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Protein

Calmodulin-binding transcription activator 3

Gene

CMTA3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates transcriptional activity in response to calcium signals. Binds to the consensus sequence 5'-[ACG]CGCG[GTC]-3'.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 141CG-1PROSITE-ProRule annotationAdd BLAST127

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • defense response to fungus Source: TAIR
  • leaf senescence Source: TAIR
  • positive regulation of transcription from RNA polymerase II promoter Source: GO_Central
  • regulation of transcription, DNA-templated Source: TAIR
  • response to cold Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

Calcium, Calmodulin-binding, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-binding transcription activator 3
Alternative name(s):
Ethylene-induced calmodulin-binding protein 1
Short name:
EICBP1
Ethylene-induced calmodulin-binding protein a
Short name:
EICBP.a
Signal-responsive protein 1
Gene namesi
Name:CMTA3
Synonyms:SR1
Ordered Locus Names:At2g22300
ORF Names:T26C19.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G22300.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001144881 – 1032Calmodulin-binding transcription activator 3Add BLAST1032

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei272PhosphoserineCombined sources1
Modified residuei964PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8GSA7.
PRIDEiQ8GSA7.

PTM databases

iPTMnetiQ8GSA7.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves, carpels, and siliques, but not in stigmas or other parts of the flower.3 Publications

Inductioni

By temperature, UVB, salt, wounding, ethylene and methyl jasmonate.2 Publications

Gene expression databases

GenevisibleiQ8GSA7. AT.

Interactioni

Subunit structurei

Binds to calmodulin.

Protein-protein interaction databases

BioGridi2115. 2 interactors.
DIPiDIP-59735N.
MINTiMINT-8064185.
STRINGi3702.AT2G22300.1.

Structurei

3D structure databases

ProteinModelPortaliQ8GSA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati661 – 690ANK 1Add BLAST30
Repeati694 – 723ANK 2Add BLAST30
Repeati733 – 762ANK 3Add BLAST30
Domaini852 – 881IQ 1PROSITE-ProRule annotationAdd BLAST30
Domaini875 – 904IQ 2PROSITE-ProRule annotationAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili945 – 987Sequence analysisAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi780 – 785Poly-Ser6
Compositional biasi1003 – 1019Asp-richAdd BLAST17

Sequence similaritiesi

Belongs to the CAMTA family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation
Contains 1 CG-1 DNA-binding domain.PROSITE-ProRule annotation
Contains 2 IQ domains.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IUMH. Eukaryota.
ENOG4112848. LUCA.
HOGENOMiHOG000240102.
InParanoidiQ8GSA7.
OMAiDETESAY.
OrthoDBiEOG0936043Z.
PhylomeDBiQ8GSA7.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
SM00015. IQ. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8GSA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARRFSPV HELDVGQILS EARHRWLRPP EICEILQNYQ RFQISTEPPT
60 70 80 90 100
TPSSGSVFMF DRKVLRYFRK DGHNWRKKKD GKTVKEAHER LKAGSVDVLH
110 120 130 140 150
CYYAHGQDNE NFQRRSYWLL QEELSHIVFV HYLEVKGSRV STSFNRMQRT
160 170 180 190 200
EDAARSPQET GDALTSEHDG YASCSFNQND HSNHSQTTDS ASVNGFHSPE
210 220 230 240 250
LEDAESAYNQ HGSSTAYSHQ ELQQPATGGN LTGFDPYYQI SLTPRDSYQK
260 270 280 290 300
ELRTIPVTDS SIMVDKSKTI NSPGVTNGLK NRKSIDSQTW EEILGNCGSG
310 320 330 340 350
VEALPLQPNS EHEVLDQILE SSFTMQDFAS LQESMVKSQN QELNSGLTSD
360 370 380 390 400
RTVWFQGQDM ELNAISNLAS NEKAPYLSTM KQHLLHGALG EEGLKKMDSF
410 420 430 440 450
NRWMSKELGD VGVIADANES FTQSSSRTYW EEVESEDGSN GHNSRRDMDG
460 470 480 490 500
YVMSPSLSKE QLFSINDFSP SWAYVGCEVV VFVTGKFLKT REETEIGEWS
510 520 530 540 550
CMFGQTEVPA DVISNGILQC VAPMHEAGRV PFYVTCSNRL ACSEVREFEY
560 570 580 590 600
KVAESQVFDR EADDESTIDI LEARFVKLLC SKSENTSPVS GNDSDLSQLS
610 620 630 640 650
EKISLLLFEN DDQLDQMLMN EISQENMKNN LLQEFLKESL HSWLLQKIAE
660 670 680 690 700
GGKGPSVLDE GGQGVLHFAA SLGYNWALEP TIIAGVSVDF RDVNGWTALH
710 720 730 740 750
WAAFFGRERI IGSLIALGAA PGTLTDPNPD FPSGSTPSDL AYANGHKGIA
760 770 780 790 800
GYLSEYALRA HVSLLSLNDK NAETVEMAPS PSSSSLTDSL TAVRNATQAA
810 820 830 840 850
ARIHQVFRAQ SFQKKQLKEF GDKKLGMSEE RALSMLAPKT HKSGRAHSDD
860 870 880 890 900
SVQAAAIRIQ NKFRGYKGRK DYLITRQRII KIQAHVRGYQ FRKNYRKIIW
910 920 930 940 950
SVGVLEKVIL RWRRKGAGLR GFKSEALVEK MQDGTEKEED DDFFKQGRKQ
960 970 980 990 1000
TEDRLQKALA RVKSMVQYPE ARDQYRRLLN VVNDIQESKV EKALENSEAT
1010 1020 1030
CFDDDDDLID IEALLEDDDT LMLPMSSSLW TS
Length:1,032
Mass (Da):116,111
Last modified:March 1, 2003 - v1
Checksum:i4C5E9775A3795862
GO

