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Q8GY60

- P2C52_ARATH

UniProt

Q8GY60 - P2C52_ARATH

Protein

Probable protein phosphatase 2C 52

Gene

At4g03415

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Manganese 1By similarity
    Metal bindingi102 – 1021Manganese 2By similarity
    Metal bindingi103 – 1031Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi317 – 3171Manganese 2By similarity
    Metal bindingi363 – 3631Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: TAIR

    GO - Biological processi

    1. protein dephosphorylation Source: TAIR

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT4G03415-MONOMER.
    ARA:GQT-184-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 52 (EC:3.1.3.16)
    Short name:
    AtPP2C52
    Gene namesi
    Ordered Locus Names:At4g03415
    ORF Names:F9H3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G03415.

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Probable protein phosphatase 2C 52PRO_0000367976Add
    BLAST

    Proteomic databases

    PaxDbiQ8GY60.
    PRIDEiQ8GY60.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8GY60.

    Interactioni

    Protein-protein interaction databases

    BioGridi13221. 1 interaction.
    STRINGi3702.AT4G03415.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8GY60.
    SMRiQ8GY60. Positions 75-368.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 332267PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233897.
    OMAiDQNWLGL.
    PhylomeDBiQ8GY60.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8GY60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGCVSTSSK STCSSWSNGE KPVRRPYLGI GCCVSKRAKR TFSDHIVSLQ    50
    NLTSIPNRIT SSSKSRSSCI FTQQGRKGIN QDAMIVWEDF MSEDVTFCGV 100
    FDGHGPYGHL VARKVRDTLP VKLQFFFQTL QSKQNCSKGT RFRRNSSKSA 150
    VQEAVKEGSD EDKLKGLWGE AFLKSFKAMD KELRSHPNLD CFCSGSTGVT 200
    ILKQGSNLFM GNIGDSRAIL GSKDSNDSMV ATQLTVDLKP DLPREAERIK 250
    RCKGRVFAME DEPEVPRVWL PYDDAPGLAM ARAFGDFCLK EYGVISVPEF 300
    THRVLTDRDQ FIVLASDGVW DVLSNEEVVD IVASATSRAS AARTLVNSAA 350
    REWKLKYPTS KMDDCAVVCL FLDGKMDSES DYDEQGFSSA TNAVESDDGQ 400
    RSEPCLQRNF TVRSSSDQEN ETYGNVNTET DAEDEKTVGD QNWLGLQGVT 450
    RVNSLVQLPR FSEEKSKT 468
    Length:468
    Mass (Da):51,851
    Last modified:March 1, 2003 - v1
    Checksum:iFFE03E4F6DA93D05
    GO

    Sequence cautioni

    The sequence AF071527 differs from that shown. Reason: Frameshift at position 215.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071527 Genomic DNA. No translation available.
    CP002687 Genomic DNA. Translation: AEE82317.1.
    CP002687 Genomic DNA. Translation: AEE82318.1.
    AK117847 mRNA. Translation: BAC42488.1.
    BT005384 mRNA. Translation: AAO63448.1.
    RefSeqiNP_001190668.1. NM_001203739.1.
    NP_680572.4. NM_148206.4.
    UniGeneiAt.45457.

    Genome annotation databases

    EnsemblPlantsiAT4G03415.1; AT4G03415.1; AT4G03415.
    AT4G03415.2; AT4G03415.2; AT4G03415.
    GeneIDi827930.
    KEGGiath:AT4G03415.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF071527 Genomic DNA. No translation available.
    CP002687 Genomic DNA. Translation: AEE82317.1 .
    CP002687 Genomic DNA. Translation: AEE82318.1 .
    AK117847 mRNA. Translation: BAC42488.1 .
    BT005384 mRNA. Translation: AAO63448.1 .
    RefSeqi NP_001190668.1. NM_001203739.1.
    NP_680572.4. NM_148206.4.
    UniGenei At.45457.

    3D structure databases

    ProteinModelPortali Q8GY60.
    SMRi Q8GY60. Positions 75-368.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 13221. 1 interaction.
    STRINGi 3702.AT4G03415.1-P.

    Proteomic databases

    PaxDbi Q8GY60.
    PRIDEi Q8GY60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G03415.1 ; AT4G03415.1 ; AT4G03415 .
    AT4G03415.2 ; AT4G03415.2 ; AT4G03415 .
    GeneIDi 827930.
    KEGGi ath:AT4G03415.

    Organism-specific databases

    TAIRi AT4G03415.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233897.
    OMAi DQNWLGL.
    PhylomeDBi Q8GY60.

    Enzyme and pathway databases

    BioCyci ARA:AT4G03415-MONOMER.
    ARA:GQT-184-MONOMER.

    Gene expression databases

    Genevestigatori Q8GY60.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C52_ARATH
    AccessioniPrimary (citable) accession number: Q8GY60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3