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Q8GXW1 (RGL2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DELLA protein RGL2
Alternative name(s):
GRAS family protein 15
Short name=AtGRAS-15
RGA-like protein 2
Scarecrow-like protein 19
Short name=AtSCL19
Gene names
Name:RGL2
Synonyms:SCL19
Ordered Locus Names:At3g03450
ORF Names:T21P5.13
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway. No effect of the BOI proteins on its stability. Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes. Upon GA application, it is degraded by the proteasome, allowing the GA signaling pathway. Acts as a major GA-response repressor of seed germination, including seed thermoinhibition. Promotes the biosynthesis of abscisic acid (ABA), especially in seed coats to maintain seed dormancy. Delays flowering and adult leaf production. Also regulates the floral development, petal, stamen and anther development, by repressing the continued growth of floral organs. Its activity is probably regulated by other phytohormones such as auxin and ethylene. Involved in the regulation of seed dormancy and germination, including glucose-induced delay of seed germination. Promotes salt tolerance. Acts as a repressor of positive regulators of trichome initiation. Required during the flagellin-derived peptide flg22-mediated growth inhibition. Contributes to the susceptibility to the biotrophic pathogen P.syringae pv. tomato and to the resistance to the necrotrophic pathogens B.cinerea A.brassicicola, probably by repressing the SA-defense pathway and preventing cell death. Prevents stress-induced reactive oxygen species (ROS) accumulation (e.g. salt stress) by acting on the ROS scavenging system, and delays ROS-induced cell death, thus promoting stress tolerance. Ref.5 Ref.6 Ref.7 Ref.8 Ref.10 Ref.11 Ref.13 Ref.14 Ref.16 Ref.17 Ref.18 Ref.20 Ref.21 Ref.22 Ref.23 Ref.26 Ref.27

Subunit structure

Interacts directly with the GID2/SLY1 component of the SCF(GID2) complex. Interacts (via N-terminus) with GID1A, GID1B and GID1C (via N-terminus). Binds to bHLH transcription factors such as PIF1, PIF4, PIF6 and SPT. Interacts with the BOI proteins BOI, BRG1, BRG2 and BRG3. Ref.9 Ref.15 Ref.25 Ref.26 Ref.28

Subcellular location

Nucleus Ref.26.

Tissue specificity

Predominantly expressed in germinating seeds, flowers and siliques. Only detectable in the inflorescence, with high levels in young flower buds and significant levels in siliques. In imbibed seeds, it is restricted to seed coats, elongating regions of pre-emergent and recently emerged radicles, endosperm (especially micropylar endosperm), and embryonic axis. Not expressed in leaves, bolting stems or roots. Ref.5 Ref.22 Ref.25 Ref.26 Ref.27

Induction

Up-regulated transiently following seed imbibition to decline rapidly as germination proceeds; this induction is delayed at supraoptimal temperature conditions (e.g. 34 degrees Celsius). Accumulates in seed coats of dormant seeds where germination does not occur after imbibition. Increased levels upon abscisic acid (ABA) treatment. Down-regulated by norflurazon (NF), an ABA biosynthesis inhibitor. Induced by stress such as glucose, salt or mannitol treatment. Ref.5 Ref.14 Ref.17 Ref.21 Ref.22 Ref.23 Ref.27

Domain

The DELLA motif is required for its GA-induced degradation but not for the interaction with GID2.

Post-translational modification

Phosphorylated. Phosphorylation on Tyr residues is required for proteasome-mediated degradation in response to gibberellic acid (GA). Dephosphorylation may be prerequisite for its degradation by the proteasome. Ref.12 Ref.19

Ubiquitinated Probable. Upon GA application or seed imbibation, it is ubiquitinated by the SCF(GID2) complex, leading to its subsequent degradation. Ref.9 Ref.12 Ref.24

Disruption phenotype

Higher germination rate in the presence of glucose and at supraoptimal temperature conditions. Rga, gai, rgl1, rgl2 and rgl3 pentuple mutant displays constitutive GA responses even in the absence of GA treatment. Ref.14 Ref.23 Ref.28

Sequence similarities

Belongs to the GRAS family. DELLA subfamily.

