Reviewed, UniProtKB/Swiss-Prot Q8GXJ1 (HDA15_ARATH)

Names and origin

Protein names

Recommended name:
    Histone deacetylase 15
    EC=3.5.1.98

Gene names

Name:	HDA15
Ordered Locus Names:	At3g18520
ORF Names:	MYF24_23

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. Type 2 subfamily. Contains 1 RanBP2-type zinc finger.
Sequence caution	The sequence BAB01118.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Chromatin regulator Hydrolase Repressor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA mediated transformation Inferred from mutant phenotype. Source: TAIR chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q8GXJ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Histone deacetylase 15		PRO_0000280091
Regions
	Zinc finger	86 – 115	30	RanBP2-type
	Region	149 – 462	314	Histone deacetylase
	Compositional bias	58 – 77	20	Asp-rich
Sites
	Active site	277	1	By similarity
Experimental info
	Sequence conflict	172	1	P → T in AAM63340. Ref.3
	Sequence conflict	253	1	T → A in AAM63340. Ref.3
	Sequence conflict	342	1	I → N in AAM63340. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: CFDCED8CFCBEE99A	FASTA	552	60,049
	10 20 30 40 50 60 MVVETIERSC EGSKRRHVNG GDIAVPCSGE ECSNGDINVA PGVSAKRARV SREMTFEDIY 70 80 90 100 110 120 GADALLNDDD DEDDDCDWEP VQAPMEFVKW CCVNCTMSNP GDMVHCCICG EHKESGILRH 130 140 150 160 170 180 GYLASPFFKD TGLIEVEEKY GGSSSATSST AVGFDERMLL HSEFEVKAQP HPERPDRLRA 190 200 210 220 230 240 IAASLATAGV FPGRCLPINA REITKQELQM VHTSEHVDAV DTTSQLLYSY FTSDTYANEY 250 260 270 280 290 300 SARAARLAAG LCTDLATDIF TGRVKNGFAL VRPPGHHAGV RHAMGFCLHN NAAVAALVAQ 310 320 330 340 350 360 AAGAKKVLIV DWDVHHGNGT QEIFEQNKSV LYISLHRHEG GIFYPGTGAA DEVGSNGGEG 370 380 390 400 410 420 YCVNVPWSCG GVGDKDYIFA FQHVVLPIAS AFSPDFVIIS AGFDAARGDP LGCCDVTPAG 430 440 450 460 470 480 YSRMTQMLGD LCGGKMLVIL EGGYNLRSIS ASATAVIKVL LGENPENELP IATTPSVAGL 490 500 510 520 530 540 QTVLDVLNIQ LEFWPSLAIS YSKLLSELEA RLIENKKNQM KRKVVRVPTW WKWGRKKLLY 550 NFLSARMISR SK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes." Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A. Nucleic Acids Res. 30:5036-5055(2002) [PubMed: 12466527] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB026658 Genomic DNA. Translation: BAB01118.1. Sequence problems. AK118211 mRNA. Translation: BAC42833.1. AY086135 mRNA. Translation: AAM63340.1.
IPI	IPI00530107.
3D structure databases
HSSP	HSSP built from PDB template 1ZZ0 based on UniProtKB Q70I53.
SMR	Q8GXJ1. Positions 148-516.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8GXJ1.
Proteomic databases
PRIDE	Q8GXJ1.
Genome annotation databases
GenomeReviews	Gene locus AT3G18520 in contig BA000014_GR.
Organism-specific databases
TAIR	At3g18520.
Phylogenomic databases
eggNOG	KOG1343.
HOGENOM	HBG746265.
InParanoid	Q8GXJ1.
PhylomeDB	Q8GXJ1.
Gene expression databases
Genevestigator	Q8GXJ1.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR001876. Znf_RanBP2. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PRINTS	PR01270. HDASUPER.
PROSITE	PS01358. ZF_RANBP2_1. 1 hit. PS50199. ZF_RANBP2_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HDA15_ARATH

Accession

Primary (citable) accession number: Q8GXJ1
Secondary accession number(s): Q3EB46, Q8LD93, Q9LS38

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)