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Q8GXV2

- CXXS2_ARATH

UniProt

Q8GXV2 - CXXS2_ARATH

Protein

Thioredoxin-like protein CXXS2

Gene

CXXS2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Possesses low disulfide reductase activity, but efficient protein disulfide isomerase activity. Does not possess deglutathionylation activity.1 Publication

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: TAIR
    2. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro
    2. glycerol ether metabolic process Source: InterPro
    3. protein folding Source: GOC

    Keywords - Molecular functioni

    Isomerase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin-like protein CXXS2
    Short name:
    AtCXXS2
    Alternative name(s):
    Mono-cysteine thioredoxin 2
    Gene namesi
    Name:CXXS2
    Ordered Locus Names:At2g40790
    ORF Names:T7D17.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G40790.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosol Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 154154Thioredoxin-like protein CXXS2PRO_0000394547Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ8GXV2.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    GenevestigatoriQ8GXV2.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G40790.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8GXV2.
    SMRiQ8GXV2. Positions 40-145.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 148126ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi5 – 2117Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the thioredoxin family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000292977.
    InParanoidiQ8GXV2.
    KOiK03671.
    OMAiCTRIPCC.
    PhylomeDBiQ8GXV2.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PANTHERiPTHR10438. PTHR10438. 1 hit.
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8GXV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNHCTRIPC CKKVCSCICC CNRRNKTQAR SQKGSYFIKG KVHPVSRMEK    50
    WEEKITEANS HGKILVVNFK ASWCLPSKTI LPIYQELAST YTSMIFVTID 100
    VEELAEFSHE WNVDATPTVV FLKDGRQMDK LVGGDAAELQ KKTAAAANLL 150
    LRQS 154
    Length:154
    Mass (Da):17,314
    Last modified:March 1, 2003 - v1
    Checksum:iA9B0DB455E890401
    GO

    Sequence cautioni

    The sequence AAC49350.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35639 Genomic DNA. Translation: AAC49350.1. Sequence problems.
    CP002685 Genomic DNA. Translation: AEC09879.1.
    AK118023 mRNA. Translation: BAC42656.1.
    BT003671 mRNA. Translation: AAO39899.1.
    PIRiH84833.
    RefSeqiNP_181611.2. NM_129642.3.
    UniGeneiAt.46001.
    At.53090.

    Genome annotation databases

    EnsemblPlantsiAT2G40790.1; AT2G40790.1; AT2G40790.
    GeneIDi818676.
    KEGGiath:AT2G40790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35639 Genomic DNA. Translation: AAC49350.1 . Sequence problems.
    CP002685 Genomic DNA. Translation: AEC09879.1 .
    AK118023 mRNA. Translation: BAC42656.1 .
    BT003671 mRNA. Translation: AAO39899.1 .
    PIRi H84833.
    RefSeqi NP_181611.2. NM_129642.3.
    UniGenei At.46001.
    At.53090.

    3D structure databases

    ProteinModelPortali Q8GXV2.
    SMRi Q8GXV2. Positions 40-145.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G40790.1-P.

    Proteomic databases

    PRIDEi Q8GXV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G40790.1 ; AT2G40790.1 ; AT2G40790 .
    GeneIDi 818676.
    KEGGi ath:AT2G40790.

    Organism-specific databases

    TAIRi AT2G40790.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000292977.
    InParanoidi Q8GXV2.
    KOi K03671.
    OMAi CTRIPCC.
    PhylomeDBi Q8GXV2.

    Gene expression databases

    Genevestigatori Q8GXV2.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    PANTHERi PTHR10438. PTHR10438. 1 hit.
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Intron position as an evolutionary marker of thioredoxins and thioredoxin domains."
      Sahrawy M., Hecht V., Lopez Jaramillo J., Chueca A., Chartier Y., Meyer Y.
      J. Mol. Evol. 42:422-431(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Columbia.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "AtCXXS: atypical members of the Arabidopsis thaliana thioredoxin h family with a remarkably high disulfide isomerase activity."
      Serrato A.J., Guilleminot J., Meyer Y., Vignols F.
      Physiol. Plantarum 133:611-622(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "Comparative genomic study of the thioredoxin family in photosynthetic organisms with emphasis on Populus trichocarpa."
      Chibani K., Wingsle G., Jacquot J.P., Gelhaye E., Rouhier N.
      Mol. Plant 2:308-322(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiCXXS2_ARATH
    AccessioniPrimary (citable) accession number: Q8GXV2
    Secondary accession number(s): Q38878
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Caution

    Lacks the conserved cysteine (here Ser-77), present in the redox-active center, which is one of the conserved features of the thioredoxin family.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3