Ontologies

Keywords
   Biological processDifferentiation
Flowering
Gibberellin signaling pathway
Plant defense
Transcription
Transcription regulation
   Cellular componentNucleus
   Molecular functionDevelopmental protein
Repressor
   PTMPhosphoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

defense response

Inferred from electronic annotation. Source: UniProtKB-KW

flower development

Inferred from electronic annotation. Source: UniProtKB-KW

gibberellic acid mediated signaling pathway

Traceable author statement Ref.5. Source: TAIR

hyperosmotic salinity response

Inferred from genetic interaction Ref.16. Source: TAIR

jasmonic acid mediated signaling pathway

Inferred from genetic interaction Ref.20. Source: TAIR

negative regulation of gibberellic acid mediated signaling pathway

Traceable author statement Ref.12. Source: TAIR

negative regulation of seed germination

Inferred from mutant phenotype Ref.5. Source: TAIR

regulation of reactive oxygen species metabolic process

Inferred from genetic interaction Ref.21. Source: TAIR

regulation of seed dormancy process

Inferred from genetic interaction Ref.13. Source: TAIR

regulation of seed germination

Inferred from genetic interaction Ref.13. Source: TAIR

response to abscisic acid

Inferred from genetic interaction Ref.16. Source: TAIR

response to ethylene

Inferred from genetic interaction Ref.16. Source: TAIR

response to gibberellin

Inferred from expression pattern Ref.19Ref.22. Source: TAIR

response to salt stress

Inferred from genetic interaction Ref.16. Source: TAIR

salicylic acid mediated signaling pathway

Inferred from genetic interaction Ref.20. Source: TAIR

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay Ref.12. Source: TAIR

   Molecular_functionprotein binding

Inferred from physical interaction Ref.26. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from sequence or structural similarity PubMed 11118137Ref.5. Source: TAIR

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GID1AQ9MAA73EBI-963665,EBI-963597
GID1CQ940G63EBI-963665,EBI-963794

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547DELLA protein RGL2
PRO_0000132237

Regions

Motif44 – 485DELLA motif
Motif66 – 705LEXLE motif
Motif87 – 915VHYNP motif
Motif286 – 2905VHIID
Motif385 – 3895LXXLL motif

Experimental info

Mutagenesis44 – 485Missing: Induces a resistance to GA-mediated degradation.
Mutagenesis521Y → A or E: Induces a resistance to GA-mediated degradation. Ref.12 Ref.19
Mutagenesis521Y → F: Normal GA-mediated degradation. Ref.12 Ref.19
Mutagenesis571S → D: No effect. Ref.12
Mutagenesis861S → D: No effect. Ref.12
Mutagenesis891Y → A or E: Induces a resistance to GA-mediated degradation. Ref.19
Mutagenesis891Y → F: Normal GA-mediated degradation. Ref.19
Mutagenesis1031S → D: No effect. Ref.12
Mutagenesis2121S → D: No effect. Ref.12
Mutagenesis2231Y → A or E: Induces a resistance to GA-mediated degradation. Ref.19
Mutagenesis2231Y → F: Normal GA-mediated degradation. Ref.19
Mutagenesis2591Y → A: Induces a partial resistance to GA-mediated degradation. Ref.19
Mutagenesis2711T → C: Induces a decrease to GA-mediated degradation. Ref.12
Mutagenesis2711T → E: Null mutant; induces a resistance to GA-mediated degradation. Ref.12
Mutagenesis3191T → C: No effect. Ref.12
Mutagenesis3191T → E: Induces a resistance to GA-mediated degradation. Ref.12
Mutagenesis3811S → D: No effect. Ref.12
Mutagenesis4111T → C: No effect. Ref.12
Mutagenesis4111T → E: Induces a resistance to GA-mediated degradation. Ref.12
Mutagenesis4351Y → A or E: Induces a resistance to GA-mediated degradation. Ref.19
Mutagenesis4351Y → F: Induces a resistance to GA-mediated degradation. Ref.19
Mutagenesis4361S → D: No effect. Ref.12
Mutagenesis4371S → D: No effect. Ref.12
Mutagenesis4411S → C: No effect. Ref.12
Mutagenesis4411S → D: Induces a resistance to GA-mediated degradation. Ref.12
Mutagenesis4561S → D: No effect. Ref.12
Mutagenesis4811T → E: No effect. Ref.12
Mutagenesis5011S → D: No effect. Ref.12
Mutagenesis5081S → D: No effect. Ref.12
Mutagenesis5351T → C: No effect. Ref.12
Mutagenesis5351T → E: Induces a resistance to GA-mediated degradation. Ref.12
Mutagenesis5421S → C: No effect. Ref.12
Mutagenesis5421S → D: Induces a resistance to GA-mediated degradation. Ref.12
Sequence conflict2101A → T in BAC42642. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8GXW1 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: C4D18D5951D95634

