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Protein

Phosphoinositide phospholipase C 6

Gene

PLC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152PROSITE-ProRule annotation1
Active sitei198PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT2G40116-MONOMER
BRENDAi3.1.4.11 399
ReactomeiR-ATH-112043 PLC beta mediated events
R-ATH-114604 GPVI-mediated activation cascade
R-ATH-1855204 Synthesis of IP3 and IP4 in the cytosol
R-ATH-202433 Generation of second messenger molecules
R-ATH-399997 Acetylcholine regulates insulin secretion
R-ATH-416476 G alpha (q) signalling events
R-ATH-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-ATH-5607764 CLEC7A (Dectin-1) signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase C 6 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase PLC6
Short name:
AtPLC6
Short name:
AtPLC8
Short name:
PI-PLC6
Gene namesi
Name:PLC6
Synonyms:PLC8
Ordered Locus Names:At2g40116
ORF Names:F27I1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G40116
TAIRilocus:504956034 AT2G40116

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241311 – 613Phosphoinositide phospholipase C 6Add BLAST613

Proteomic databases

PaxDbiQ8GV43
PRIDEiQ8GV43

Expressioni

Tissue specificityi

Expressed in leaves, flowers and siliques, but not in roots.1 Publication

Gene expression databases

ExpressionAtlasiQ8GV43 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G40116.1

Structurei

3D structure databases

ProteinModelPortaliQ8GV43
SMRiQ8GV43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini137 – 281PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST145
Domaini349 – 465PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini471 – 578C2PROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 71Gly-richAdd BLAST22

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
HOGENOMiHOG000244119
InParanoidiQ8GV43
KOiK05857
OMAiAVIVEYH
OrthoDBiEOG0936050V
PhylomeDBiQ8GV43

Family and domain databases

Gene3Di2.60.40.150, 1 hit
3.20.20.190, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q8GV43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEKKTESY NNDSGSYNYR MFKFYNRKFK INEVTPTDDV RDAFCQFAVG
60 70 80 90 100
GGGGGTDGDS SDGDGSTGVM GAEQLCSFLD DHGESTTVAE AQRLIDEVIR
110 120 130 140 150
RRHHVTRFTR HGLDLDDFFN FLFYDDLNPP ITPHVHQDMT APLSHYFIYT
160 170 180 190 200
GHNSYLTGNQ LSSDCSEVPV IKALQRGVRV IELDLWPNST GTDINVLHGR
210 220 230 240 250
TLTTPVPLMK CLKSIRDYAF SSSPYPVIIT LEDHLTPDLQ AKVAEMATQI
260 270 280 290 300
FGQMLYYPES DSLLEFPSPA SLLHRIIIST KPPKEYLESR NPIVKQKDNN
310 320 330 340 350
VSPSSEDETP RTEEIQTLES MLFDQDFESK SDSDQEDEEA SEDQKPAYKR
360 370 380 390 400
LITIHAGKPK GTVKEEMKVV VDKVRRLSLS EQELDRTCSS NSQDVVRFTQ
410 420 430 440 450
RNLLRIYPKG TRFNSSNYKP LIGWTHGAQM IAFNMQGYGK SLWLMHGMFR
460 470 480 490 500
ANGGCGYVKK PNFLMKKGFH DEVFDPRKKL PVKETLKVKV YMGDGWRMDF
510 520 530 540 550
SHTHFDAYSP PDFYTKMFIV GVPADNAKKK TKIIEDNWYP IWDEEFSFPL
560 570 580 590 600
TVPELALLRI EVREYDMSEK DDFGGQTCLP VAELRPGIRS VPLYDKKGEK
610
MKSVRLLMRF IFE
Length:613
Mass (Da):70,038
Last modified:March 18, 2008 - v2
Checksum:iF248C0B821903E6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002685 Genomic DNA Translation: AEC09783.1
BX819512 mRNA No translation available.
AY150803 Genomic DNA Translation: AAN75042.1
RefSeqiNP_850327.2, NM_179996.3

Genome annotation databases

EnsemblPlantsiAT2G40116.1; AT2G40116.1; AT2G40116
GeneIDi818602
GrameneiAT2G40116.1; AT2G40116.1; AT2G40116
KEGGiath:AT2G40116

Similar proteinsi

Entry informationi

Entry nameiPLCD6_ARATH
AccessioniPrimary (citable) accession number: Q8GV43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: April 25, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health