Reviewed, UniProtKB/Swiss-Prot Q8GU87 (PDR6_ORYSJ)

Names and origin

Protein names

Recommended name:
    Pleiotropic drug resistance protein 6

Gene names

Name:	PDR6
Ordered Locus Names:	Os01g0177900, LOC_Os01g08260

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	1450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May be a general defense protein By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. [View classification] Contains 2 ABC transmembrane type-2 domains. Contains 2 ABC transporter domains.
Sequence caution	The sequence CAD59571.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8GU87-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8GU87-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1119-1142: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1450	1450	Pleiotropic drug resistance protein 6		PRO_0000234648
Regions
	Transmembrane	522 – 542	21	Potential
	Transmembrane	555 – 575	21	Potential
	Transmembrane	610 – 630	21	Potential
	Transmembrane	642 – 662	21	Potential
	Transmembrane	667 – 687	21	Potential
	Transmembrane	754 – 774	21	Potential
	Transmembrane	1192 – 1212	21	Potential
	Transmembrane	1220 – 1240	21	Potential
	Transmembrane	1278 – 1298	21	Potential
	Transmembrane	1305 – 1325	21	Potential
	Transmembrane	1335 – 1355	21	Potential
	Transmembrane	1362 – 1382	21	Potential
	Transmembrane	1414 – 1434	21	Potential
	Domain	154 – 426	273	ABC transporter 1
	Domain	504 – 717	214	ABC transmembrane type-2 1
	Domain	846 – 1098	253	ABC transporter 2
	Domain	1171 – 1385	215	ABC transmembrane type-2 2
	Nucleotide binding	187 – 194	8	ATP 1 Potential
	Nucleotide binding	891 – 898	8	ATP 2 Potential
Natural variations
	Alternative sequence	1119 – 1142	24	Missing in isoform 2.		VSP_018393
Experimental info
	Sequence conflict	1203	1	I → F Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 16, 2006. Version 2. Checksum: FEC331B707CC7D1C	FASTA	1,450	164,571
	10 20 30 40 50 60 MWAAEAAFAR SGSWREEEDE QEALRWAALQ RLPTVARARR GLLRSPAPGE DRVQGDDALC 70 80 90 100 110 120 EVDVAGLSPG DRTALVDRLL ADSGDVEDFF RRIRSRFDAV QIEFPKIEVR YEDLTVDAYV 130 140 150 160 170 180 HVGSRALPTI PNFICNMTEA FLRHLRIYRG GRVKLPILDN VSGIIRPSRM TLLLGPPSSG 190 200 210 220 230 240 KTTLLLALAG RLGPGLKVSG NITYNGHHLN EFVPQRTSAY VSQQDWHASE MTVRETLEFA 250 260 270 280 290 300 GRCQGVGIKY DMLVELLRRE KNEGIKPDED LDVFMKALAL EGKQTSLVAE YIMKVYGLDI 310 320 330 340 350 360 CADTIVGDEM IKGISGGQKK RLTTGELLVG SARVLFMDEI STGLDSATTY QIIKYLRHST 370 380 390 400 410 420 HALDGTTIIS LLQPAPETYE LFDDVILISE GQIVYQGPRE YAVDFFAGMG FRCPERKNVA 430 440 450 460 470 480 DFLQEVLSKK DQQQYWCHYD YPYQYVSVSK FAEAFKTFVI GKRLHDELAV PYNRHRNHPA 