FASTA54760,494
        10         20         30         40         50         60 
MKRGYGETWD PPPKPLPASR SGEGPSMADK KKADDDNNNS NMDDELLAVL GYKVRSSEMA 

        70         80         90        100        110        120 
EVAQKLEQLE MVLSNDDVGS TVLNDSVHYN PSDLSNWVES MLSELNNPAS SDLDTTRSCV 

       130        140        150        160        170        180 
DRSEYDLRAI PGLSAFPKEE EVFDEEASSK RIRLGSWCES SDESTRSVVL VDSQETGVRL 

       190        200        210        220        230        240 
VHALVACAEA IHQENLNLAD ALVKRVGTLA GSQAGAMGKV ATYFAQALAR RIYRDYTAET 

       250        260        270        280        290        300 
DVCAAVNPSF EEVLEMHFYE SCPYLKFAHF TANQAILEAV TTARRVHVID LGLNQGMQWP 

       310        320        330        340        350        360 
ALMQALALRP GGPPSFRLTG IGPPQTENSD SLQQLGWKLA QFAQNMGVEF EFKGLAAESL 

       370        380        390        400        410        420 
SDLEPEMFET RPESETLVVN SVFELHRLLA RSGSIEKLLN TVKAIKPSIV TVVEQEANHN 

       430        440        450        460        470        480 
GIVFLDRFNE ALHYYSSLFD SLEDSYSLPS QDRVMSEVYL GRQILNVVAA EGSDRVERHE 

       490        500        510        520        530        540 
TAAQWRIRMK SAGFDPIHLG SSAFKQASML LSLYATGDGY RVEENDGCLM IGWQTRPLIT 


