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Protein

Lipoxygenase 2.2, chloroplastic

Gene

LOX2.2

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This enzyme exhibits linoleate 13-lipoxygenase activity.

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

Pathwayi: oxylipin biosynthesis

This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi588Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi593Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi778Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi782Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi932Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase 2.2, chloroplastic (EC:1.13.11.12)
Alternative name(s):
LOX2:Hv:2
Gene namesi
Name:LOX2.2
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000018324? – 932Lipoxygenase 2.2, chloroplastic
Transit peptidei1 – ?ChloroplastSequence analysis

Expressioni

Gene expression databases

ExpressionAtlasiQ8GSM3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ8GSM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 219PLATPROSITE-ProRule annotationAdd BLAST141
Domaini223 – 932LipoxygenasePROSITE-ProRule annotationAdd BLAST710

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IIW1 Eukaryota
ENOG410YN4N LUCA
KOiK00454

Family and domain databases

InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8GSM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTATKPLVG ARAVPLSRRA SFLVAEARRK PSTNARRTRV GSTSTTTTTT
60 70 80 90 100
TILTDVNGPA LTTVAKPGHQ YDLKQTVEMK ATVSVHMKSF WWSDEKKERA
110 120 130 140 150
RDWAYDLILG SWLTLELVSS ELDPKTGQEH DVISGKLKHS RETEKDYDLY
160 170 180 190 200
EAIFTCRHRL APSGAVRLVN YHHTEMLLGE VKIFPAGEDP TKSSAVTLFH
210 220 230 240 250
CQSWIDPSHC SPDKRTFFPV EKSYIPSQTP KGVEKLRKSE LEALRGNGCG
260 270 280 290 300
ERKKHDRIYD YDVYNDLGKP ESKRPVLGGK EHPYPRRCRT GRPRSKTDPS
310 320 330 340 350
SEEESHKKGE MYVPRDETFT ERKEQAFLTK QLLSQLHGLC TGLKVNKDIL
360 370 380 390 400
PSFPTLASID ALYDDDFRNQ PVQPEGGKVR LILDLLAKEL VHLVKLEGAE
410 420 430 440 450
FVEGIRRVFK FETPEIHDMD KLAWFRDEEF ARQTLAGMNP LSIQLVTELP
460 470 480 490 500
IVSKLDELKY GPADSLITKE LIEKQINRIM TAEEAVAQKK LFMLDYHDLL
510 520 530 540 550
LPYVHRVRKL DNKTMYGSRT LFFLADDGTL RPIAIELTRP KSPHKQQWRK
560 570 580 590 600
VFTPGSGYSG SVTGSWEWQL AKIHVLSHDT GYHQLVSHWL RTHCCVEPYV
610 620 630 640 650
IAANRQLSQM HPIYRLLHPH FRFTMEINAQ ARGMLICADG IIEKTFSPGE
660 670 680 690 700
FSMEISSAAY DKQWRFDMEA LPEDLIRRGM AVRGEDGKLE LAIEDYPYAN
710 720 730 740 750
DGLLVWDAIK QWASDYVAHY YPCAVDIVDD EELQDWWTEV RTKGHPDKQD
760 770 780 790 800
EPWWPELDCH ESLVQVLATI MWVTSAHHAA VNFGQYPMAG YVPNHPSIAR
810 820 830 840 850
RNMPCEMGPE EMLAFKAAPE KVWLDTLPSQ LQTVMVMATL DLLSSHASDE
860 870 880 890 900
EYMGTHQEPA WQRDGEVDKA FQVFQKKMRD IAEQVEEWNK DDSRRNRHGA
910 920 930
GVVPYVLLRP LNGNPMDAKT VMEMGIPNSI SI
Length:932
Mass (Da):106,493
Last modified:March 1, 2003 - v1
Checksum:i64D80DF4370F30E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ507212 mRNA Translation: CAD45186.1

Genome annotation databases

KEGGiag:CAD45186

Similar proteinsi

Entry informationi

Entry nameiLOX22_HORVU
AccessioniPrimary (citable) accession number: Q8GSM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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