Reviewed, UniProtKB/Swiss-Prot Q8GZ42 (ATX5_ARATH)

Names and origin

Protein names

Recommended name:
    Histone-lysine N-methyltransferase ATX5
    EC=2.1.1.43
Alternative name(s):
    Trithorax-homolog protein 5
      Short name=TRX-homolog protein 5
    Protein SET DOMAIN GROUP 29

Gene names

Name:	ATX5
Synonyms:	SDG29, SET29
Ordered Locus Names:	At5g53430
ORF Names:	MYN8.4

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	1043 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Histone methyltransferase By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 2 PHD-type zinc fingers. Contains 1 post-SET domain. Contains 1 PWWP domain. Contains 1 SET domain.
Sequence caution	The sequence BAA97320.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	Metal-binding S-adenosyl-L-methionine Zinc
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA mediated transformation Inferred from mutant phenotype. Source: TAIR chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1043	1043	Histone-lysine N-methyltransferase ATX5		PRO_0000233358
Regions
	Domain	223 – 292	70	PWWP
	Domain	899 – 1022	124	SET
	Domain	1027 – 1043	17	Post-SET
	Zinc finger	413 – 469	57	PHD-type 1
	Zinc finger	607 – 658	52	PHD-type 2

Sequences

	Sequence		Length	Mass (Da)
	Q8GZ42-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 0871B150AA379250	FASTA	1,043	119,122
	10 20 30 40 50 60 MIIKRKLKTL KRCNSTNEED DIVRKKRKVN LNGGGSGGDY YYPLNLLGEI GAGIVPGKNG 70 80 90 100 110 120 FSVSLCKQVS CSPKVEVVEE EEEEEEIKST RLVSRPPLVK TSRGRVQVLP SRFNDSVIEN 130 140 150 160 170 180 WRKDNKSSGE EREEEIEEEA CRKEKVKVSS NHSLKIKQQE TKFTPRNYKY SSSSALCGEI 190 200 210 220 230 240 DDEDKCEEIV RYGNSFEMKK QRYVDDEPRP KKEGVYGPED FYSGDLVWGK SGRNEPFWPA 250 260 270 280 290 300 IVIDPMTQAP ELVLRSCIPD AACVMFFGHS GTENERDYAW VRRGMIFPFV DYVERLQEQS 310 320 330 340 350 360 ELRGCNPRDF QMALEEALLA DQGFTEKLMQ DIHMAAGNQT FDDSVYRWVE EAAGSSQYLD 370 380 390 400 410 420 HVAPSQDMKK YRNPRACVGC GMVLSFKMAQ KMKALIPGDQ LLCQPCSKLT KPKHVCGICK 430 440 450 460 470 480 RIWNHLDSQS WVRCDGCKVW IHSACDQISH KHFKDLGETD YYCPTCRTKF DFELSDSEKP 490 500 510 520 530 540 DSKSKLGKNN APMVLPDKVI VVCSGVEGIY FPSLHLVVCK CGSCGPERKA LSEWERHTGS 550 560 570 580 590 600 KAKNWRTSVK VKSSKLPLEE WMMKLAEFHA NATAAKPPKR PSIKQRKQRL LSFLREKYEP 610 620 630 640 650 660 VNVKWTTERC AVCRWVEDWD YNKIIICNRC QIAVHQECYG TRNVRDFTSW VCKACETPEI 670 680 690 700 710 720 KRECCLCPVK GGALKPTDVE TLWVHVTCAW FQPEVCFASE EKMEPALGIL SIPSSNFVKI 730 740 750 760 770 780 CVICKQIHGS CTQCCKCSTY YHAMCASRAG YRMELHCLEK NGRQITKMVS YCSYHRAPNP 790 800 810 820 830 840 DTVLIIQTPS GVFSAKSLVQ NKKKSGTRLI LANREEIEES AAEDTIPIDP FSSARCRLYK 850 860 870 880 890 900 RTVNSKKRTK EEGIPHYTGG LRHHPSAAIQ TLNAFRHVAE EPKSFSSFRE RLHHLQRTEM 910 920 930 940 950 960 ERVCFGRSGI HGWGLFARRN IQEGEMVLEY RGEQVRGIIA DLREARYRRE GKDCYLFKIS 970 980 990 1000 1010 1020 EEVVVDATEK GNIARLINHS CMPNCYARIM SVGDDESRIV LIAKTTVASC EELTYDYLFD 1030 1040 PDEPDEFKVP CLCKSPNCRK FMN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S. DNA Res. 7:31-63(2000) [PubMed: 10718197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 637-865, NOMENCLATURE.
+	Additional computationally mapped references.

Web resources

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB020754 Genomic DNA. Translation: BAA97320.1. Sequence problems. AK117221 mRNA. Translation: BAC41897.1. BT005981 mRNA. Translation: AAO64916.1. AY049755 mRNA. Translation: AAL12216.1.
IPI	IPI00547022.
RefSeq	NP_200155.2.
UniGene	At.46146
3D structure databases
HSSP	HSSP built from PDB template 1PEG based on UniProtKB Q8X225.
ModBase	Search...
Genome annotation databases
GeneID	835424.
GenomeReviews	Gene locus AT5G53430 in contig BA000015_GR.
KEGG	ath:AT5G53430.
NMPDR	fig|3702.1.peg.27237.
Organism-specific databases
TAIR	At5g53430.
Enzyme and pathway databases
BRENDA	2.1.1.43. 302.
Gene expression databases
Genevestigator	Q8GZ42.
GermOnline	AT5G53430. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR003616. Post-SET_Zn_bd. IPR000313. PWWP. IPR001214. SET. IPR019786. Zinc_finger_PHD-type_CS. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view]
Pfam	PF00628. PHD. 2 hits. PF00855. PWWP. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00249. PHD. 3 hits. SM00508. PostSET. 1 hit. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50868. POST_SET. 1 hit. PS50812. PWWP. 1 hit. PS50280. SET. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATX5_ARATH

Accession

Primary (citable) accession number: Q8GZ42
Secondary accession number(s): Q941G9, Q9LV06

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 1, 2003
Last modified:	October 13, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)