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Protein

Heat shock 70 kDa protein 9, mitochondrial

Gene

HSP70-9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: TAIR
  • unfolded protein binding Source: InterPro
  • zinc ion binding Source: TAIR

GO - Biological processi

  • protein folding Source: InterPro
  • response to cadmium ion Source: TAIR
  • response to cytokinin Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-3371453 Regulation of HSF1-mediated heat shock response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 9, mitochondrial
Alternative name(s):
Heat shock protein 70-9
Short name:
AtHsp70-9
Mitochondrial heat shock protein 70-1
Short name:
mtHsc70-1
Gene namesi
Name:HSP70-9
Synonyms:MTHSC70-1
Ordered Locus Names:At4g37910
ORF Names:F20D10.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G37910
TAIRilocus:2121022 AT4G37910

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46Mitochondrion1 PublicationAdd BLAST46
ChainiPRO_000041542847 – 682Heat shock 70 kDa protein 9, mitochondrialAdd BLAST636

Proteomic databases

PaxDbiQ8GUM2
PRIDEiQ8GUM2

PTM databases

iPTMnetiQ8GUM2
SwissPalmiQ8GUM2

Expressioni

Gene expression databases

ExpressionAtlasiQ8GUM2 baseline and differential
GenevisibleiQ8GUM2 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi15228, 1 interactor
IntActiQ8GUM2, 1 interactor
MINTiQ8GUM2
STRINGi3702.AT4G37910.1

Structurei

3D structure databases

ProteinModelPortaliQ8GUM2
SMRiQ8GUM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0102 Eukaryota
COG0443 LUCA
HOGENOMiHOG000228135
InParanoidiQ8GUM2
KOiK04043
OMAiYLARPFC
OrthoDBiEOG093604Y4
PhylomeDBiQ8GUM2

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
2.60.34.10, 1 hit
HAMAPiMF_00332 DnaK, 1 hit
InterProiView protein in InterPro
IPR012725 Chaperone_DnaK
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR029047 HSP70_peptide-bd_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100920 SSF100920, 1 hit
TIGRFAMsiTIGR02350 prok_dnaK, 1 hit
PROSITEiView protein in PROSITE
PS00297 HSP70_1, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8GUM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVALLRSF RRREVQMASV SAFKSVSANG KNSMFGKLGY LARPFCSRPV
60 70 80 90 100
GNDVIGIDLG TTNSCVSVME GKTARVIENA EGSRTTPSVV AMNQKGELLV
110 120 130 140 150
GTPAKRQAVT NPTNTIFGSK RLIGRRFDDP QTQKEMKMVP YKIVKAPNGD
160 170 180 190 200
AWVEANGQKF SPSQIGANVL TKMKETAEAY LGKSINKAVV TVPAYFNDAQ
210 220 230 240 250
RQATKDAGKI AGLDVQRIIN EPTAAALSYG MNNKEGVIAV FDLGGGTFDV
260 270 280 290 300
SILEISSGVF EVKATNGDTF LGGEDFDNTL LEYLVNEFKR SDNIDLTKDN
310 320 330 340 350
LALQRLREAA EKAKIELSST TQTEINLPFI TADASGAKHL NITLTRSKFE
360 370 380 390 400
GLVGKLIERT RSPCQNCLKD AGVTIKEVDE VLLVGGMTRV PKVQEIVSEI
410 420 430 440 450
FGKSPCKGVN PDEAVAMGAA IQGGILRGDV KDLLLLDVVP LSLGIETLGA
460 470 480 490 500
VFTKLIPRNT TIPTKKSQVF STAADNQMQV GIKVLQGERE MAADNKVLGE
510 520 530 540 550
FDLVGIPPAP RGMPQIEVTF DIDANGITTV SAKDKATGKE QNITIRSSGG
560 570 580 590 600
LSDDEINRMV KEAELNAQKD QEKKQLIDLR NSADTTIYSV EKSLSEYREK
610 620 630 640 650
IPAEIASEIE TAVSDLRTAM AGEDVEDIKA KVEAANKAVS KIGEHMSKGS
660 670 680
GSSGSDGSSG EGTSGTEQTP EAEFEEASGS RK
Length:682
Mass (Da):73,075
Last modified:March 1, 2003 - v1
Checksum:iBE8EC435202E7234
GO

Sequence cautioni

The sequence CAB37531 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB80456 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti414A → V in BAD94381 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035538 Genomic DNA Translation: CAB37531.1 Different initiation.
AL161592 Genomic DNA Translation: CAB80456.1 Different initiation.
CP002687 Genomic DNA Translation: AEE86852.1
CP002687 Genomic DNA Translation: ANM66081.1
BT002390 mRNA Translation: AAO00750.1
BT008430 mRNA Translation: AAP37789.1
AK221937 mRNA Translation: BAD94381.1
PIRiT05618
RefSeqiNP_001328002.1, NM_001342461.1
NP_195504.2, NM_119952.4
UniGeneiAt.2734

Genome annotation databases

EnsemblPlantsiAT4G37910.1; AT4G37910.1; AT4G37910
AT4G37910.2; AT4G37910.2; AT4G37910
GeneIDi829947
GrameneiAT4G37910.1; AT4G37910.1; AT4G37910
AT4G37910.2; AT4G37910.2; AT4G37910
KEGGiath:AT4G37910

Similar proteinsi

Entry informationi

Entry nameiHSP7I_ARATH
AccessioniPrimary (citable) accession number: Q8GUM2
Secondary accession number(s): Q56WU4, Q9SZJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health