PRO_0000008869

Regions

Domain86 – 239154Ferritin-like diiron
Region53 – 8533Extension peptide (EP)

Sites

Metal binding1031Iron 1 By similarity
Metal binding1381Iron 1 By similarity
Metal binding1381Iron 2 By similarity
Metal binding1411Iron 1 By similarity
Metal binding2211Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8H1T3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 59997A45142375C3

FASTA25929,220
        10         20         30         40         50         60 
MLLKLAPAFT LLNSHGENLS PMLSTSSQGF VLKNFSTKSR NGLLVVCASK GSNTKPLTGV 

        70         80         90        100        110        120 
VFEPFEEVKK ELMLVPTVPQ VSLARHKYSD QCEAAVNEQI NVEYNVSYVY HGMYAYFDRD 

       130        140        150        160        170        180 
NVALKGLARF FKESSEEERG HAEKLMEYQN KRGGKVKLQS ILMPLSEFDH AEEGDALYAM 

       190        200        210        220        230        240 
ELALSLAKLT NQKLLNLHAV ATRNNDVQLA DFVESKYLRE QVEAIKMISE YVAQLRRVGK 

       250 
GHGVWHFDQM LLQEEEVVA 

« Hide

References

[1]"Occurrence and expression analysis of two types of the tobacco ferritin genes."
Jiang T., Yoshihara T., Masuda T., Goto F.
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY141105 mRNA. Translation: AAN06322.1.

3D structure databases

ProteinModelPortalQ8H1T3.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ8H1T3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRI2_TOBAC
AccessionPrimary (citable) accession number: Q8H1T3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families