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Protein

Putative L-ascorbate peroxidase 6

Gene

APX6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a key role in hydrogen peroxide removal.By similarity

Catalytic activityi

2 L-ascorbate + H2O2 + 2 H+ = L-ascorbate + L-dehydroascorbate + 2 H2O.

Cofactori

heme bNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119Transition state stabilizerPROSITE-ProRule annotation1
Active sitei123Proton acceptorPROSITE-ProRule annotation1
Metal bindingi244Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cellular response to oxidative stress Source: GO_Central
  • hydrogen peroxide catabolic process Source: GO_Central
  • response to reactive oxygen species Source: GO_Central
  • seed germination Source: TAIR
  • seed maturation Source: TAIR

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G32320-MONOMER

Protein family/group databases

PeroxiBasei3952 AtAPx-R

Names & Taxonomyi

Protein namesi
Recommended name:
Putative L-ascorbate peroxidase 6 (EC:1.11.1.11)
Short name:
AtAPx08
Gene namesi
Name:APX6
Ordered Locus Names:At4g32320
ORF Names:F10M6.50, F8B4.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G32320
TAIRilocus:2127766 AT4G32320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002613251 – 329Putative L-ascorbate peroxidase 6Add BLAST329

Proteomic databases

PaxDbiQ8GY91

Expressioni

Gene expression databases

ExpressionAtlasiQ8GY91 baseline and differential
GenevisibleiQ8GY91 AT

Interactioni

Protein-protein interaction databases

BioGridi14652, 1 interactor
STRINGi3702.AT4G32320.1

Structurei

3D structure databases

ProteinModelPortaliQ8GY91
SMRiQ8GY91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IQ3Y Eukaryota
COG0376 LUCA
HOGENOMiHOG000189824
InParanoidiQ8GY91
KOiK00434
OMAiQPVSWAD
OrthoDBiEOG09360FM3
PhylomeDBiQ8GY91

Family and domain databases

InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR002207 Peroxidase_I
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00459 ASPEROXIDASE
PR00458 PEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q8GY91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTTASLVK TFLFRCDSFS SFKFKCKFES PAKTRLLSPA TEKHVVRSSR
60 70 80 90 100
AWRIRCLSDD PGSSHVFVAS RRKMVVLLST VQLLSHMLPQ NGNAAEIYPV
110 120 130 140 150
MQNEIRKVVT KGKAAGVLRL VFHDAGTFEL DDHSGGINGS IAYELERPEN
160 170 180 190 200
IGLKKSLKVL AKAKVKVDEI QPVSWADMIS VAGSEAVSIC GGPTIPVVLG
210 220 230 240 250
RLDSAQPDPE GKLPPETLSA SGLKECFKRK GFSTQELVAL SGAHTIGSKG
260 270 280 290 300
FGDPTVFDNA YYKILLEKPW TSTSKMTSMV GLPSDHALVQ DDECLRWVKR
310 320
YAEDQDKFFE DFTNAYIKLV NSGAKWNML
Length:329
Mass (Da):36,240
Last modified:March 1, 2003 - v1
Checksum:iBC50726AB7B689DD
GO

Sequence cautioni

The sequence CAA16959 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA22559 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79949 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021811 Genomic DNA Translation: CAA16959.1 Sequence problems.
AL034567 Genomic DNA Translation: CAA22559.1 Sequence problems.
AL161581 Genomic DNA Translation: CAB79949.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86039.1
AK117784 mRNA Translation: BAC42431.1
BT008349 mRNA Translation: AAP37708.1
PIRiT05342
RefSeqiNP_194958.2, NM_119384.4
UniGeneiAt.31673

Genome annotation databases

EnsemblPlantsiAT4G32320.1; AT4G32320.1; AT4G32320
GeneIDi829366
GrameneiAT4G32320.1; AT4G32320.1; AT4G32320
KEGGiath:AT4G32320

Similar proteinsi

Entry informationi

Entry nameiAPX6_ARATH
AccessioniPrimary (citable) accession number: Q8GY91
Secondary accession number(s): O49360
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health