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Q8GYM1

- GSTUM_ARATH

UniProt

Q8GYM1 - GSTUM_ARATH

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Protein
Glutathione S-transferase U22
Gene
GSTU22, At1g78340, F3F9.13
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
  2. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT1G78340-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U22 (EC:2.5.1.18)
Short name:
AtGSTU22
Alternative name(s):
GST class-tau member 22
Gene namesi
Name:GSTU22
Ordered Locus Names:At1g78340
ORF Names:F3F9.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G78340.

Subcellular locationi

Cytoplasmcytosol Inferred

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 218217Glutathione S-transferase U22
PRO_0000413567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei149 – 1491Phosphothreonine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8GYM1.
PRIDEiQ8GYM1.

Expressioni

Gene expression databases

GenevestigatoriQ8GYM1.

Interactioni

Protein-protein interaction databases

BioGridi29388. 3 interactions.
IntActiQ8GYM1. 2 interactions.
STRINGi3702.AT1G78340.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8GYM1.
SMRiQ8GYM1. Positions 1-214.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8280GST N-terminal
Add
BLAST
Domaini88 – 208121GST C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 142Glutathione binding By similarity
Regioni39 – 402Glutathione binding By similarity
Regioni53 – 542Glutathione binding By similarity
Regioni66 – 672Glutathione binding By similarity

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000125749.
InParanoidiQ8GYM1.
KOiK00799.
OMAiNEDRYFF.
PhylomeDBiQ8GYM1.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8GYM1-1 [UniParc]FASTAAdd to Basket

« Hide

MADEVILLDF WPSPFGVRAR IALREKGVEF EYREENLRDK SPLLLQMNPV    50
HKKIPVLIHN GKPVCESMNV VQYIDEVWSD KNPILPSDPY QRAQARFWVD 100
FVDTKLFEPA DKIWQTKGEE QETAKKEYIE ALKILETELG DKPYFGGDTF 150
GFVDIAMTGY YSWFEASEKL ANFSIEPECP TLMASAKRCL QRESVVQSLH 200
DSEKILAFAY KIRKIYCV 218
Length:218
Mass (Da):25,282
Last modified:March 1, 2003 - v1
Checksum:iFC90AD02D8259633
GO

Sequence cautioni

The sequence AAF71799.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013430 Genomic DNA. Translation: AAF71799.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36096.1.
AK117519 mRNA. Translation: BAC42182.1.
BT005427 mRNA. Translation: AAO63847.1.
AK176247 mRNA. Translation: BAD44010.1.
AY086469 mRNA. Translation: AAM63471.1.
RefSeqiNP_177956.1. NM_106482.1.
UniGeneiAt.34312.

Genome annotation databases

EnsemblPlantsiAT1G78340.1; AT1G78340.1; AT1G78340.
GeneIDi844169.
KEGGiath:AT1G78340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013430 Genomic DNA. Translation: AAF71799.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE36096.1 .
AK117519 mRNA. Translation: BAC42182.1 .
BT005427 mRNA. Translation: AAO63847.1 .
AK176247 mRNA. Translation: BAD44010.1 .
AY086469 mRNA. Translation: AAM63471.1 .
RefSeqi NP_177956.1. NM_106482.1.
UniGenei At.34312.

3D structure databases

ProteinModelPortali Q8GYM1.
SMRi Q8GYM1. Positions 1-214.
ModBasei Search...

Protein-protein interaction databases

BioGridi 29388. 3 interactions.
IntActi Q8GYM1. 2 interactions.
STRINGi 3702.AT1G78340.1-P.

Proteomic databases

PaxDbi Q8GYM1.
PRIDEi Q8GYM1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G78340.1 ; AT1G78340.1 ; AT1G78340 .
GeneIDi 844169.
KEGGi ath:AT1G78340.

Organism-specific databases

TAIRi AT1G78340.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000125749.
InParanoidi Q8GYM1.
KOi K00799.
OMAi NEDRYFF.
PhylomeDBi Q8GYM1.

Enzyme and pathway databases

BioCyci ARA:AT1G78340-MONOMER.

Gene expression databases

Genevestigatori Q8GYM1.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGSTUM_ARATH
AccessioniPrimary (citable) accession number: Q8GYM1
Secondary accession number(s): Q8LCP9, Q9M9F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi