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Protein

Glutathione S-transferase U22

Gene

GSTU22

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Enzyme and pathway databases

BioCyciARA:AT1G78340-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U22 (EC:2.5.1.18)
Short name:
AtGSTU22
Alternative name(s):
GST class-tau member 22
Gene namesi
Name:GSTU22
Ordered Locus Names:At1g78340
ORF Names:F3F9.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G78340
TAIRilocus:2032030 AT1G78340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004135672 – 218Glutathione S-transferase U22Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei149PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ8GYM1
PRIDEiQ8GYM1

PTM databases

iPTMnetiQ8GYM1

Expressioni

Gene expression databases

ExpressionAtlasiQ8GYM1 differential
GenevisibleiQ8GYM1 AT

Interactioni

Protein-protein interaction databases

BioGridi29388, 3 interactors
IntActiQ8GYM1, 2 interactors
STRINGi3702.AT1G78340.1

Structurei

3D structure databases

ProteinModelPortaliQ8GYM1
SMRiQ8GYM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 82GST N-terminalAdd BLAST80
Domaini88 – 208GST C-terminalAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 14Glutathione bindingBy similarity2
Regioni39 – 40Glutathione bindingBy similarity2
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
HOGENOMiHOG000125749
InParanoidiQ8GYM1
KOiK00799
OMAiLAFAYKI
OrthoDBiEOG09360PCQ
PhylomeDBiQ8GYM1

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8GYM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEVILLDF WPSPFGVRAR IALREKGVEF EYREENLRDK SPLLLQMNPV
60 70 80 90 100
HKKIPVLIHN GKPVCESMNV VQYIDEVWSD KNPILPSDPY QRAQARFWVD
110 120 130 140 150
FVDTKLFEPA DKIWQTKGEE QETAKKEYIE ALKILETELG DKPYFGGDTF
160 170 180 190 200
GFVDIAMTGY YSWFEASEKL ANFSIEPECP TLMASAKRCL QRESVVQSLH
210
DSEKILAFAY KIRKIYCV
Length:218
Mass (Da):25,282
Last modified:March 1, 2003 - v1
Checksum:iFC90AD02D8259633
GO

Sequence cautioni

The sequence AAF71799 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013430 Genomic DNA Translation: AAF71799.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE36096.1
AK117519 mRNA Translation: BAC42182.1
BT005427 mRNA Translation: AAO63847.1
AK176247 mRNA Translation: BAD44010.1
AY086469 mRNA Translation: AAM63471.1
RefSeqiNP_177956.1, NM_106482.2
UniGeneiAt.34312

Genome annotation databases

EnsemblPlantsiAT1G78340.1; AT1G78340.1; AT1G78340
GeneIDi844169
GrameneiAT1G78340.1; AT1G78340.1; AT1G78340
KEGGiath:AT1G78340

Similar proteinsi

Entry informationi

Entry nameiGSTUM_ARATH
AccessioniPrimary (citable) accession number: Q8GYM1
Secondary accession number(s): Q8LCP9, Q9M9F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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