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Protein

Probable lipoxygenase 6

Gene

Os03g0179900

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity).By similarity

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi: oxylipin biosynthesis

This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi573Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi578Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi765Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi769Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi918Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-OSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX)
R-OSA-2142696 Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
R-OSA-2142700 Synthesis of Lipoxins (LX)
R-OSA-2142712 Synthesis of 12-eicosatetraenoic acid derivatives
R-OSA-2142770 Synthesis of 15-eicosatetraenoic acid derivatives
R-OSA-6798695 Neutrophil degranulation
UniPathwayiUPA00382

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipoxygenase 6 (EC:1.13.11.12)
Gene namesi
Ordered Locus Names:Os03g0179900Imported, LOC_Os03g08220Imported
ORF Names:OSJNBa0050H14.14, OSJNBb0076N15.1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002207121 – 918Probable lipoxygenase 6Add BLAST918

Proteomic databases

PaxDbiQ8H016

Expressioni

Gene expression databases

ExpressionAtlasiQ8H016 baseline and differential
GenevisibleiQ8H016 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g08220.1

Structurei

3D structure databases

SMRiQ8H016
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 218PLATPROSITE-ProRule annotationAdd BLAST129
Domaini221 – 918LipoxygenasePROSITE-ProRule annotationAdd BLAST698

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

eggNOGiENOG410IEKP Eukaryota
ENOG410YN4N LUCA
HOGENOMiHOG000230469
InParanoidiQ8H016
KOiK00454
OMAiWPSLSTP
OrthoDBiEOG0936038B

Family and domain databases

Gene3Di4.10.372.10, 1 hit
InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR027433 Lipoxygenase_dom_3
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8H016-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTGLTRAA AAATVTPPAP RRGWGELRFA PLLPGERHGR RKVVVAAISE
60 70 80 90 100
EVPRLAASPS SGIKGGGAGE RRPAPEKVAL RAALTVRRKQ KEDIKEAVAG
110 120 130 140 150
HLDALWDMVG RNVVLELIST KIHPRTKKPM QSGRVSIKDW CQKRGAKGDH
160 170 180 190 200
VVYTAEFTVD ADFGEPGAIA VANRHNREFF LESIVVEGGG LPCGPVHFAC
210 220 230 240 250
NSWVQSTREL PTKRVFFSNK PYLPSETPPG LRELREKELK DLRGDGTGVR
260 270 280 290 300
KLSDRIYDYA TYNDLGNPDK GKEFIRPILG GEKIPYPRRC RTGRPPTDTN
310 320 330 340 350
MLAESRVEKP HPIYVPRDEA FEELKQGAFS SGRLRAVLHT LIPSLIASIS
360 370 380 390 400
AETHNFQGFH HIDNLYKEGL RLKLGLQEHL FQKIPLVQKI QESSEGMLRY
410 420 430 440 450
DTPSILSKDK FAWLRDDEFA RQAVAGINPV NIERLQVFPP VSKLDPAIYG
460 470 480 490 500
PPESSITETH IAGHLNGLTV QQAMDEAKLF IVDYHDAYLP FLDRINAIDG
510 520 530 540 550
RKAYATRTIF FLTEAGTLKP IAIELSLPPA KPGEPRPSKV LTPPYDATSN
560 570 580 590 600
WLWMLAKAHV SSNDAGVHQL VNHWLRTHAT MEPFILAAHR HMSAMHPIFK
610 620 630 640 650
LLHPHMRYTL EINALARQSL INADGVIESC FTPGPVSGEI SAAYYRNHWR
660 670 680 690 700
FDLEGLPSDL IRRGVAVEDA TQPHGVRLLI EDYPYANDGL LLWSAIRSWV
710 720 730 740 750
ESYVQLYYPD AGTVQCDLEL QGWYHESIHV GHGDLRHAPW WPPLSTPVDL
760 770 780 790 800
ASILTTLVWL ASAQHAALNF GQYPLGGYVP NRPPLIRRLL PDLERDAAEY
810 820 830 840 850
AAFLADPHRF FLNAMPGVLE ATKFMAVVDT LSTHSPDEEY LGEGRDEGGV
860 870 880 890 900
PWTADEAAVA AHGMFAADVR RAEETIERRN ADHGRKNRCG AGVLPYELLA
910
PSSPPGVTCR GVPNSISI
Length:918
Mass (Da):101,959
Last modified:August 30, 2005 - v2
Checksum:i25BB8DD1E7906CF8
GO

Sequence cautioni

The sequence AAN65431 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAO13474 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125472 Genomic DNA Translation: AAO13474.1 Sequence problems.
AC126223 Genomic DNA Translation: AAN65431.1 Sequence problems.
DP000009 Genomic DNA Translation: ABF94297.1
AP008209 Genomic DNA Translation: BAF11072.1
AP014959 Genomic DNA Translation: BAS82610.1
AK121637 mRNA No translation available.
RefSeqiXP_015630875.1, XM_015775389.1
UniGeneiOs.9616

Genome annotation databases

EnsemblPlantsiOs03t0179900-01; Os03t0179900-01; Os03g0179900
GeneIDi4331824
GrameneiOs03t0179900-01; Os03t0179900-01; Os03g0179900
KEGGiosa:4331824

Similar proteinsi

Entry informationi

Entry nameiLOX6_ORYSJ
AccessioniPrimary (citable) accession number: Q8H016
Secondary accession number(s): A0A0P0VTS2, Q10QX5, Q8H7L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: March 28, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health