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Q8H1G6

- PTI11_ARATH

UniProt

Q8H1G6 - PTI11_ARATH

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Protein
PTI1-like tyrosine-protein kinase 1
Gene
PTI11, At1g06700, F12K11.1, F4H5.21
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961ATP By similarity
Active sitei200 – 2001Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 829ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein kinase binding Source: UniProtKB
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G06700-MONOMER.
    ARA:GQT-2033-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PTI1-like tyrosine-protein kinase 1 (EC:2.7.10.2)
    Short name:
    PTI1-1
    Gene namesi
    Name:PTI11
    Ordered Locus Names:At1g06700
    ORF Names:F12K11.1, F4H5.21
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G06700.

    Subcellular locationi

    Cell membrane; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. plasma membrane Source: TAIR
    2. plasmodesma Source: TAIR
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361PTI1-like tyrosine-protein kinase 1
    PRO_0000403322Add
    BLAST

    Post-translational modificationi

    Autophosphorylated and phosphorylated by OXI1.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8H1G6.
    PRIDEiQ8H1G6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8H1G6.

    Interactioni

    Subunit structurei

    Interacts with OXI1.1 Publication

    Protein-protein interaction databases

    BioGridi22421. 2 interactions.
    IntActiQ8H1G6. 1 interaction.
    MINTiMINT-8085735.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8H1G6.
    SMRiQ8H1G6. Positions 15-347.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini68 – 350283Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000116550.
    InParanoidiQ8H1G6.
    OMAiYAVLENG.
    PhylomeDBiQ8H1G6.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8H1G6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKWICCTCQ IEDSNEEQQL KSSQQQSDAN HKNSKPAPVA KHEVKKEALP    50
    IEVPPLSLDE VKEKTENFGS KALIGEGSYG RVYYATLNDG VAVALKKLDV 100
    APEAETDTEF LSQVSMVSRL KHENLIQLLG FCVDGNLRVL AYEFATMGSL 150
    HDILHGRKGV QGAQPGPTLD WITRVKIAVE AARGLEYLHE KSQPPVIHRD 200
    IRSSNVLLFE DYKAKIADFN LSNQAPDNAA RLHSTRVLGT FGYHAPEYAM 250
    TGQLTQKSDV YSFGVVLLEL LTGRKPVDHT MPRGQQSLVT WATPRLSEDK 300
    VKQCIDPKLK ADYPPKAVAK LAAVAALCVQ YEAEFRPNMS IVVKALQPLL 350
    KPPAAAPAPE S 361
    Length:361
    Mass (Da):39,820
    Last modified:March 1, 2003 - v1
    Checksum:i49CD8A555DEF458B
    GO

    Sequence cautioni

    The sequence AAF24808.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAF63147.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti343 – 3431V → A in AAK44075. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007592 Genomic DNA. Translation: AAF24808.1. Different initiation.
    AC011001 Genomic DNA. Translation: AAF63147.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28025.1.
    CP002684 Genomic DNA. Translation: AEE28026.1.
    AF370260 mRNA. Translation: AAK44075.1.
    AY150374 mRNA. Translation: AAN12919.1.
    AK317491 mRNA. Translation: BAH20156.1.
    PIRiF86201.
    RefSeqiNP_001030981.1. NM_001035904.1.
    NP_172155.1. NM_100547.2.
    UniGeneiAt.12093.

    Genome annotation databases

    EnsemblPlantsiAT1G06700.1; AT1G06700.1; AT1G06700.
    AT1G06700.2; AT1G06700.2; AT1G06700.
    GeneIDi837180.
    KEGGiath:AT1G06700.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC
    Arabidopsis protein tyrosine kinases

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC007592 Genomic DNA. Translation: AAF24808.1 . Different initiation.
    AC011001 Genomic DNA. Translation: AAF63147.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE28025.1 .
    CP002684 Genomic DNA. Translation: AEE28026.1 .
    AF370260 mRNA. Translation: AAK44075.1 .
    AY150374 mRNA. Translation: AAN12919.1 .
    AK317491 mRNA. Translation: BAH20156.1 .
    PIRi F86201.
    RefSeqi NP_001030981.1. NM_001035904.1.
    NP_172155.1. NM_100547.2.
    UniGenei At.12093.

    3D structure databases

    ProteinModelPortali Q8H1G6.
    SMRi Q8H1G6. Positions 15-347.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 22421. 2 interactions.
    IntActi Q8H1G6. 1 interaction.
    MINTi MINT-8085735.

    Proteomic databases

    PaxDbi Q8H1G6.
    PRIDEi Q8H1G6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G06700.1 ; AT1G06700.1 ; AT1G06700 .
    AT1G06700.2 ; AT1G06700.2 ; AT1G06700 .
    GeneIDi 837180.
    KEGGi ath:AT1G06700.

    Organism-specific databases

    GeneFarmi 1782. 139.
    TAIRi AT1G06700.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000116550.
    InParanoidi Q8H1G6.
    OMAi YAVLENG.
    PhylomeDBi Q8H1G6.

    Enzyme and pathway databases

    BioCyci ARA:AT1G06700-MONOMER.
    ARA:GQT-2033-MONOMER.

    Gene expression databases

    Genevestigatori Q8H1G6.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
      Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
      DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
      Tissue: Root.
    5. "The Arabidopsis protein kinase PTI1-2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of PDK1 and OXI1."
      Anthony R.G., Khan S., Costa J., Pais M.S., Boegre L.
      J. Biol. Chem. 281:37536-37546(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH OXI1, AUTOPHOSPHORYLATION, PHOSPHORYLATION BY OXI1.
    6. "A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome."
      Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J., Barbier-Brygoo H., Ephritikhine G.
      Mol. Cell. Proteomics 6:1980-1996(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTI11_ARATH
    AccessioniPrimary (citable) accession number: Q8H1G6
    Secondary accession number(s): Q94K67, Q9M9X8, Q9SHK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: March 1, 2003
    Last modified: May 14, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi