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Q8GXJ1

- HDA15_ARATH

UniProt

Q8GXJ1 - HDA15_ARATH

Protein

Histone deacetylase 15

Gene

HDA15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei277 – 2771By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri86 – 11530RanBP2-typeAdd
    BLAST

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT3G18520-MONOMER.
    ARA:GQT-826-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 15 (EC:3.5.1.98)
    Gene namesi
    Name:HDA15
    Ordered Locus Names:At3g18520
    ORF Names:MYF24_23
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G18520.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Histone deacetylase 15PRO_0000280091Add
    BLAST

    Proteomic databases

    PaxDbiQ8GXJ1.
    PRIDEiQ8GXJ1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8GXJ1.

    Interactioni

    Protein-protein interaction databases

    BioGridi6715. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8GXJ1.
    SMRiQ8GXJ1. Positions 149-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni149 – 462314Histone deacetylaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi58 – 7720Asp-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 RanBP2-type zinc finger.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri86 – 11530RanBP2-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000225183.
    InParanoidiQ8GXJ1.
    KOiK11407.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR001876. Znf_RanBP2.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.
    PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q8GXJ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MVVETIERSC EGSKRRHVNG GDIAVPCSGE ECSNGDINVA PGVSAKRARV    50
    SREMTFEDIY GADALLNDDD DEDDDCDWEP VQAPMEFVKW CCVNCTMSNP 100
    GDMVHCCICG EHKESGILRH GYLASPFFKD TGLIEVEEKY GGSSSATSST 150
    AVGFDERMLL HSEFEVKAQP HPERPDRLRA IAASLATAGV FPGRCLPINA 200
    REITKQELQM VHTSEHVDAV DTTSQLLYSY FTSDTYANEY SARAARLAAG 250
    LCADLATDIF TGRVKNGFAL VRPPGHHAGV RHAMGFCLHN NAAVAALVAQ 300
    AAGAKKVLIV DWDVHHGNGT QEIFEQNKSV LYISLHRHEG GNFYPGTGAA 350
    DEVGSNGGEG YCVNVPWSCG GVGDKDYIFA FQHVVLPIAS AFSPDFVIIS 400
    AGFDAARGDP LGCCDVTPAG YSRMTQMLGD LCGGKMLVIL EGGYNLRSIS 450
    ASATAVIKVL LGENPENELP IATTPSVAGL QTVLDVLNIQ LEFWPSLAIS 500
    YSKLLSELEA RLIENKKNQM KRKVVRVPTW WKWGRKKLLY NFLSARMISR 550
    SK 552
    Length:552
    Mass (Da):60,020
    Last modified:November 16, 2011 - v2
    Checksum:i08BC902FCC99B886
    GO

    Sequence cautioni

    The sequence BAB01118.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti172 – 1721P → T in AAM63340. 1 PublicationCurated
    Sequence conflicti253 – 2531A → T in BAC42833. (PubMed:11910074)Curated
    Sequence conflicti342 – 3421N → I in BAC42833. (PubMed:11910074)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026658 Genomic DNA. Translation: BAB01118.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE76110.1.
    AK118211 mRNA. Translation: BAC42833.1.
    AY086135 mRNA. Translation: AAM63340.1.
    RefSeqiNP_566612.1. NM_112737.2. [Q8GXJ1-1]
    UniGeneiAt.38541.

    Genome annotation databases

    EnsemblPlantsiAT3G18520.1; AT3G18520.1; AT3G18520. [Q8GXJ1-1]
    GeneIDi821382.
    KEGGiath:AT3G18520.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026658 Genomic DNA. Translation: BAB01118.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE76110.1 .
    AK118211 mRNA. Translation: BAC42833.1 .
    AY086135 mRNA. Translation: AAM63340.1 .
    RefSeqi NP_566612.1. NM_112737.2. [Q8GXJ1-1 ]
    UniGenei At.38541.

    3D structure databases

    ProteinModelPortali Q8GXJ1.
    SMRi Q8GXJ1. Positions 149-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 6715. 3 interactions.

    Proteomic databases

    PaxDbi Q8GXJ1.
    PRIDEi Q8GXJ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G18520.1 ; AT3G18520.1 ; AT3G18520 . [Q8GXJ1-1 ]
    GeneIDi 821382.
    KEGGi ath:AT3G18520.

    Organism-specific databases

    TAIRi AT3G18520.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000225183.
    InParanoidi Q8GXJ1.
    KOi K11407.

    Enzyme and pathway databases

    BioCyci ARA:AT3G18520-MONOMER.
    ARA:GQT-826-MONOMER.

    Gene expression databases

    Genevestigatori Q8GXJ1.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR001876. Znf_RanBP2.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    PROSITEi PS01358. ZF_RANBP2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiHDA15_ARATH
    AccessioniPrimary (citable) accession number: Q8GXJ1
    Secondary accession number(s): F4J8S2
    , Q3EB46, Q8LD93, Q9LS38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 6, 2007
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3