ID   LOX6_ORYSJ              Reviewed;         918 AA.
AC   Q8H016; Q8H7L4;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   07-JUL-2009, entry version 44.
DE   RecName: Full=Probable lipoxygenase 6;
DE            EC=1.13.11.12;
GN   OrderedLocusNames=Os03g0179900, LOC_Os03g08220;
GN   ORFNames=OSJNBa0050H14.14, OSJNBb0076N15.1;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Ehrhartoideae; Oryzeae; Oryza.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R.,
RA   Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L.,
RA   Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S., Johri S.,
RA   Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S.,
RA   Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J.,
RA   de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H.,
RA   Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F.,
RA   Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A.,
RA   Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J.,
RA   Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L.,
RA   Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A.,
RA   Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W.,
RA   Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome
RT   3 and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   MEDLINE=22752273; PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Plant lipoxygenase may be involved in a number of
CC       diverse aspects of plant physiology including growth and
CC       development, pest resistance, and senescence or responses to
CC       wounding. Catalyzes the hydroperoxidation of lipids, containing a
CC       cis,cis-1,4-pentadiene structure (By similarity).
CC   -!- CATALYTIC ACTIVITY: Linoleate + O(2) = (9Z,11E)-(13S)-13-
CC       hydroperoxyoctadeca-9,11-dienoate.
CC   -!- COFACTOR: Binds 1 iron ion per subunit. Iron is tightly bound (By
CC       similarity).
CC   -!- PATHWAY: Lipid metabolism; oxylipin biosynthesis.
CC   -!- SIMILARITY: Belongs to the lipoxygenase family.
CC   -!- SIMILARITY: Contains 1 lipoxygenase domain.
CC   -!- SIMILARITY: Contains 1 PLAT domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN65431.1; Type=Erroneous gene model prediction;
CC       Sequence=AAO13474.1; Type=Erroneous gene model prediction;
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DR   EMBL; AC125472; AAO13474.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC126223; AAN65431.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AK121637; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001049158.1; -.
DR   UniGene; Os.9616; -.
DR   HSSP; P08170; 2SBL.
DR   GeneID; 4331824; -.
DR   KEGG; osa:4331824; -.
DR   Gramene; Q8H016; -.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016165; F:lipoxygenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0031408; P:oxylipin biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000907; LipOase.
DR   InterPro; IPR013819; LipOase_C.
DR   InterPro; IPR001024; LipOase_LH2.
DR   InterPro; IPR001246; LipOase_pln.
DR   Gene3D; G3DSA:2.60.60.20; Lipase_LipOase; 1.
DR   PANTHER; PTHR11771; LipOase; 1.
DR   Pfam; PF00305; Lipoxygenase; 1.
DR   Pfam; PF01477; PLAT; 1.
DR   PRINTS; PR00087; LIPOXYGENASE.
DR   PRINTS; PR00468; PLTLPOXGNASE.
DR   SMART; SM00308; LH2; 1.
DR   PROSITE; PS00711; LIPOXYGENASE_1; 1.
DR   PROSITE; PS00081; LIPOXYGENASE_2; 1.
DR   PROSITE; PS51393; LIPOXYGENASE_3; 1.
DR   PROSITE; PS50095; PLAT; 1.
PE   2: Evidence at transcript level;
KW   Dioxygenase; Fatty acid biosynthesis; Iron; Lipid synthesis;
KW   Metal-binding; Oxidoreductase; Oxylipin biosynthesis.
FT   CHAIN         1    918       Probable lipoxygenase 6.
FT                                /FTId=PRO_0000220712.
FT   DOMAIN       90    218       PLAT.
FT   DOMAIN      221    918       Lipoxygenase.
FT   METAL       573    573       Iron; catalytic (By similarity).
FT   METAL       578    578       Iron; catalytic (By similarity).
FT   METAL       765    765       Iron; catalytic (By similarity).
FT   METAL       769    769       Iron; catalytic (By similarity).
FT   METAL       918    918       Iron; via carboxylate; catalytic (By
FT                                similarity).
SQ   SEQUENCE   918 AA;  101959 MW;  25BB8DD1E7906CF8 CRC64;
     MELTGLTRAA AAATVTPPAP RRGWGELRFA PLLPGERHGR RKVVVAAISE EVPRLAASPS
     SGIKGGGAGE RRPAPEKVAL RAALTVRRKQ KEDIKEAVAG HLDALWDMVG RNVVLELIST
     KIHPRTKKPM QSGRVSIKDW CQKRGAKGDH VVYTAEFTVD ADFGEPGAIA VANRHNREFF
     LESIVVEGGG LPCGPVHFAC NSWVQSTREL PTKRVFFSNK PYLPSETPPG LRELREKELK
     DLRGDGTGVR KLSDRIYDYA TYNDLGNPDK GKEFIRPILG GEKIPYPRRC RTGRPPTDTN
     MLAESRVEKP HPIYVPRDEA FEELKQGAFS SGRLRAVLHT LIPSLIASIS AETHNFQGFH
     HIDNLYKEGL RLKLGLQEHL FQKIPLVQKI QESSEGMLRY DTPSILSKDK FAWLRDDEFA
     RQAVAGINPV NIERLQVFPP VSKLDPAIYG PPESSITETH IAGHLNGLTV QQAMDEAKLF
     IVDYHDAYLP FLDRINAIDG RKAYATRTIF FLTEAGTLKP IAIELSLPPA KPGEPRPSKV
     LTPPYDATSN WLWMLAKAHV SSNDAGVHQL VNHWLRTHAT MEPFILAAHR HMSAMHPIFK
     LLHPHMRYTL EINALARQSL INADGVIESC FTPGPVSGEI SAAYYRNHWR FDLEGLPSDL
     IRRGVAVEDA TQPHGVRLLI EDYPYANDGL LLWSAIRSWV ESYVQLYYPD AGTVQCDLEL
     QGWYHESIHV GHGDLRHAPW WPPLSTPVDL ASILTTLVWL ASAQHAALNF GQYPLGGYVP
     NRPPLIRRLL PDLERDAAEY AAFLADPHRF FLNAMPGVLE ATKFMAVVDT LSTHSPDEEY
     LGEGRDEGGV PWTADEAAVA AHGMFAADVR RAEETIERRN ADHGRKNRCG AGVLPYELLA
     PSSPPGVTCR GVPNSISI
//