490 500 510 520 530 540 ALSTSNYGVR RLELLKSNFQ WQHLLMKRNS FIYVFKFIQL LLVALITMTV FFRSTMHRDS 550 560 570 580 590 600 VDDGIIYLGA LYFAIVMILF NGFTEVSLLV TKLPILYKHR DLHFYPPWAY TLPSWLLSIP 610 620 630 640 650 660 TSLIESGMWV LVTYYVVGYD PQFTRCLGQF LLLFFLHQTS LALFRVMASL GRNMIVANTF 670 680 690 700 710 720 GSFALLVVMI LGGFIITKES IPAWWIWGYW ISPMMYAQNA ISVNEFLGHS WSQQFANQNI 730 740 750 760 770 780 TLGEAILTGY GLFKEKYWFW IGVGALFGYA IVLNFLFTLF LTLLNPIGNI QAVVSKDDIQ 790 800 810 820 830 840 HRAPRRKNGK LALELRSYLH SASLNGHNLK DQKGMVLPFQ PLSMCFKNIN YYVDVPAELK 850 860 870 880 890 900 SQGIVEDRLQ LLIDVTGAFR PGILTALVGV SGAGKTTLMD VLAGRKTGGL IEGSITISGY 910 920 930 940 950 960 PKNQETFTRI SGYCEQNDVH SPCLTVIESL LYSACLRLPS HVDVNTRRVF VEEVMELVEL 970 980 990 1000 1010 1020 NALSGALVGL PGVNGLSTEQ RKRLTIAVEL VANPSIVFMD EPTSGLDARS AAIVMRTVRN 1030 1040 1050 1060 1070 1080 IVNTGRTIVC TIHQPSIDIF ESFDELLFMK RGGQLIYAGP LGSKSRNLVE FFEAIPGVPK 1090 1100 1110 1120 1130 1140 IRDGYNPAAW MLEVTSTQME QILGVDFAEY YRQSKLFQTQ RPFSPLILVS FSLNMFMLWH 1150 1160 1170 1180 1190 1200 SRQTQEMVDI LSRPRRESKE LTFATKYSQP FFAQYAACLW KQNLSYWRNP QYTAVRFFYT 1210 1220 1230 1240 1250 1260 VIISLMFGTI CWKFGSRRET QHDIFNAMGA MYAAVLFIGI TNATSVQPVI SIERFVSYRE 1270 1280 1290 1300 1310 1320 RAAGMYSALP FAFSLVTVEF PYILVQSLIY GTIFYSLGSF EWTAVKFLWY LFFMYFTLLY 1330 1340 1350 1360 1370 1380 FTFYGMMTTA ITPNHTVAPI IAAPFYTLWN LFCGFMIPRK RIPAWWRWYY WANPVSWTLY 1390 1400 1410 1420 1430 1440 GLLTSQFGDL DQPLLLADGI TTTTAVDFLR DHFGFRHDFL GVVAGMVAGF CVLFAVVFAL 1450 AIKYLNFQRR
	Isoform 2. Checksum: DD818A60BF1C7E0C	FASTA	1,426	161,680
	10 20 30 40 50 60 MWAAEAAFAR SGSWREEEDE QEALRWAALQ RLPTVARARR GLLRSPAPGE DRVQGDDALC 70 80 90 100 110 120 EVDVAGLSPG DRTALVDRLL ADSGDVEDFF RRIRSRFDAV QIEFPKIEVR YEDLTVDAYV 130 140 150 160 170 180 HVGSRALPTI PNFICNMTEA FLRHLRIYRG GRVKLPILDN VSGIIRPSRM TLLLGPPSSG 190 200 210 220 230 240 KTTLLLALAG RLGPGLKVSG NITYNGHHLN EFVPQRTSAY VSQQDWHASE MTVRETLEFA 250 260 270 280 290 300 GRCQGVGIKY DMLVELLRRE KNEGIKPDED LDVFMKALAL EGKQTSLVAE YIMKVYGLDI 310 320 330 340 350 360 CADTIVGDEM IKGISGGQKK RLTTGELLVG SARVLFMDEI STGLDSATTY QIIKYLRHST 370 380 390 400 410 420 HALDGTTIIS LLQPAPETYE LFDDVILISE GQIVYQGPRE YAVDFFAGMG FRCPERKNVA 430 440 450 460 470 480 DFLQEVLSKK DQQQYWCHYD YPYQYVSVSK FAEAFKTFVI GKRLHDELAV PYNRHRNHPA 490 500 510 520 530 540 ALSTSNYGVR RLELLKSNFQ WQHLLMKRNS FIYVFKFIQL LLVALITMTV FFRSTMHRDS 550 560 570 580 590 600 VDDGIIYLGA LYFAIVMILF NGFTEVSLLV TKLPILYKHR DLHFYPPWAY TLPSWLLSIP 610 620 630 640 650 660 TSLIESGMWV LVTYYVVGYD PQFTRCLGQF LLLFFLHQTS LALFRVMASL GRNMIVANTF 670 680 690 700 710 720 GSFALLVVMI LGGFIITKES IPAWWIWGYW ISPMMYAQNA ISVNEFLGHS