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Q8GY60

- P2C52_ARATH

UniProt

Q8GY60 - P2C52_ARATH

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Protein
Probable protein phosphatase 2C 52
Gene
At4g03415, F9H3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Manganese 1 By similarity
Metal bindingi102 – 1021Manganese 2 By similarity
Metal bindingi103 – 1031Manganese 1; via carbonyl oxygen By similarity
Metal bindingi317 – 3171Manganese 2 By similarity
Metal bindingi363 – 3631Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: TAIR

GO - Biological processi

  1. protein dephosphorylation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G03415-MONOMER.
ARA:GQT-184-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 52 (EC:3.1.3.16)
Short name:
AtPP2C52
Gene namesi
Ordered Locus Names:At4g03415
ORF Names:F9H3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G03415.

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Probable protein phosphatase 2C 52
PRO_0000367976Add
BLAST

Proteomic databases

PaxDbiQ8GY60.
PRIDEiQ8GY60.

Expressioni

Gene expression databases

GenevestigatoriQ8GY60.

Interactioni

Protein-protein interaction databases

BioGridi13221. 1 interaction.
STRINGi3702.AT4G03415.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8GY60.
SMRiQ8GY60. Positions 75-368.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 332267PP2C-like
Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233897.
OMAiDQNWLGL.
PhylomeDBiQ8GY60.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8GY60-1 [UniParc]FASTAAdd to Basket

« Hide

MGGCVSTSSK STCSSWSNGE KPVRRPYLGI GCCVSKRAKR TFSDHIVSLQ    50
NLTSIPNRIT SSSKSRSSCI FTQQGRKGIN QDAMIVWEDF MSEDVTFCGV 100
FDGHGPYGHL VARKVRDTLP VKLQFFFQTL QSKQNCSKGT RFRRNSSKSA 150
VQEAVKEGSD EDKLKGLWGE AFLKSFKAMD KELRSHPNLD CFCSGSTGVT 200
ILKQGSNLFM GNIGDSRAIL GSKDSNDSMV ATQLTVDLKP DLPREAERIK 250
RCKGRVFAME DEPEVPRVWL PYDDAPGLAM ARAFGDFCLK EYGVISVPEF 300
THRVLTDRDQ FIVLASDGVW DVLSNEEVVD IVASATSRAS AARTLVNSAA 350
REWKLKYPTS KMDDCAVVCL FLDGKMDSES DYDEQGFSSA TNAVESDDGQ 400
RSEPCLQRNF TVRSSSDQEN ETYGNVNTET DAEDEKTVGD QNWLGLQGVT 450
RVNSLVQLPR FSEEKSKT 468
Length:468
Mass (Da):51,851
Last modified:March 1, 2003 - v1
Checksum:iFFE03E4F6DA93D05
GO

Sequence cautioni

The sequence AF071527 differs from that shown. Reason: Frameshift at position 215.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071527 Genomic DNA. No translation available.
CP002687 Genomic DNA. Translation: AEE82317.1.
CP002687 Genomic DNA. Translation: AEE82318.1.
AK117847 mRNA. Translation: BAC42488.1.
BT005384 mRNA. Translation: AAO63448.1.
RefSeqiNP_001190668.1. NM_001203739.1.
NP_680572.4. NM_148206.4.
UniGeneiAt.45457.

Genome annotation databases

EnsemblPlantsiAT4G03415.1; AT4G03415.1; AT4G03415.
AT4G03415.2; AT4G03415.2; AT4G03415.
GeneIDi827930.
KEGGiath:AT4G03415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF071527 Genomic DNA. No translation available.
CP002687 Genomic DNA. Translation: AEE82317.1 .
CP002687 Genomic DNA. Translation: AEE82318.1 .
AK117847 mRNA. Translation: BAC42488.1 .
BT005384 mRNA. Translation: AAO63448.1 .
RefSeqi NP_001190668.1. NM_001203739.1.
NP_680572.4. NM_148206.4.
UniGenei At.45457.

3D structure databases

ProteinModelPortali Q8GY60.
SMRi Q8GY60. Positions 75-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 13221. 1 interaction.
STRINGi 3702.AT4G03415.1-P.

Proteomic databases

PaxDbi Q8GY60.
PRIDEi Q8GY60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G03415.1 ; AT4G03415.1 ; AT4G03415 .
AT4G03415.2 ; AT4G03415.2 ; AT4G03415 .
GeneIDi 827930.
KEGGi ath:AT4G03415.

Organism-specific databases

TAIRi AT4G03415.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233897.
OMAi DQNWLGL.
PhylomeDBi Q8GY60.

Enzyme and pathway databases

BioCyci ARA:AT4G03415-MONOMER.
ARA:GQT-184-MONOMER.

Gene expression databases

Genevestigatori Q8GY60.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C52_ARATH
AccessioniPrimary (citable) accession number: Q8GY60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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