TSAWKLA 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes."
Pysh L.D., Wysocka-Diller J.W., Camilleri C., Bouchez D., Benfey P.N.
Plant J. 18:111-119(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Gibberellin regulates Arabidopsis seed germination via RGL2, a GAI/RGA-like gene whose expression is up-regulated following imbibition."
Lee S., Cheng H., King K.E., Wang W., He Y., Hussain A., Lo J., Harberd N.P., Peng J.
Genes Dev. 16:646-658(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
[6]"Auxin promotes Arabidopsis root growth by modulating gibberellin response."
Fu X., Harberd N.P.
Nature 421:740-743(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Ethylene regulates Arabidopsis development via the modulation of DELLA protein growth repressor function."
Achard P., Vriezen W.H., Van Der Straeten D., Harberd N.P.
Plant Cell 15:2816-2825(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Gibberellin regulates Arabidopsis floral development via suppression of DELLA protein function."
Cheng H., Qin L., Lee S., Fu X., Richards D.E., Cao D., Luo D., Harberd N.P., Peng J.
Development 131:1055-1064(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"Della proteins and gibberellin-regulated seed germination and floral development in Arabidopsis."
Tyler L., Thomas S.G., Hu J., Dill A., Alonso J.M., Ecker J.R., Sun T.-P.
Plant Physiol. 135:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROBABLE UBIQUITINATION, DEGRADATION, INTERACTION WITH GID2.
[10]"Floral homeotic genes are targets of gibberellin signaling in flower development."
Yu H., Ito T., Zhao Y., Peng J., Kumar P., Meyerowitz E.M.
Proc. Natl. Acad. Sci. U.S.A. 101:7827-7832(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[11]"Loss of function of four DELLA genes leads to light- and gibberellin-independent seed germination in Arabidopsis."
Cao D., Hussain A., Cheng H., Peng J.
Planta 223:105-113(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"Identification of the conserved serine/threonine residues important for gibberellin-sensitivity of Arabidopsis RGL2 protein."
Hussain A., Cao D., Cheng H., Wen Z., Peng J.
Plant J. 44:88-99(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: PROBABLE UBIQUITINATION, DEGRADATION, PHOSPHORYLATION, MUTAGENESIS OF 48-ASP--ALA-52; TYR-52; SER-57; SER-86; SER-103; SER-212; THR-271; THR-319; SER-381; THR-411; SER-436; SER-437; SER-441; SER-456; THR-481; SER-501; SER-508; THR-535 AND SER-542.
[13]"DELLA-mediated cotyledon expansion breaks coat-imposed seed dormancy."
Penfield S., Gilday A.D., Halliday K.J., Graham I.A.
Curr. Biol. 16:2366-2370(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"Phytohormone signalling pathways interact with sugars during seed germination and seedling development."
Yuan K., Wysocka-Diller J.
J. Exp. Bot. 57:3359-3367(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY GLUCOSE.
[15]"Identification and characterization of Arabidopsis gibberellin receptors."
Nakajima M., Shimada A., Takashi Y., Kim Y.C., Park S.H., Ueguchi-Tanaka M., Suzuki H., Katoh E., Iuchi S., Kobayashi M., Maeda T., Matsuoka M., Yamaguchi I.
Plant J. 46:880-889(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GID1A; GID1B AND GID1C.
[16]"Integration of plant responses to environmentally activated phytohormonal signals."
Achard P., Cheng H., De Grauwe L., Decat J., Schoutteten H., Moritz T., Van Der Straeten D., Peng J., Harberd N.P.
Science 311:91-94(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[17]"Seed germination of GA-insensitive sleepy1 mutants does not require RGL2 protein disappearance in Arabidopsis."
Ariizumi T., Steber C.M.
Plant Cell 19:791-804(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[18]"Genetic and molecular regulation by DELLA proteins of trichome development in Arabidopsis."
Gan Y., Yu H., Peng J., Broun P.
Plant Physiol. 145:1031-1042(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[19]"Identification of conserved tyrosine residues important for gibberellin sensitivity of Arabidopsis RGL2 protein."
Hussain A., Cao D., Peng J.
Planta 226:475-483(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION OF TYR RESIDUES, MUTAGENESIS OF TYR-52; TYR-89; TYR-223; TYR-259 AND TYR-435.
[20]"DELLAs control plant immune responses by modulating the balance of jasmonic acid and salicylic acid signaling."
Navarro L., Bari R., Achard P., Lison P., Nemri A., Harberd N.P., Jones J.D.G.
Curr. Biol. 18:650-655(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: cv. Landsberg erecta.
[21]"Plant DELLAs restrain growth and promote survival of adversity by reducing the levels of reactive oxygen species."
Achard P., Renou J.-P., Berthome R., Harberd N.P., Genschik P.
Curr. Biol. 18:656-660(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION BY SALT AND MANNITOL TREATMENT.
[22]"The gibberellic acid signaling repressor RGL2 inhibits Arabidopsis seed germination by stimulating abscisic acid synthesis and ABI5 activity."
Piskurewicz U., Jikumaru Y., Kinoshita N., Nambara E., Kamiya Y., Lopez-Molina L.
Plant Cell 20:2729-2745(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION BY ABA, TISSUE SPECIFICITY.
[23]"High temperature-induced abscisic acid biosynthesis and its role in the inhibition of gibberellin action in Arabidopsis seeds."
Toh S., Imamura A., Watanabe A., Nakabayashi K., Okamoto M., Jikumaru Y., Hanada A., Aso Y., Ishiyama K., Tamura N., Iuchi S., Kobayashi M., Yamaguchi S., Kamiya Y., Nambara E., Kawakami N.
Plant Physiol. 146:1368-1385(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY IMBIBITION.
[24]"Biochemical insights on degradation of Arabidopsis DELLA proteins gained from a cell-free assay system."
Wang F., Zhu D., Huang X., Li S., Gong Y., Yao Q., Fu X., Fan L.-M., Deng X.W.
Plant Cell 21:2378-2390(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DEGRADATION BY PROTEASOME.
[25]"Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants."
Suzuki H., Park S.-H., Okubo K., Kitamura J., Ueguchi-Tanaka M., Iuchi S., Katoh E., Kobayashi M., Yamaguchi I., Matsuoka M., Asami T., Nakajima M.
Plant J. 60:48-55(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INTERACTION WITH GID1A; GID1B AND GID1C.
[26]"Transcriptional diversification and functional conservation between DELLA proteins in Arabidopsis."
Gallego-Bartolome J., Minguet E.G., Marin J.A., Prat S., Blazquez M.A., Alabadi D.
Mol. Biol. Evol. 27:1247-1256(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH PIF1; PIF4; PIF6 AND SPT.
Strain: cv. Landsberg erecta.
[27]"A seed coat bedding assay shows that RGL2-dependent release of abscisic acid by the endosperm controls embryo growth in Arabidopsis dormant seeds."
Lee K.P., Piskurewicz U., Tureckova V., Strnad M., Lopez-Molina L.
Proc. Natl. Acad. Sci. U.S.A. 107:19108-19113(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION DURING IMBIBITION, TISSUE SPECIFICITY.
[28]"DELLA proteins and their interacting RING Finger proteins repress gibberellin responses by binding to the promoters of a subset of gibberellin-responsive genes in Arabidopsis."
Park J., Nguyen K.T., Park E., Jeon J.S., Choi G.
Plant Cell 25:927-943(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BOI; BRG1; BRG2 AND BRG3, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Kiss of life - Issue 137 of April 2012

