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Protein

Thioredoxin-like protein CXXS2

Gene

CXXS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses low disulfide reductase activity, but efficient protein disulfide isomerase activity. Does not possess deglutathionylation activity.1 Publication

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: TAIR
  2. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
  2. glycerol ether metabolic process Source: InterPro
  3. protein folding Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiREACT_294404. Synthesis and interconversion of nucleotide di- and triphosphates.
REACT_310971. Oxidative Stress Induced Senescence.
REACT_333313. Detoxification of Reactive Oxygen Species.
REACT_334386. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-like protein CXXS2
Short name:
AtCXXS2
Alternative name(s):
Mono-cysteine thioredoxin 2
Gene namesi
Name:CXXS2
Ordered Locus Names:At2g40790
ORF Names:T7D17.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G40790.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosol Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Thioredoxin-like protein CXXS2PRO_0000394547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ8GXV2.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

GenevestigatoriQ8GXV2.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G40790.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8GXV2.
SMRiQ8GXV2. Positions 40-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 148126ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi5 – 2117Cys-richAdd
BLAST

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000292977.
InParanoidiQ8GXV2.
KOiK03671.
OMAiDGRQVDK.
PhylomeDBiQ8GXV2.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8GXV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNHCTRIPC CKKVCSCICC CNRRNKTQAR SQKGSYFIKG KVHPVSRMEK
60 70 80 90 100
WEEKITEANS HGKILVVNFK ASWCLPSKTI LPIYQELAST YTSMIFVTID
110 120 130 140 150
VEELAEFSHE WNVDATPTVV FLKDGRQMDK LVGGDAAELQ KKTAAAANLL

LRQS
Length:154
Mass (Da):17,314
Last modified:February 28, 2003 - v1
Checksum:iA9B0DB455E890401
GO

Sequence cautioni

The sequence AAC49350.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35639 Genomic DNA. Translation: AAC49350.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC09879.1.
AK118023 mRNA. Translation: BAC42656.1.
BT003671 mRNA. Translation: AAO39899.1.
PIRiH84833.
RefSeqiNP_181611.2. NM_129642.3.
UniGeneiAt.46001.
At.53090.

Genome annotation databases

EnsemblPlantsiAT2G40790.1; AT2G40790.1; AT2G40790.
GeneIDi818676.
KEGGiath:AT2G40790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35639 Genomic DNA. Translation: AAC49350.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC09879.1.
AK118023 mRNA. Translation: BAC42656.1.
BT003671 mRNA. Translation: AAO39899.1.
PIRiH84833.
RefSeqiNP_181611.2. NM_129642.3.
UniGeneiAt.46001.
At.53090.

3D structure databases

ProteinModelPortaliQ8GXV2.
SMRiQ8GXV2. Positions 40-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G40790.1-P.

Proteomic databases

PRIDEiQ8GXV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G40790.1; AT2G40790.1; AT2G40790.
GeneIDi818676.
KEGGiath:AT2G40790.

Organism-specific databases

TAIRiAT2G40790.

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000292977.
InParanoidiQ8GXV2.
KOiK03671.
OMAiDGRQVDK.
PhylomeDBiQ8GXV2.

Enzyme and pathway databases

ReactomeiREACT_294404. Synthesis and interconversion of nucleotide di- and triphosphates.
REACT_310971. Oxidative Stress Induced Senescence.
REACT_333313. Detoxification of Reactive Oxygen Species.
REACT_334386. The NLRP3 inflammasome.

Gene expression databases

GenevestigatoriQ8GXV2.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Intron position as an evolutionary marker of thioredoxins and thioredoxin domains."
    Sahrawy M., Hecht V., Lopez Jaramillo J., Chueca A., Chartier Y., Meyer Y.
    J. Mol. Evol. 42:422-431(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "AtCXXS: atypical members of the Arabidopsis thaliana thioredoxin h family with a remarkably high disulfide isomerase activity."
    Serrato A.J., Guilleminot J., Meyer Y., Vignols F.
    Physiol. Plantarum 133:611-622(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Comparative genomic study of the thioredoxin family in photosynthetic organisms with emphasis on Populus trichocarpa."
    Chibani K., Wingsle G., Jacquot J.P., Gelhaye E., Rouhier N.
    Mol. Plant 2:308-322(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiCXXS2_ARATH
AccessioniPrimary (citable) accession number: Q8GXV2
Secondary accession number(s): Q38878
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 14, 2010
Last sequence update: February 28, 2003
Last modified: March 31, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved cysteine (here Ser-77), present in the redox-active center, which is one of the conserved features of the thioredoxin family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.