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Protein

Histone deacetylase 9

Gene

HDA9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei137By similarity1

GO - Molecular functioni

GO - Biological processi

  • histone H3-K9 deacetylation Source: TAIR
  • negative regulation of seed germination Source: TAIR
  • regulation of leaf senescence Source: TAIR
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 9 (EC:3.5.1.98)
Gene namesi
Name:HDA9
Ordered Locus Names:At3g44680
ORF Names:T18B22.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G44680
TAIRilocus:2098115 AT3G44680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800881 – 426Histone deacetylase 9Add BLAST426

Proteomic databases

PaxDbiQ8H0W2

Expressioni

Gene expression databases

ExpressionAtlasiQ8H0W2 baseline and differential
GenevisibleiQ8H0W2 AT

Interactioni

Subunit structurei

Interacts with AHL22.1 Publication

Protein-protein interaction databases

BioGridi8914, 5 interactors
STRINGi3702.AT3G44680.1

Structurei

3D structure databases

ProteinModelPortaliQ8H0W2
SMRiQ8H0W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 318Histone deacetylaseAdd BLAST313

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi296 – 299Poly-Gly4
Compositional biasi384 – 424Asp-richAdd BLAST41

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
HOGENOMiHOG000225180
InParanoidiQ8H0W2
KOiK06067
OMAiPRAWTHL
OrthoDBiEOG093609CH
PhylomeDBiQ8H0W2

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q8H0W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSKDKISYF YDGDVGSVYF GPNHPMKPHR LCMTHHLILA YGLHSKMEVY
60 70 80 90 100
RPHKAYPIEM AQFHSPDYVE FLQRINPENQ NLFPNEMARY NLGEDCPVFE
110 120 130 140 150
DLFEFCQLYA GGTIDAARRL NNKLCDIAIN WAGGLHHAKK CDASGFCYIN
160 170 180 190 200
DLVLGILELL KHHPRVLYID IDVHHGDGVE EAFYFTDRVM TVSFHKFGDK
210 220 230 240 250
FFPGTGDVKE IGEREGKFYA INVPLKDGID DSSFNRLFRT IISKVVEIYQ
260 270 280 290 300
PGAIVLQCGA DSLARDRLGC FNLSIDGHAE CVKFVKKFNL PLLVTGGGGY
310 320 330 340 350
TKENVARCWT VETGILLDTE LPNEIPENDY IKYFAPDFSL KIPGGHIENL
360 370 380 390 400
NTKSYISSIK VQILENLRYI QHAPSVQMQE VPPDFYIPDF DEDEQNPDVR
410 420
ADQRSRDKQI QRDDEYFDGD NDNDAS
Length:426
Mass (Da):48,688
Last modified:March 1, 2003 - v1
Checksum:iB7B4B9D7432C6DBD
GO

Sequence cautioni

The sequence CAB72470 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138652 Genomic DNA Translation: CAB72470.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE77930.1
BT002003 mRNA Translation: AAN72014.1
BT006576 mRNA Translation: AAP31920.1
PIRiT47443
RefSeqiNP_190054.2, NM_114336.4
UniGeneiAt.36124

Genome annotation databases

EnsemblPlantsiAT3G44680.1; AT3G44680.1; AT3G44680
GeneIDi823594
GrameneiAT3G44680.1; AT3G44680.1; AT3G44680
KEGGiath:AT3G44680

Similar proteinsi

Entry informationi

Entry nameiHDA9_ARATH
AccessioniPrimary (citable) accession number: Q8H0W2
Secondary accession number(s): Q9M1N6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health