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Q8GXJ1

- HDA15_ARATH

UniProt

Q8GXJ1 - HDA15_ARATH

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Protein

Histone deacetylase 15

Gene

HDA15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei277 – 2771By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri86 – 11530RanBP2-typeAdd
BLAST

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G18520-MONOMER.
ARA:GQT-826-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 15 (EC:3.5.1.98)
Gene namesi
Name:HDA15
Ordered Locus Names:At3g18520
ORF Names:MYF24_23
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G18520.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Histone deacetylase 15PRO_0000280091Add
BLAST

Proteomic databases

PaxDbiQ8GXJ1.
PRIDEiQ8GXJ1.

Expressioni

Gene expression databases

ExpressionAtlasiQ8GXJ1. baseline and differential.
GenevestigatoriQ8GXJ1.

Interactioni

Protein-protein interaction databases

BioGridi6715. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8GXJ1.
SMRiQ8GXJ1. Positions 149-497.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni149 – 462314Histone deacetylaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi58 – 7720Asp-richAdd
BLAST

Sequence similaritiesi

Contains 1 RanBP2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri86 – 11530RanBP2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000225183.
InParanoidiQ8GXJ1.
KOiK11407.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q8GXJ1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVVETIERSC EGSKRRHVNG GDIAVPCSGE ECSNGDINVA PGVSAKRARV
60 70 80 90 100
SREMTFEDIY GADALLNDDD DEDDDCDWEP VQAPMEFVKW CCVNCTMSNP
110 120 130 140 150
GDMVHCCICG EHKESGILRH GYLASPFFKD TGLIEVEEKY GGSSSATSST
160 170 180 190 200
AVGFDERMLL HSEFEVKAQP HPERPDRLRA IAASLATAGV FPGRCLPINA
210 220 230 240 250
REITKQELQM VHTSEHVDAV DTTSQLLYSY FTSDTYANEY SARAARLAAG
260 270 280 290 300
LCADLATDIF TGRVKNGFAL VRPPGHHAGV RHAMGFCLHN NAAVAALVAQ
310 320 330 340 350
AAGAKKVLIV DWDVHHGNGT QEIFEQNKSV LYISLHRHEG GNFYPGTGAA
360 370 380 390 400
DEVGSNGGEG YCVNVPWSCG GVGDKDYIFA FQHVVLPIAS AFSPDFVIIS
410 420 430 440 450
AGFDAARGDP LGCCDVTPAG YSRMTQMLGD LCGGKMLVIL EGGYNLRSIS
460 470 480 490 500
ASATAVIKVL LGENPENELP IATTPSVAGL QTVLDVLNIQ LEFWPSLAIS
510 520 530 540 550
YSKLLSELEA RLIENKKNQM KRKVVRVPTW WKWGRKKLLY NFLSARMISR

SK
Length:552
Mass (Da):60,020
Last modified:November 16, 2011 - v2
Checksum:i08BC902FCC99B886
GO

Sequence cautioni

The sequence BAB01118.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721P → T in AAM63340. 1 PublicationCurated
Sequence conflicti253 – 2531A → T in BAC42833. (PubMed:11910074)Curated
Sequence conflicti342 – 3421N → I in BAC42833. (PubMed:11910074)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026658 Genomic DNA. Translation: BAB01118.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE76110.1.
AK118211 mRNA. Translation: BAC42833.1.
AY086135 mRNA. Translation: AAM63340.1.
RefSeqiNP_566612.1. NM_112737.2. [Q8GXJ1-1]
UniGeneiAt.38541.

Genome annotation databases

EnsemblPlantsiAT3G18520.1; AT3G18520.1; AT3G18520. [Q8GXJ1-1]
GeneIDi821382.
KEGGiath:AT3G18520.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026658 Genomic DNA. Translation: BAB01118.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE76110.1 .
AK118211 mRNA. Translation: BAC42833.1 .
AY086135 mRNA. Translation: AAM63340.1 .
RefSeqi NP_566612.1. NM_112737.2. [Q8GXJ1-1 ]
UniGenei At.38541.

3D structure databases

ProteinModelPortali Q8GXJ1.
SMRi Q8GXJ1. Positions 149-497.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 6715. 3 interactions.

Proteomic databases

PaxDbi Q8GXJ1.
PRIDEi Q8GXJ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G18520.1 ; AT3G18520.1 ; AT3G18520 . [Q8GXJ1-1 ]
GeneIDi 821382.
KEGGi ath:AT3G18520.

Organism-specific databases

TAIRi AT3G18520.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000225183.
InParanoidi Q8GXJ1.
KOi K11407.

Enzyme and pathway databases

BioCyci ARA:AT3G18520-MONOMER.
ARA:GQT-826-MONOMER.

Gene expression databases

ExpressionAtlasi Q8GXJ1. baseline and differential.
Genevestigatori Q8GXJ1.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR001876. Znf_RanBP2.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
PROSITEi PS01358. ZF_RANBP2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiHDA15_ARATH
AccessioniPrimary (citable) accession number: Q8GXJ1
Secondary accession number(s): F4J8S2
, Q3EB46, Q8LD93, Q9LS38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3