Sequence cautioni

The sequence AAD23613 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510025 mRNA. Translation: AAR98746.1.
AF303397 mRNA. Translation: AAG37879.1.
AF506697 mRNA. Translation: AAN74651.1.
AC007168 Genomic DNA. Translation: AAD23613.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC07289.1.
CP002685 Genomic DNA. Translation: AEC07290.1.
BT002459 mRNA. Translation: AAO00819.1.
PIRiA84611.
RefSeqiNP_001118361.1. NM_001124889.2.
NP_850023.1. NM_179692.3.
UniGeneiAt.48505.
At.71036.

Genome annotation databases

EnsemblPlantsiAT2G22300.1; AT2G22300.1; AT2G22300.
AT2G22300.2; AT2G22300.2; AT2G22300.
GeneIDi816762.
GrameneiAT2G22300.1; AT2G22300.1; AT2G22300.
AT2G22300.2; AT2G22300.2; AT2G22300.
KEGGiath:AT2G22300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510025 mRNA. Translation: AAR98746.1.
AF303397 mRNA. Translation: AAG37879.1.
AF506697 mRNA. Translation: AAN74651.1.
AC007168 Genomic DNA. Translation: AAD23613.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC07289.1.
CP002685 Genomic DNA. Translation: AEC07290.1.
BT002459 mRNA. Translation: AAO00819.1.
PIRiA84611.
RefSeqiNP_001118361.1. NM_001124889.2.
NP_850023.1. NM_179692.3.
UniGeneiAt.48505.
At.71036.

3D structure databases

ProteinModelPortaliQ8GSA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2115. 2 interactors.
DIPiDIP-59735N.
MINTiMINT-8064185.
STRINGi3702.AT2G22300.1.

PTM databases

iPTMnetiQ8GSA7.

Proteomic databases

PaxDbiQ8GSA7.
PRIDEiQ8GSA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G22300.1; AT2G22300.1; AT2G22300.
AT2G22300.2; AT2G22300.2; AT2G22300.
GeneIDi816762.
GrameneiAT2G22300.1; AT2G22300.1; AT2G22300.
AT2G22300.2; AT2G22300.2; AT2G22300.
KEGGiath:AT2G22300.

Organism-specific databases

TAIRiAT2G22300.

Phylogenomic databases

eggNOGiENOG410IUMH. Eukaryota.
ENOG4112848. LUCA.
HOGENOMiHOG000240102.
InParanoidiQ8GSA7.
OMAiDETESAY.
OrthoDBiEOG0936043Z.
PhylomeDBiQ8GSA7.

Miscellaneous databases

PROiQ8GSA7.

Gene expression databases

GenevisibleiQ8GSA7. AT.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005559. CG-1_dom.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR000048. IQ_motif_EF-hand-BS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03859. CG-1. 1 hit.
PF00612. IQ. 2 hits.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM01076. CG-1. 1 hit.
SM00015. IQ. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF81296. SSF81296. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS51437. CG_1. 1 hit.
PS50096. IQ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCMTA3_ARATH
AccessioniPrimary (citable) accession number: Q8GSA7
Secondary accession number(s): Q9FPR9, Q9SID7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.