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Q8H016

- LOX6_ORYSJ

UniProt

Q8H016 - LOX6_ORYSJ

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Protein

Probable lipoxygenase 6

Gene

Os03g0179900

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity).By similarity

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi573 – 5731Iron; catalyticPROSITE-ProRule annotation
Metal bindingi578 – 5781Iron; catalyticPROSITE-ProRule annotation
Metal bindingi765 – 7651Iron; catalyticPROSITE-ProRule annotation
Metal bindingi769 – 7691Iron; catalyticPROSITE-ProRule annotation
Metal bindingi918 – 9181Iron; via carboxylate; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. oxylipin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_220543. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_245113. Synthesis of 12-eicosatetraenoic acid derivatives.
REACT_254799. Synthesis of Hepoxilins (HX) and Trioxilins (TrX).
REACT_256153. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_261475. Synthesis of Lipoxins (LX).
UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipoxygenase 6 (EC:1.13.11.12)
Gene namesi
Ordered Locus Names:Os03g0179900, LOC_Os03g08220
ORF Names:OSJNBa0050H14.14, OSJNBb0076N15.1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiQ8H016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 918918Probable lipoxygenase 6PRO_0000220712Add
BLAST

Proteomic databases

PRIDEiQ8H016.

Expressioni

Gene expression databases

ExpressionAtlasiQ8H016. baseline.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 218129PLATPROSITE-ProRule annotationAdd
BLAST
Domaini221 – 918698LipoxygenasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated
Contains 1 lipoxygenase domain.PROSITE-ProRule annotation
Contains 1 PLAT domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG69653.
HOGENOMiHOG000230469.
InParanoidiQ8H016.
KOiK00454.
OMAiLSKDKFA.

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8H016-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELTGLTRAA AAATVTPPAP RRGWGELRFA PLLPGERHGR RKVVVAAISE
60 70 80 90 100
EVPRLAASPS SGIKGGGAGE RRPAPEKVAL RAALTVRRKQ KEDIKEAVAG
110 120 130 140 150
HLDALWDMVG RNVVLELIST KIHPRTKKPM QSGRVSIKDW CQKRGAKGDH
160 170 180 190 200
VVYTAEFTVD ADFGEPGAIA VANRHNREFF LESIVVEGGG LPCGPVHFAC
210 220 230 240 250
NSWVQSTREL PTKRVFFSNK PYLPSETPPG LRELREKELK DLRGDGTGVR
260 270 280 290 300
KLSDRIYDYA TYNDLGNPDK GKEFIRPILG GEKIPYPRRC RTGRPPTDTN
310 320 330 340 350
MLAESRVEKP HPIYVPRDEA FEELKQGAFS SGRLRAVLHT LIPSLIASIS
360 370 380 390 400
AETHNFQGFH HIDNLYKEGL RLKLGLQEHL FQKIPLVQKI QESSEGMLRY
410 420 430 440 450
DTPSILSKDK FAWLRDDEFA RQAVAGINPV NIERLQVFPP VSKLDPAIYG
460 470 480 490 500
PPESSITETH IAGHLNGLTV QQAMDEAKLF IVDYHDAYLP FLDRINAIDG
510 520 530 540 550
RKAYATRTIF FLTEAGTLKP IAIELSLPPA KPGEPRPSKV LTPPYDATSN
560 570 580 590 600
WLWMLAKAHV SSNDAGVHQL VNHWLRTHAT MEPFILAAHR HMSAMHPIFK
610 620 630 640 650
LLHPHMRYTL EINALARQSL INADGVIESC FTPGPVSGEI SAAYYRNHWR
660 670 680 690 700
FDLEGLPSDL IRRGVAVEDA TQPHGVRLLI EDYPYANDGL LLWSAIRSWV
710 720 730 740 750
ESYVQLYYPD AGTVQCDLEL QGWYHESIHV GHGDLRHAPW WPPLSTPVDL
760 770 780 790 800
ASILTTLVWL ASAQHAALNF GQYPLGGYVP NRPPLIRRLL PDLERDAAEY
810 820 830 840 850
AAFLADPHRF FLNAMPGVLE ATKFMAVVDT LSTHSPDEEY LGEGRDEGGV
860 870 880 890 900
PWTADEAAVA AHGMFAADVR RAEETIERRN ADHGRKNRCG AGVLPYELLA
910
PSSPPGVTCR GVPNSISI
Length:918
Mass (Da):101,959
Last modified:August 30, 2005 - v2
Checksum:i25BB8DD1E7906CF8
GO

Sequence cautioni

The sequence AAN65431.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAO13474.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125472 Genomic DNA. Translation: AAO13474.1. Sequence problems.
AC126223 Genomic DNA. Translation: AAN65431.1. Sequence problems.
AK121637 mRNA. No translation available.
RefSeqiNP_001049158.1. NM_001055693.1.
UniGeneiOs.9616.

Genome annotation databases

EnsemblPlantsiOS03T0179900-01; OS03T0179900-01; OS03G0179900.
GeneIDi4331824.
KEGGiosa:4331824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125472 Genomic DNA. Translation: AAO13474.1 . Sequence problems.
AC126223 Genomic DNA. Translation: AAN65431.1 . Sequence problems.
AK121637 mRNA. No translation available.
RefSeqi NP_001049158.1. NM_001055693.1.
UniGenei Os.9616.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8H016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS03T0179900-01 ; OS03T0179900-01 ; OS03G0179900 .
GeneIDi 4331824.
KEGGi osa:4331824.

Organism-specific databases

Gramenei Q8H016.

Phylogenomic databases

eggNOGi NOG69653.
HOGENOMi HOG000230469.
InParanoidi Q8H016.
KOi K00454.
OMAi LSKDKFA.

Enzyme and pathway databases

UniPathwayi UPA00382 .
Reactomei REACT_220543. Synthesis of Leukotrienes (LT) and Eoxins (EX).
REACT_245113. Synthesis of 12-eicosatetraenoic acid derivatives.
REACT_254799. Synthesis of Hepoxilins (HX) and Trioxilins (TrX).
REACT_256153. Synthesis of 15-eicosatetraenoic acid derivatives.
REACT_261475. Synthesis of Lipoxins (LX).

Gene expression databases

ExpressionAtlasi Q8H016. baseline.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiLOX6_ORYSJ
AccessioniPrimary (citable) accession number: Q8H016
Secondary accession number(s): Q8H7L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 26, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3