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Q8GXJ1 (HDA15_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 15

EC=3.5.1.98
Gene names
Name:HDA15
Ordered Locus Names:At3g18520
ORF Names:MYF24_23
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Contains 1 RanBP2-type zinc finger.

Sequence caution

The sequence BAB01118.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8GXJ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Histone deacetylase 15
PRO_0000280091

Regions

Zinc finger86 – 11530RanBP2-type
Region149 – 462314Histone deacetylase
Compositional bias58 – 7720Asp-rich

Sites

Active site2771 By similarity

Experimental info

Sequence conflict1721P → T in AAM63340. Ref.4
Sequence conflict2531A → T in BAC42833. Ref.3
Sequence conflict3421N → I in BAC42833. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 16, 2011. Version 2.
Checksum: 08BC902FCC99B886

FASTA55260,020
        10         20         30         40         50         60 
MVVETIERSC EGSKRRHVNG GDIAVPCSGE ECSNGDINVA PGVSAKRARV SREMTFEDIY 

        70         80         90        100        110        120 
GADALLNDDD DEDDDCDWEP VQAPMEFVKW CCVNCTMSNP GDMVHCCICG EHKESGILRH 

       130        140        150        160        170        180 
GYLASPFFKD TGLIEVEEKY GGSSSATSST AVGFDERMLL HSEFEVKAQP HPERPDRLRA 

       190        200        210        220        230        240 
IAASLATAGV FPGRCLPINA REITKQELQM VHTSEHVDAV DTTSQLLYSY FTSDTYANEY 

       250        260        270        280        290        300 
SARAARLAAG LCADLATDIF TGRVKNGFAL VRPPGHHAGV RHAMGFCLHN NAAVAALVAQ 

       310        320        330        340        350        360 
AAGAKKVLIV DWDVHHGNGT QEIFEQNKSV LYISLHRHEG GNFYPGTGAA DEVGSNGGEG 

       370        380        390        400        410        420 
YCVNVPWSCG GVGDKDYIFA FQHVVLPIAS AFSPDFVIIS AGFDAARGDP LGCCDVTPAG 

       430        440        450        460        470        480 
YSRMTQMLGD LCGGKMLVIL EGGYNLRSIS ASATAVIKVL LGENPENELP IATTPSVAGL 

       490        500        510        520        530        540 
QTVLDVLNIQ LEFWPSLAIS YSKLLSELEA RLIENKKNQM KRKVVRVPTW WKWGRKKLLY 

       550 
NFLSARMISR SK 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Full-length cDNA from Arabidopsis thaliana."
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB026658 Genomic DNA. Translation: BAB01118.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE76110.1.
AK118211 mRNA. Translation: BAC42833.1.
AY086135 mRNA. Translation: AAM63340.1.
RefSeqNP_566612.1. NM_112737.2.
UniGeneAt.38541.

3D structure databases

ProteinModelPortalQ8GXJ1.
SMRQ8GXJ1. Positions 149-497.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid6715. 3 interactions.

Proteomic databases

PaxDbQ8GXJ1.
PRIDEQ8GXJ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G18520.1; AT3G18520.1; AT3G18520. [Q8GXJ1-1]
GeneID821382.
KEGGath:AT3G18520.

Organism-specific databases

TAIRAT3G18520.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000225183.
InParanoidQ8GXJ1.
KOK11407.

Enzyme and pathway databases

BioCycARA:AT3G18520-MONOMER.
ARA:GQT-826-MONOMER.

Gene expression databases

GenevestigatorQ8GXJ1.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
PROSITEPS01358. ZF_RANBP2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHDA15_ARATH
AccessionPrimary (citable) accession number: Q8GXJ1
Secondary accession number(s): F4J8S2 expand/collapse secondary AC list , Q3EB46, Q8LD93, Q9LS38
Entry history
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names