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Q8GXV2 (CXXS2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin-like protein CXXS2

Short name=AtCXXS2
Alternative name(s):
Mono-cysteine thioredoxin 2
Gene names
Name:CXXS2
Ordered Locus Names:At2g40790
ORF Names:T7D17.3
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possesses low disulfide reductase activity, but efficient protein disulfide isomerase activity. Does not possess deglutathionylation activity. Ref.6

Subcellular location

Cytoplasm Ref.6.

Tissue specificity

Ubiquitous. Ref.6

Sequence similarities

Belongs to the thioredoxin family.

Contains 1 thioredoxin domain.

Caution

Lacks the conserved cysteine (here Ser-77), present in the redox-active center, which is one of the conserved features of the thioredoxin family.

Sequence caution

The sequence AAC49350.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 154154Thioredoxin-like protein CXXS2
PRO_0000394547

Regions

Domain23 – 148126Thioredoxin
Compositional bias5 – 2117Cys-rich

Amino acid modifications

Modified residue311Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8GXV2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: A9B0DB455E890401

FASTA15417,314
        10         20         30         40         50         60 
MGNHCTRIPC CKKVCSCICC CNRRNKTQAR SQKGSYFIKG KVHPVSRMEK WEEKITEANS 

        70         80         90        100        110        120 
HGKILVVNFK ASWCLPSKTI LPIYQELAST YTSMIFVTID VEELAEFSHE WNVDATPTVV 

       130        140        150 
FLKDGRQMDK LVGGDAAELQ KKTAAAANLL LRQS 

« Hide

References

« Hide 'large scale' references
[1]"Intron position as an evolutionary marker of thioredoxins and thioredoxin domains."
Sahrawy M., Hecht V., Lopez Jaramillo J., Chueca A., Chartier Y., Meyer Y.
J. Mol. Evol. 42:422-431(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Columbia.
[2]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"AtCXXS: atypical members of the Arabidopsis thaliana thioredoxin h family with a remarkably high disulfide isomerase activity."
Serrato A.J., Guilleminot J., Meyer Y., Vignols F.
Physiol. Plantarum 133:611-622(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]"Comparative genomic study of the thioredoxin family in photosynthetic organisms with emphasis on Populus trichocarpa."
Chibani K., Wingsle G., Jacquot J.P., Gelhaye E., Rouhier N.
Mol. Plant 2:308-322(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U35639 Genomic DNA. Translation: AAC49350.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC09879.1.
AK118023 mRNA. Translation: BAC42656.1.
BT003671 mRNA. Translation: AAO39899.1.
PIRH84833.
RefSeqNP_181611.2. NM_129642.3.
UniGeneAt.46001.
At.53090.

3D structure databases

ProteinModelPortalQ8GXV2.
SMRQ8GXV2. Positions 40-145.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT2G40790.1-P.

Proteomic databases

PRIDEQ8GXV2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G40790.1; AT2G40790.1; AT2G40790.
GeneID818676.
KEGGath:AT2G40790.

Organism-specific databases

TAIRAT2G40790.

Phylogenomic databases

eggNOGCOG0526.
HOGENOMHOG000292977.
InParanoidQ8GXV2.
KOK03671.
OMACTRIPCC.
PhylomeDBQ8GXV2.

Gene expression databases

GenevestigatorQ8GXV2.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERPTHR10438. PTHR10438. 1 hit.
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCXXS2_ARATH
AccessionPrimary (citable) accession number: Q8GXV2
Secondary accession number(s): Q38878
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names