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Q8GSM3

- LOX22_HORVU

UniProt

Q8GSM3 - LOX22_HORVU

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Protein

Lipoxygenase 2.2, chloroplastic

Gene
LOX2.2
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This enzyme exhibits linoleate 13-lipoxygenase activity.

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Binds 1 iron ion per subunit. Iron is tightly bound By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi588 – 5881Iron; catalytic By similarity
Metal bindingi593 – 5931Iron; catalytic By similarity
Metal bindingi778 – 7781Iron; catalytic By similarity
Metal bindingi782 – 7821Iron; catalytic By similarity
Metal bindingi932 – 9321Iron; via carboxylate; catalytic By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. oxylipin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase 2.2, chloroplastic (EC:1.13.11.12)
Alternative name(s):
LOX2:Hv:2
Gene namesi
Name:LOX2.2
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiQ8GSM3.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 932Lipoxygenase 2.2, chloroplasticPRO_0000018324
Transit peptidei1 – ?Chloroplast Reviewed prediction

Expressioni

Gene expression databases

GenevestigatoriQ8GSM3.

Structurei

3D structure databases

ProteinModelPortaliQ8GSM3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 219141PLATAdd
BLAST
Domaini223 – 932710LipoxygenaseAdd
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.
Contains 1 PLAT domain.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8GSM3-1 [UniParc]FASTAAdd to Basket

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MQTATKPLVG ARAVPLSRRA SFLVAEARRK PSTNARRTRV GSTSTTTTTT    50
TILTDVNGPA LTTVAKPGHQ YDLKQTVEMK ATVSVHMKSF WWSDEKKERA 100
RDWAYDLILG SWLTLELVSS ELDPKTGQEH DVISGKLKHS RETEKDYDLY 150
EAIFTCRHRL APSGAVRLVN YHHTEMLLGE VKIFPAGEDP TKSSAVTLFH 200
CQSWIDPSHC SPDKRTFFPV EKSYIPSQTP KGVEKLRKSE LEALRGNGCG 250
ERKKHDRIYD YDVYNDLGKP ESKRPVLGGK EHPYPRRCRT GRPRSKTDPS 300
SEEESHKKGE MYVPRDETFT ERKEQAFLTK QLLSQLHGLC TGLKVNKDIL 350
PSFPTLASID ALYDDDFRNQ PVQPEGGKVR LILDLLAKEL VHLVKLEGAE 400
FVEGIRRVFK FETPEIHDMD KLAWFRDEEF ARQTLAGMNP LSIQLVTELP 450
IVSKLDELKY GPADSLITKE LIEKQINRIM TAEEAVAQKK LFMLDYHDLL 500
LPYVHRVRKL DNKTMYGSRT LFFLADDGTL RPIAIELTRP KSPHKQQWRK 550
VFTPGSGYSG SVTGSWEWQL AKIHVLSHDT GYHQLVSHWL RTHCCVEPYV 600
IAANRQLSQM HPIYRLLHPH FRFTMEINAQ ARGMLICADG IIEKTFSPGE 650
FSMEISSAAY DKQWRFDMEA LPEDLIRRGM AVRGEDGKLE LAIEDYPYAN 700
DGLLVWDAIK QWASDYVAHY YPCAVDIVDD EELQDWWTEV RTKGHPDKQD 750
EPWWPELDCH ESLVQVLATI MWVTSAHHAA VNFGQYPMAG YVPNHPSIAR 800
RNMPCEMGPE EMLAFKAAPE KVWLDTLPSQ LQTVMVMATL DLLSSHASDE 850
EYMGTHQEPA WQRDGEVDKA FQVFQKKMRD IAEQVEEWNK DDSRRNRHGA 900
GVVPYVLLRP LNGNPMDAKT VMEMGIPNSI SI 932
Length:932
Mass (Da):106,493
Last modified:March 1, 2003 - v1
Checksum:i64D80DF4370F30E0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ507212 mRNA. Translation: CAD45186.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ507212 mRNA. Translation: CAD45186.1 .

3D structure databases

ProteinModelPortali Q8GSM3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q8GSM3.

Enzyme and pathway databases

UniPathwayi UPA00382 .

Gene expression databases

Genevestigatori Q8GSM3.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of the chloroplast."
    Bachmann A., Hause B., Maucher H., Garbe E., Voeroes K., Weichert H., Wasternack C., Feussner I.
    Biol. Chem. 383:1645-1657(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: cv. Salome.
    Tissue: Leaf.

Entry informationi

Entry nameiLOX22_HORVU
AccessioniPrimary (citable) accession number: Q8GSM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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