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Q8GV43

- PLCD6_ARATH

UniProt

Q8GV43 - PLCD6_ARATH

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Protein

Phosphoinositide phospholipase C 6

Gene

PLC6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei152 – 1521PROSITE-ProRule annotation
Active sitei198 – 1981PROSITE-ProRule annotation

GO - Molecular functioni

  1. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT2G40116-MONOMER.
ReactomeiREACT_187614. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase C 6 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase PLC6
Short name:
AtPLC6
Short name:
AtPLC8
Short name:
PI-PLC6
Gene namesi
Name:PLC6
Synonyms:PLC8
Ordered Locus Names:At2g40116
ORF Names:F27I1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G40116.

Subcellular locationi

Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613Phosphoinositide phospholipase C 6PRO_0000324131Add
BLAST

Proteomic databases

PaxDbiQ8GV43.
PRIDEiQ8GV43.

Expressioni

Tissue specificityi

Expressed in leaves, flowers and siliques, but not in roots.1 Publication

Gene expression databases

GenevestigatoriQ8GV43.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G40116.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8GV43.
SMRiQ8GV43. Positions 65-609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini137 – 281145PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST
Domaini349 – 465117PI-PLC Y-boxPROSITE-ProRule annotationAdd
BLAST
Domaini471 – 578108C2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 7122Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG149692.
HOGENOMiHOG000244119.
InParanoidiQ8GV43.
KOiK05857.
OMAiRDYAFSS.
PhylomeDBiQ8GV43.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8GV43-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKEKKTESY NNDSGSYNYR MFKFYNRKFK INEVTPTDDV RDAFCQFAVG
60 70 80 90 100
GGGGGTDGDS SDGDGSTGVM GAEQLCSFLD DHGESTTVAE AQRLIDEVIR
110 120 130 140 150
RRHHVTRFTR HGLDLDDFFN FLFYDDLNPP ITPHVHQDMT APLSHYFIYT
160 170 180 190 200
GHNSYLTGNQ LSSDCSEVPV IKALQRGVRV IELDLWPNST GTDINVLHGR
210 220 230 240 250
TLTTPVPLMK CLKSIRDYAF SSSPYPVIIT LEDHLTPDLQ AKVAEMATQI
260 270 280 290 300
FGQMLYYPES DSLLEFPSPA SLLHRIIIST KPPKEYLESR NPIVKQKDNN
310 320 330 340 350
VSPSSEDETP RTEEIQTLES MLFDQDFESK SDSDQEDEEA SEDQKPAYKR
360 370 380 390 400
LITIHAGKPK GTVKEEMKVV VDKVRRLSLS EQELDRTCSS NSQDVVRFTQ
410 420 430 440 450
RNLLRIYPKG TRFNSSNYKP LIGWTHGAQM IAFNMQGYGK SLWLMHGMFR
460 470 480 490 500
ANGGCGYVKK PNFLMKKGFH DEVFDPRKKL PVKETLKVKV YMGDGWRMDF
510 520 530 540 550
SHTHFDAYSP PDFYTKMFIV GVPADNAKKK TKIIEDNWYP IWDEEFSFPL
560 570 580 590 600
TVPELALLRI EVREYDMSEK DDFGGQTCLP VAELRPGIRS VPLYDKKGEK
610
MKSVRLLMRF IFE
Length:613
Mass (Da):70,038
Last modified:March 18, 2008 - v2
Checksum:iF248C0B821903E6D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002685 Genomic DNA. Translation: AEC09783.1.
BX819512 mRNA. No translation available.
AY150803 Genomic DNA. Translation: AAN75042.1.
RefSeqiNP_850327.2. NM_179996.2.
UniGeneiAt.50126.

Genome annotation databases

EnsemblPlantsiAT2G40116.1; AT2G40116.1; AT2G40116.
GeneIDi818602.
KEGGiath:AT2G40116.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002685 Genomic DNA. Translation: AEC09783.1 .
BX819512 mRNA. No translation available.
AY150803 Genomic DNA. Translation: AAN75042.1 .
RefSeqi NP_850327.2. NM_179996.2.
UniGenei At.50126.

3D structure databases

ProteinModelPortali Q8GV43.
SMRi Q8GV43. Positions 65-609.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT2G40116.1-P.

Proteomic databases

PaxDbi Q8GV43.
PRIDEi Q8GV43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G40116.1 ; AT2G40116.1 ; AT2G40116 .
GeneIDi 818602.
KEGGi ath:AT2G40116.

Organism-specific databases

TAIRi AT2G40116.

Phylogenomic databases

eggNOGi NOG149692.
HOGENOMi HOG000244119.
InParanoidi Q8GV43.
KOi K05857.
OMAi RDYAFSS.
PhylomeDBi Q8GV43.

Enzyme and pathway databases

BioCyci ARA:AT2G40116-MONOMER.
Reactomei REACT_187614. Synthesis of IP3 and IP4 in the cytosol.

Gene expression databases

Genevestigatori Q8GV43.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
Pfami PF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis thaliana phosphoinositide-specific phospholipase C 8 (AtPLC8)."
    Tasma I.M., Brendel V., Bhattacharyya M.K.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 70-613.
  5. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Gene-specific expression and calcium activation of Arabidopsis thaliana phospholipase C isoforms."
    Hunt L., Otterhag L., Lee J.C., Lasheen T., Hunt J., Seki M., Shinozaki K., Sommarin M., Gilmour D.J., Pical C., Gray J.E.
    New Phytol. 162:643-654(2004)
    [AGRICOLA] [Europe PMC]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPLCD6_ARATH
AccessioniPrimary (citable) accession number: Q8GV43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3