GTP-binding nuclear protein Ran-3 - Arabidopsis thaliana (Mouse-ear cress)

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Q8H156 (RAN3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
GTP-binding nuclear protein Ran-3

Alternative name(s):
Ras-related nuclear protein 3

Gene names

Name:	RAN3
Ordered Locus Names:	At5g55190
ORF Names:	MCO15.14

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity.
Subunit structure	Interacts with RanBP1a and RanBP1b. Ref.1
Subcellular location	Nucleus By similarity.
Induction	Induced by salt treatment. Regulated by light. Ref.8
Sequence similarities	Belongs to the small GTPase superfamily. Ran family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein import into nucleus Traceable author statement Ref.1. Source: TAIR small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from direct assay PubMed 22430844. Source: TAIR nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasmodesma Inferred from direct assay PubMed 21533090. Source: TAIR
Molecular_function	GTP binding Inferred from sequence or structural similarity Ref.1. Source: TAIR GTPase activity Inferred from sequence or structural similarity Ref.1. Source: TAIR
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 221

221

GTP-binding nuclear protein Ran-3

PRO_0000208719

Regions

Nucleotide binding

20 – 27

GTP By similarity

Nucleotide binding

68 – 72

GTP By similarity

Nucleotide binding

125 – 128

GTP By similarity

Experimental info

Sequence conflict

F → P in CAA66049. Ref.1

Sequence conflict

L → P in AAC34900. Ref.3

Sequence conflict

L → P in AAB97312. Ref.3

Sequence conflict

D → E in AAN31865. Ref.6

Sequence conflict

102

K → R in AAC34900. Ref.3

Sequence conflict

102

K → R in AAB97312. Ref.3

Sequence conflict

145 – 146

KN → EE in AAC34900. Ref.3

Sequence conflict

145 – 146

KN → EE in AAB97312. Ref.3

Sequence conflict

199

Q → R in CAA66049. Ref.1

Sequence conflict

203 – 204

EL → DV in CAA66049. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q8H156 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: 96648D02606EDC0B
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FASTA

221

25,080

        10         20         30         40         50         60 
MALPNQQTVD YPSFKLVIVG DGGTGKTTFV KRHLTGEFEK KYEPTIGVEV HPLDFFTNCG 

        70         80         90        100        110        120 
KIRFYCWDTA GQEKFGGLRD GYYIHGQCAI IMFDVTARLT YKNVPTWHRD LCRVCENIPI 

       130        140        150        160        170        180 
VLCGNKVDVK NRQVKAKQVT FHRKKNLQYY EISAKSNYNF EKPFLYLARK LAGDANLHFV 

       190        200        210        220 
ESPALAPPEV QIDLAAQQQH EAELAAAASQ PLPDDDDDTF E

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of proteins that interact with the GTP-bound form of the regulatory GTPase Ran in Arabidopsis." Haizel T., Merkle T., Pay A., Fejes E., Nagy F. Plant J. 11:93-103(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RANBP1A AND RANBP1B.
[2]	"A new member of the Ran-GTPases in Arabidopsis thaliana." Bischoff F., Palme K. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[3]	"Isolation of salt stress inducible Ran1 isoform." Pih K.T., Park J.M., Jang H.J., Kang S.G., Piao H.L., Hwang I.H. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[4]	"Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones." Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S. DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[5]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[6]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[7]	"Analysis of the small GTPase gene superfamily of Arabidopsis." Vernoud V., Horton A.C., Yang Z., Nielsen E. Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[8]	"Phytochrome-mediated differential gene expression of plant Ran/TC4 small G-proteins." Lee Y., Kim M.-H., Kim S.-K., Kim S.-H. Planta 228:215-224(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X97381 mRNA. Translation: CAA66049.1. U73810 mRNA. Translation: AAB58478.1. U75601 mRNA. Translation: AAC34900.1. AF017991 mRNA. Translation: AAB97312.1. AB010071 Genomic DNA. Translation: BAB08588.1. CP002688 Genomic DNA. Translation: AED96598.1. AY042796 mRNA. Translation: AAK68736.1. AY050317 mRNA. Translation: AAK91334.1. AY116939 mRNA. Translation: AAM51573.1. BT000723 mRNA. Translation: AAN31865.1.
IPI	IPI00547198.
RefSeq	NP_200330.1. NM_124901.4.
UniGene	At.20354.
3D structure databases
ProteinModelPortal	Q8H156.
SMR	Q8H156. Positions 14-218.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8H156. 3 interactions.
STRING	3702.AT5G55190.1-P.
Proteomic databases
PaxDb	Q8H156.
PRIDE	Q8H156.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT5G55190.1; AT5G55190.1; AT5G55190.
GeneID	835612.
KEGG	ath:AT5G55190.
Organism-specific databases
GeneFarm	5098.
TAIR	At5g55190.
Phylogenomic databases
eggNOG	COG1100.
HOGENOM	HOG000216664.
InParanoid	Q8H156.
KO	K07936.
OMA	DANLHFV.
PhylomeDB	Q8H156.
ProtClustDB	PLN03071.
Gene expression databases
ArrayExpress	Q8H156.
Genevestigator	Q8H156.
GermOnline	AT5G55190. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002041. Ran_GTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00627. GTPRANTC4.
SMART	SM00176. RAN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51418. RAN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RAN3_ARATH

Accession

Primary (citable) accession number: Q8H156
Secondary accession number(s): O04148, O04664, O22495

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	September 27, 2005
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents