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Q8GSM2

- LOX23_HORVU

UniProt

Q8GSM2 - LOX23_HORVU

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Protein
Lipoxygenase 2.3, chloroplastic
Gene
LOX2.3
Organism
Hordeum vulgare (Barley)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. This enzyme exhibits linoleate 13-lipoxygenase activity.

Catalytic activityi

Linoleate + O2 = (9Z,11E,13S)-13-hydroperoxyoctadeca-9,11-dienoate.
Alpha-linolenate + O2 = (9Z,11E,13S,15Z)-13-hydroperoxyoctadeca-9,11,15-trienoate.

Cofactori

Binds 1 iron ion per subunit. Iron is tightly bound By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi556 – 5561Iron; catalytic By similarity
Metal bindingi561 – 5611Iron; catalytic By similarity
Metal bindingi746 – 7461Iron; catalytic By similarity
Metal bindingi750 – 7501Iron; catalytic By similarity
Metal bindingi896 – 8961Iron; via carboxylate; catalytic By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. linoleate 13S-lipoxygenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid oxidation Source: EnsemblPlants/Gramene
  2. oxylipin biosynthetic process Source: UniProtKB-UniPathway
  3. response to bacterium Source: EnsemblPlants/Gramene
  4. response to fungus Source: EnsemblPlants/Gramene
  5. response to herbivore Source: EnsemblPlants/Gramene
  6. response to jasmonic acid Source: EnsemblPlants/Gramene
  7. response to wounding Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00382.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoxygenase 2.3, chloroplastic (EC:1.13.11.12)
Alternative name(s):
LOX2:Hv:3
Gene namesi
Name:LOX2.3
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladePooideaeTriticeaeHordeum

Organism-specific databases

GrameneiQ8GSM2.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast envelope Source: EnsemblPlants/Gramene
  2. chloroplast stroma Source: EnsemblPlants/Gramene
  3. chloroplast thylakoid membrane Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 896Lipoxygenase 2.3, chloroplasticPRO_0000018325
Transit peptidei1 – ?Chloroplast Reviewed prediction

Proteomic databases

PRIDEiQ8GSM2.

Expressioni

Gene expression databases

GenevestigatoriQ8GSM2.

Structurei

3D structure databases

ProteinModelPortaliQ8GSM2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 199120PLAT
Add
BLAST
Domaini202 – 896695Lipoxygenase
Add
BLAST

Sequence similaritiesi

Belongs to the lipoxygenase family.
Contains 1 PLAT domain.

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProiIPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view]
PANTHERiPTHR11771. PTHR11771. 1 hit.
PfamiPF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view]
PRINTSiPR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTiSM00308. LH2. 1 hit.
[Graphical view]
SUPFAMiSSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEiPS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8GSM2-1 [UniParc]FASTAAdd to Basket

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MIHLKQPLVL SAQSSNVASP LFVAGGQQRR ASGAGRTCSG RRLSARRISC    50
ASTEEAVGVS TSVTTKERAL TVTAIVTAQV PTSVYVARGL DDIQDLFGKT 100
LLLELVSSEL DPKTGRERER VKGFAHMTLK EGTYEAKMSV PASFGPVGAV 150
LVENEHHREM FIKDIKLITG GDESTAITFD VASWVHSKFD DPEPRAFFTV 200
KSYLPSQTPP GIEALRKKEL ETLRGDGHSE RKFHERVYDY DTYNDLGDPD 250
KNIDHKRPVL GTKEHPYPRR CRTGRPKTLY DPETETRSSP VYVPRDEQFS 300
DVKGRTFSAT TLRSGLHAIL PAVAPLLNNS HGFSHFPAID ALYSDGIPLP 350
VDGHGGNSFN VINDVIPRVV QMIEDTTEHV LRFEVPEMLE RDRFSWFRDE 400
EFARQTLAGL NPICIRRLTE FPIVSKLDPA VYGPAESALS KEILEKMMNG 450
RMTVEEAMEK KRLFLLDYHD VFLPYVHRVR ELPDTTLYGS RTVFFLSDEG 500
TLMPLAIELT RPQSPTKPQW KRAFTHGSDA TESWLWKLAK AHVLTHDTGY 550
HQLVSHWLRT HACVEPYIIA TNRQLSRMHP VYRLLHPHFR YTMEINALAR 600
EALINADGII EEAFLAGKYS IELSSVAYGA AWQFNTEALP EDLINRGLAV 650
RRDDGELELA IKDYPYADDG LLIWGSIKQW ASDYVDFYYK SDGDVAGDEE 700
LRAWWEEVRT KGHADKKDEP WWPVCDTKEN LVQILTIIMW VTSGHHAAVN 750
FGQYHYAGYF PNRPTVVRRN IPVEENRDDE MKKFMARPEE VLLQSLPSQM 800
QAIKVMATLD ILSSHSPDEE YMGEYAEPAW LAEPMVKAAF EKFSGRLKEA 850
EGTIDMRNNN PENKNRCGAG IVPYELLKPF SEPGVTGRGI PNSISI 896
Length:896
Mass (Da):101,234
Last modified:March 1, 2003 - v1
Checksum:i31511189946B866A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ507213 mRNA. Translation: CAD45187.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ507213 mRNA. Translation: CAD45187.1 .

3D structure databases

ProteinModelPortali Q8GSM2.
ModBasei Search...

Proteomic databases

PRIDEi Q8GSM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q8GSM2.

Enzyme and pathway databases

UniPathwayi UPA00382 .

Gene expression databases

Genevestigatori Q8GSM2.

Family and domain databases

Gene3Di 2.60.60.20. 1 hit.
4.10.372.10. 1 hit.
InterProi IPR008976. Lipase_LipOase.
IPR000907. LipOase.
IPR013819. LipOase_C.
IPR020834. LipOase_CS.
IPR020833. LipOase_Fe_BS.
IPR001246. LipOase_pln.
IPR027433. Lipoxygenase_domain_3.
IPR001024. PLAT/LH2_dom.
[Graphical view ]
PANTHERi PTHR11771. PTHR11771. 1 hit.
Pfami PF00305. Lipoxygenase. 1 hit.
PF01477. PLAT. 1 hit.
[Graphical view ]
PRINTSi PR00087. LIPOXYGENASE.
PR00468. PLTLPOXGNASE.
SMARTi SM00308. LH2. 1 hit.
[Graphical view ]
SUPFAMi SSF48484. SSF48484. 1 hit.
SSF49723. SSF49723. 1 hit.
PROSITEi PS00711. LIPOXYGENASE_1. 1 hit.
PS00081. LIPOXYGENASE_2. 1 hit.
PS51393. LIPOXYGENASE_3. 1 hit.
PS50095. PLAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Jasmonate-induced lipid peroxidation in barley leaves initiated by distinct 13-LOX forms of the chloroplast."
    Bachmann A., Hause B., Maucher H., Garbe E., Voeroes K., Weichert H., Wasternack C., Feussner I.
    Biol. Chem. 383:1645-1657(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: cv. Salome.
    Tissue: Leaf.

Entry informationi

Entry nameiLOX23_HORVU
AccessioniPrimary (citable) accession number: Q8GSM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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