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Protein

PTI1-like tyrosine-protein kinase 1

Gene

PTI11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96ATPPROSITE-ProRule annotation1
Active sitei200Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 82ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-450302. activated TAK1 mediates p38 MAPK activation.
R-ATH-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Names & Taxonomyi

Protein namesi
Recommended name:
PTI1-like tyrosine-protein kinase 1 (EC:2.7.10.2)
Short name:
PTI1-1
Gene namesi
Name:PTI11
Ordered Locus Names:At1g06700
ORF Names:F12K11.1, F4H5.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G06700.

Subcellular locationi

GO - Cellular componenti

  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004033221 – 361PTI1-like tyrosine-protein kinase 1Add BLAST361

Post-translational modificationi

Autophosphorylated and phosphorylated by OXI1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8H1G6.
PRIDEiQ8H1G6.

Expressioni

Gene expression databases

GenevisibleiQ8H1G6. AT.

Interactioni

Subunit structurei

Interacts with OXI1.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi22421. 2 interactors.
IntActiQ8H1G6. 1 interactor.
MINTiMINT-8085735.
STRINGi3702.AT1G06700.1.

Structurei

3D structure databases

ProteinModelPortaliQ8H1G6.
SMRiQ8H1G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 350Protein kinasePROSITE-ProRule annotationAdd BLAST283

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116550.
InParanoidiQ8H1G6.
KOiK13436.
OMAiYLHEKSQ.
OrthoDBiEOG09360DYR.
PhylomeDBiQ8H1G6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8H1G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKWICCTCQ IEDSNEEQQL KSSQQQSDAN HKNSKPAPVA KHEVKKEALP
60 70 80 90 100
IEVPPLSLDE VKEKTENFGS KALIGEGSYG RVYYATLNDG VAVALKKLDV
110 120 130 140 150
APEAETDTEF LSQVSMVSRL KHENLIQLLG FCVDGNLRVL AYEFATMGSL
160 170 180 190 200
HDILHGRKGV QGAQPGPTLD WITRVKIAVE AARGLEYLHE KSQPPVIHRD
210 220 230 240 250
IRSSNVLLFE DYKAKIADFN LSNQAPDNAA RLHSTRVLGT FGYHAPEYAM
260 270 280 290 300
TGQLTQKSDV YSFGVVLLEL LTGRKPVDHT MPRGQQSLVT WATPRLSEDK
310 320 330 340 350
VKQCIDPKLK ADYPPKAVAK LAAVAALCVQ YEAEFRPNMS IVVKALQPLL
360
KPPAAAPAPE S
Length:361
Mass (Da):39,820
Last modified:March 1, 2003 - v1
Checksum:i49CD8A555DEF458B
GO

Sequence cautioni

The sequence AAF24808 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAF63147 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti343V → A in AAK44075 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007592 Genomic DNA. Translation: AAF24808.1. Different initiation.
AC011001 Genomic DNA. Translation: AAF63147.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28025.1.
CP002684 Genomic DNA. Translation: AEE28026.1.
AF370260 mRNA. Translation: AAK44075.1.
AY150374 mRNA. Translation: AAN12919.1.
AK317491 mRNA. Translation: BAH20156.1.
PIRiF86201.
RefSeqiNP_001030981.1. NM_001035904.2.
NP_172155.1. NM_100547.3.
UniGeneiAt.12093.

Genome annotation databases

EnsemblPlantsiAT1G06700.1; AT1G06700.1; AT1G06700.
AT1G06700.2; AT1G06700.2; AT1G06700.
GeneIDi837180.
GrameneiAT1G06700.1; AT1G06700.1; AT1G06700.
AT1G06700.2; AT1G06700.2; AT1G06700.
KEGGiath:AT1G06700.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC
Arabidopsis protein tyrosine kinases

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007592 Genomic DNA. Translation: AAF24808.1. Different initiation.
AC011001 Genomic DNA. Translation: AAF63147.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28025.1.
CP002684 Genomic DNA. Translation: AEE28026.1.
AF370260 mRNA. Translation: AAK44075.1.
AY150374 mRNA. Translation: AAN12919.1.
AK317491 mRNA. Translation: BAH20156.1.
PIRiF86201.
RefSeqiNP_001030981.1. NM_001035904.2.
NP_172155.1. NM_100547.3.
UniGeneiAt.12093.

3D structure databases

ProteinModelPortaliQ8H1G6.
SMRiQ8H1G6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi22421. 2 interactors.
IntActiQ8H1G6. 1 interactor.
MINTiMINT-8085735.
STRINGi3702.AT1G06700.1.

Proteomic databases

PaxDbiQ8H1G6.
PRIDEiQ8H1G6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G06700.1; AT1G06700.1; AT1G06700.
AT1G06700.2; AT1G06700.2; AT1G06700.
GeneIDi837180.
GrameneiAT1G06700.1; AT1G06700.1; AT1G06700.
AT1G06700.2; AT1G06700.2; AT1G06700.
KEGGiath:AT1G06700.

Organism-specific databases

TAIRiAT1G06700.

Phylogenomic databases

eggNOGiKOG1187. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000116550.
InParanoidiQ8H1G6.
KOiK13436.
OMAiYLHEKSQ.
OrthoDBiEOG09360DYR.
PhylomeDBiQ8H1G6.

Enzyme and pathway databases

ReactomeiR-ATH-450302. activated TAK1 mediates p38 MAPK activation.
R-ATH-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.

Miscellaneous databases

PROiQ8H1G6.

Gene expression databases

GenevisibleiQ8H1G6. AT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTI11_ARATH
AccessioniPrimary (citable) accession number: Q8H1G6
Secondary accession number(s): Q94K67, Q9M9X8, Q9SHK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.