WSQQFANQNI 730 740 750 760 770 780 TLGEAILTGY GLFKEKYWFW IGVGALFGYA IVLNFLFTLF LTLLNPIGNI QAVVSKDDIQ 790 800 810 820 830 840 HRAPRRKNGK LALELRSYLH SASLNGHNLK DQKGMVLPFQ PLSMCFKNIN YYVDVPAELK 850 860 870 880 890 900 SQGIVEDRLQ LLIDVTGAFR PGILTALVGV SGAGKTTLMD VLAGRKTGGL IEGSITISGY 910 920 930 940 950 960 PKNQETFTRI SGYCEQNDVH SPCLTVIESL LYSACLRLPS HVDVNTRRVF VEEVMELVEL 970 980 990 1000 1010 1020 NALSGALVGL PGVNGLSTEQ RKRLTIAVEL VANPSIVFMD EPTSGLDARS AAIVMRTVRN 1030 1040 1050 1060 1070 1080 IVNTGRTIVC TIHQPSIDIF ESFDELLFMK RGGQLIYAGP LGSKSRNLVE FFEAIPGVPK 1090 1100 1110 1120 1130 1140 IRDGYNPAAW MLEVTSTQME QILGVDFAEY YRQSKLFQQT QEMVDILSRP RRESKELTFA 1150 1160 1170 1180 1190 1200 TKYSQPFFAQ YAACLWKQNL SYWRNPQYTA VRFFYTVIIS LMFGTICWKF GSRRETQHDI 1210 1220 1230 1240 1250 1260 FNAMGAMYAA VLFIGITNAT SVQPVISIER FVSYRERAAG MYSALPFAFS LVTVEFPYIL 1270 1280 1290 1300 1310 1320 VQSLIYGTIF YSLGSFEWTA VKFLWYLFFM YFTLLYFTFY GMMTTAITPN HTVAPIIAAP 1330 1340 1350 1360 1370 1380 FYTLWNLFCG FMIPRKRIPA WWRWYYWANP VSWTLYGLLT SQFGDLDQPL LLADGITTTT 1390 1400 1410 1420 AVDFLRDHFG FRHDFLGVVA GMVAGFCVLF AVVFALAIKY LNFQRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ATP-binding cassette transporters: structure, function, and gene family comparison between rice and Arabidopsis." Jasinski M., Ducos E., Martinoia E., Boutry M. Plant Physiol. 131:1169-1177(2003) [PubMed: 12644668] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1056-1450 (ISOFORMS 1 AND 2). Strain: cv. Nipponbare.
[4]	"Organization and function of the plant pleiotropic drug resistance ABC transporter family." Crouzet J., Trombik T., Fraysse A.S., Boutry M. FEBS Lett. 580:1123-1130(2006) [PubMed: 16506311] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ535049 Genomic DNA. Translation: CAD59571.1. Sequence problems. AP002523 Genomic DNA. No translation available. AK058355 mRNA. No translation available. AK061474 mRNA. No translation available.
3D structure databases
ModBase	Search...
Organism-specific databases
Gramene	Q8GU87.
Family and domain databases
InterPro	IPR013525. ABC_2_trans. IPR003439. ABC_transporter-like. IPR003593. ATPase_AAA+_core. IPR013581. PDR_assoc. [Graphical view]
Pfam	PF01061. ABC2_membrane. 2 hits. PF00005. ABC_tran. 2 hits. PF08370. PDR_assoc. 1 hit. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS51012. ABC_TM2. False negative. PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PDR6_ORYSJ

Accession

Primary (citable) accession number: Q8GU87

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	May 16, 2006
Last modified:	November 24, 2009
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)