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC009895 Genomic DNA. Translation: AAF01590.1.
CP002686 Genomic DNA. Translation: AEE73945.1.
AK118009 mRNA. Translation: BAC42642.1.
RefSeqNP_186995.1. NM_111216.2.
UniGeneAt.18489.
At.67027.

3D structure databases

ProteinModelPortalQ8GXW1.
SMRQ8GXW1. Positions 44-106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid6584. 10 interactions.
DIPDIP-37661N.
IntActQ8GXW1. 3 interactions.
MINTMINT-8069272.
STRING3702.AT3G03450.1-P.

Proteomic databases

PRIDEQ8GXW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G03450.1; AT3G03450.1; AT3G03450.
GeneID821251.
KEGGath:AT3G03450.

Organism-specific databases

GeneFarm4240. 427.
TAIRAT3G03450.

Phylogenomic databases

eggNOGNOG243696.
HOGENOMHOG000238577.
InParanoidQ8GXW1.
KOK14494.
OMAMLSELNN.
PhylomeDBQ8GXW1.

Gene expression databases

GenevestigatorQ8GXW1.

Family and domain databases

InterProIPR021914. TF_DELLA_N.
IPR005202. TF_GRAS.
[Graphical view]
PfamPF12041. DELLA. 1 hit.
PF03514. GRAS. 1 hit.
[Graphical view]
PROSITEPS50985. GRAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRGL2_ARATH
AccessionPrimary (citable) accession number: Q8GXW1
Secondary accession number(s): Q9SRP9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 11, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names