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Q8H1G6

- PTI11_ARATH

UniProt

Q8H1G6 - PTI11_ARATH

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Protein

PTI1-like tyrosine-protein kinase 1

Gene

PTI11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei96 – 961ATPPROSITE-ProRule annotation
Active sitei200 – 2001Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi74 – 829ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein kinase binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G06700-MONOMER.
ARA:GQT-2033-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
PTI1-like tyrosine-protein kinase 1 (EC:2.7.10.2)
Short name:
PTI1-1
Gene namesi
Name:PTI11
Ordered Locus Names:At1g06700
ORF Names:F12K11.1, F4H5.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G06700.

Subcellular locationi

Cell membrane 1 Publication; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. plasma membrane Source: TAIR
  2. plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361PTI1-like tyrosine-protein kinase 1PRO_0000403322Add
BLAST

Post-translational modificationi

Autophosphorylated and phosphorylated by OXI1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8H1G6.
PRIDEiQ8H1G6.

Expressioni

Gene expression databases

GenevestigatoriQ8H1G6.

Interactioni

Subunit structurei

Interacts with OXI1.1 Publication

Protein-protein interaction databases

BioGridi22421. 2 interactions.
IntActiQ8H1G6. 1 interaction.
MINTiMINT-8085735.

Structurei

3D structure databases

ProteinModelPortaliQ8H1G6.
SMRiQ8H1G6. Positions 15-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 350283Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116550.
InParanoidiQ8H1G6.
OMAiYAVLENG.
PhylomeDBiQ8H1G6.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8H1G6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKWICCTCQ IEDSNEEQQL KSSQQQSDAN HKNSKPAPVA KHEVKKEALP
60 70 80 90 100
IEVPPLSLDE VKEKTENFGS KALIGEGSYG RVYYATLNDG VAVALKKLDV
110 120 130 140 150
APEAETDTEF LSQVSMVSRL KHENLIQLLG FCVDGNLRVL AYEFATMGSL
160 170 180 190 200
HDILHGRKGV QGAQPGPTLD WITRVKIAVE AARGLEYLHE KSQPPVIHRD
210 220 230 240 250
IRSSNVLLFE DYKAKIADFN LSNQAPDNAA RLHSTRVLGT FGYHAPEYAM
260 270 280 290 300
TGQLTQKSDV YSFGVVLLEL LTGRKPVDHT MPRGQQSLVT WATPRLSEDK
310 320 330 340 350
VKQCIDPKLK ADYPPKAVAK LAAVAALCVQ YEAEFRPNMS IVVKALQPLL
360
KPPAAAPAPE S
Length:361
Mass (Da):39,820
Last modified:March 1, 2003 - v1
Checksum:i49CD8A555DEF458B
GO

Sequence cautioni

The sequence AAF24808.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAF63147.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431V → A in AAK44075. (PubMed:14593172)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007592 Genomic DNA. Translation: AAF24808.1. Different initiation.
AC011001 Genomic DNA. Translation: AAF63147.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE28025.1.
CP002684 Genomic DNA. Translation: AEE28026.1.
AF370260 mRNA. Translation: AAK44075.1.
AY150374 mRNA. Translation: AAN12919.1.
AK317491 mRNA. Translation: BAH20156.1.
PIRiF86201.
RefSeqiNP_001030981.1. NM_001035904.1.
NP_172155.1. NM_100547.2.
UniGeneiAt.12093.

Genome annotation databases

EnsemblPlantsiAT1G06700.1; AT1G06700.1; AT1G06700.
AT1G06700.2; AT1G06700.2; AT1G06700.
GeneIDi837180.
KEGGiath:AT1G06700.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC
Arabidopsis protein tyrosine kinases

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC007592 Genomic DNA. Translation: AAF24808.1 . Different initiation.
AC011001 Genomic DNA. Translation: AAF63147.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE28025.1 .
CP002684 Genomic DNA. Translation: AEE28026.1 .
AF370260 mRNA. Translation: AAK44075.1 .
AY150374 mRNA. Translation: AAN12919.1 .
AK317491 mRNA. Translation: BAH20156.1 .
PIRi F86201.
RefSeqi NP_001030981.1. NM_001035904.1.
NP_172155.1. NM_100547.2.
UniGenei At.12093.

3D structure databases

ProteinModelPortali Q8H1G6.
SMRi Q8H1G6. Positions 15-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 22421. 2 interactions.
IntActi Q8H1G6. 1 interaction.
MINTi MINT-8085735.

Proteomic databases

PaxDbi Q8H1G6.
PRIDEi Q8H1G6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G06700.1 ; AT1G06700.1 ; AT1G06700 .
AT1G06700.2 ; AT1G06700.2 ; AT1G06700 .
GeneIDi 837180.
KEGGi ath:AT1G06700.

Organism-specific databases

GeneFarmi 1782. 139.
TAIRi AT1G06700.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000116550.
InParanoidi Q8H1G6.
OMAi YAVLENG.
PhylomeDBi Q8H1G6.

Enzyme and pathway databases

BioCyci ARA:AT1G06700-MONOMER.
ARA:GQT-2033-MONOMER.

Gene expression databases

Genevestigatori Q8H1G6.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Analysis of multiple occurrences of alternative splicing events in Arabidopsis thaliana using novel sequenced full-length cDNAs."
    Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M., Shinozaki K.
    DNA Res. 16:155-164(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
    Tissue: Root.
  5. "The Arabidopsis protein kinase PTI1-2 is activated by convergent phosphatidic acid and oxidative stress signaling pathways downstream of PDK1 and OXI1."
    Anthony R.G., Khan S., Costa J., Pais M.S., Boegre L.
    J. Biol. Chem. 281:37536-37546(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OXI1, AUTOPHOSPHORYLATION, PHOSPHORYLATION BY OXI1.
  6. "A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome."
    Marmagne A., Ferro M., Meinnel T., Bruley C., Kuhn L., Garin J., Barbier-Brygoo H., Ephritikhine G.
    Mol. Cell. Proteomics 6:1980-1996(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTI11_ARATH
AccessioniPrimary (citable) accession number: Q8H1G6
Secondary accession number(s): Q94K67, Q9M9X8, Q9SHK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3