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Protein

PTI1-like tyrosine-protein kinase 1

Gene

PTI11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ATPPROSITE-ProRule annotation1
Active sitei200Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 82ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-9020702 Interleukin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
PTI1-like tyrosine-protein kinase 1 (EC:2.7.10.2)
Short name:
PTI1-1
Gene namesi
Name:PTI11
Ordered Locus Names:At1g06700
ORF Names:F12K11.1, F4H5.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G06700
TAIRilocus:2009115 AT1G06700

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004033221 – 361PTI1-like tyrosine-protein kinase 1Add BLAST361

Post-translational modificationi

Autophosphorylated and phosphorylated by OXI1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8H1G6
PRIDEiQ8H1G6

Expressioni

Gene expression databases

ExpressionAtlasiQ8H1G6 baseline and differential
GenevisibleiQ8H1G6 AT

Interactioni

Subunit structurei

Interacts with OXI1.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi22421, 2 interactors
IntActiQ8H1G6, 1 interactor
MINTiQ8H1G6
STRINGi3702.AT1G06700.1

Structurei

3D structure databases

ProteinModelPortaliQ8H1G6
SMRiQ8H1G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 350Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
HOGENOMiHOG000116550
InParanoidiQ8H1G6
KOiK13436
OMAiTCQIEDS
OrthoDBiEOG09360DYR
PhylomeDBiQ8H1G6

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Q8H1G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWICCTCQ IEDSNEEQQL KSSQQQSDAN HKNSKPAPVA KHEVKKEALP
60 70 80 90 100
IEVPPLSLDE VKEKTENFGS KALIGEGSYG RVYYATLNDG VAVALKKLDV
110 120 130 140 150
APEAETDTEF LSQVSMVSRL KHENLIQLLG FCVDGNLRVL AYEFATMGSL
160 170 180 190 200
HDILHGRKGV QGAQPGPTLD WITRVKIAVE AARGLEYLHE KSQPPVIHRD
210 220 230 240 250
IRSSNVLLFE DYKAKIADFN LSNQAPDNAA RLHSTRVLGT FGYHAPEYAM
260 270 280 290 300
TGQLTQKSDV YSFGVVLLEL LTGRKPVDHT MPRGQQSLVT WATPRLSEDK
310 320 330 340 350
VKQCIDPKLK ADYPPKAVAK LAAVAALCVQ YEAEFRPNMS IVVKALQPLL
360
KPPAAAPAPE S
Length:361
Mass (Da):39,820
Last modified:March 1, 2003 - v1
Checksum:i49CD8A555DEF458B
GO

Sequence cautioni

The sequence AAF24808 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF63147 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti343V → A in AAK44075 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007592 Genomic DNA Translation: AAF24808.1 Different initiation.
AC011001 Genomic DNA Translation: AAF63147.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE28025.1
CP002684 Genomic DNA Translation: AEE28026.1
CP002684 Genomic DNA Translation: ANM60512.1
AF370260 mRNA Translation: AAK44075.1
AY150374 mRNA Translation: AAN12919.1
AK317491 mRNA Translation: BAH20156.1
PIRiF86201
RefSeqiNP_001030981.1, NM_001035904.2
NP_001322793.1, NM_001331644.1
NP_172155.1, NM_100547.3
UniGeneiAt.12093

Genome annotation databases

EnsemblPlantsiAT1G06700.1; AT1G06700.1; AT1G06700
AT1G06700.2; AT1G06700.2; AT1G06700
AT1G06700.3; AT1G06700.3; AT1G06700
GeneIDi837180
GrameneiAT1G06700.1; AT1G06700.1; AT1G06700
AT1G06700.2; AT1G06700.2; AT1G06700
AT1G06700.3; AT1G06700.3; AT1G06700
KEGGiath:AT1G06700

Similar proteinsi

Entry informationi

Entry nameiPTI11_ARATH
AccessioniPrimary (citable) accession number: Q8H1G6
Secondary accession number(s): Q94K67, Q9M9X8, Q9SHK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health