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Protein
Submitted name:

Ancillary protein 1

Gene

cpa1

Organism
Streptococcus pyogenes
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Ancillary protein 1Imported
Submitted name:
Collagen binding proteinImported
Gene namesi
Name:cpa1Imported
OrganismiStreptococcus pyogenesImported
Taxonomic identifieri1314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4722HelicalSequence analysisAdd
BLAST
Transmembranei729 – 74820HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XI9X-ray1.90A/B286-723[»]
2XICX-ray2.90A/B286-723[»]
2XIDX-ray2.65A/B286-723[»]
4BUGX-ray2.80A/B285-723[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini71 – 278208TEDInterPro annotationAdd
BLAST
Domaini391 – 589199TEDInterPro annotationAdd
BLAST

Keywords - Domaini

CollagenImported, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

InterProiIPR023849. CHP03934_TQXA.
IPR013552. Thioester_dom.
[Graphical view]
PfamiPF08341. TED. 2 hits.
[Graphical view]
TIGRFAMsiTIGR03934. TQXA_dom. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8GRA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKTRFPNKL NTLNTQRVLS KNSKRFTVTL VGVFLMIFAL VTSMVGAKTV
60 70 80 90 100
FGLVESSTPN AINPDSSSEY RWYGYESYVR GHPYYKQFRV AHDLRVNLEG
110 120 130 140 150
SRSYQVYCFN LKKAFPLGSD SSVKKWYKKH DGISTKFEDY AISPRITGDE
160 170 180 190 200
LNQKLRAVMY NGHPQNANGI MEGLEPLNAI RVTQEAVWYY SDNAPISNPD
210 220 230 240 250
ESFKRESESN LVSTSQLSLM RQALKQLIDP NLATKMPKQV PDDFQLSIFE
260 270 280 290 300
SEDKGDKYNK GYQNLLSGGL VPTKPPTPGD PPMPPNQPQT TSVLIRKYAI
310 320 330 340 350
GDYSKLLEGA TLQLTGDNVN SFQARVFSSN DIGERIELSD GTYTLTELNS
360 370 380 390 400
PAGYSIAEPI TFKVEAGKVY TIIDGKQIEN PNKEIVEPYS VEAYNDFEEF
410 420 430 440 450
SVLTTQNYAK FYYAKNKNGS SQVVYCFNAD LKSPPDSEDG GKTMTPDFTT
460 470 480 490 500
GEVKYTHIAG RDLFKYTVKP RDTDPDTFLK HIKKVIEKGY REKGQAIEYS
510 520 530 540 550
GLTETQLRAA TQLAIYYFTD SAELDKDKLK DYHGFGDMND STLAVAKILV
560 570 580 590 600
EYAQDSNPPQ LTDLDFFIPN NNKYQSLIGT QWHPEDLVDI IRMEDKKEVI
610 620 630 640 650
PVTHNLTLRK TVTGLAGDRT KDFHFEIELK NNKQELLSQT VKTDKTNLEF
660 670 680 690 700
KDGKATINLK HGESLTLQGL PEGYSYLVKE TDSEGYKVKV NSQEVANATV
710 720 730 740 750
SKTGITSDET LAFENNKEPV VPTGVDQKIN GYLALIVIAG ISLGIWGIHT

IRIRKHD
Length:757
Mass (Da):85,143
Last modified:March 1, 2003 - v1
Checksum:i363414E6FF078DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU725515 Genomic DNA. Translation: ACH87879.1.
AB083107 Genomic DNA. Translation: BAC20340.1.
RefSeqiWP_015055896.1. NZ_JHTQ01000003.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU725515 Genomic DNA. Translation: ACH87879.1.
AB083107 Genomic DNA. Translation: BAC20340.1.
RefSeqiWP_015055896.1. NZ_JHTQ01000003.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2XI9X-ray1.90A/B286-723[»]
2XICX-ray2.90A/B286-723[»]
2XIDX-ray2.65A/B286-723[»]
4BUGX-ray2.80A/B285-723[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR023849. CHP03934_TQXA.
IPR013552. Thioester_dom.
[Graphical view]
PfamiPF08341. TED. 2 hits.
[Graphical view]
TIGRFAMsiTIGR03934. TQXA_dom. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Characterizaition of collagen binding protein (Cpa) of M1-type group A streptococcus."
    Miyoshi-Akiyama T., Wakisaka N., Zhao J., Uchiyama T.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 291Imported.
  2. "Sequence variation in group A Streptococcus pili and association of pilus backbone types with lancefield T serotypes."
    Falugi F., Zingaretti C., Pinto V., Mariani M., Amodeo L., Manetti A.G., Capo S., Musser J.M., Orefici G., Margarit I., Telford J.L., Grandi G., Mora M.
    J. Infect. Dis. 198:1834-1841(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3348Imported.
  3. "A highly unusual thioester bond in a pilus adhesin is required for efficient host cell interaction."
    Pointon J.A., Smith W.D., Saalbach G., Crow A., Kehoe M.A., Banfield M.J.
    J. Biol. Chem. 285:33858-33866(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 286-723.
  4. "Intramolecular isopeptide but not internal thioester bonds confer proteolytic and significant thermal stability to the S. pyogenes pilus adhesin Spy0125."
    Walden M., Crow A., Nelson M.D., Banfield M.J.
    Proteins 82:517-527(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 285-723.

Entry informationi

Entry nameiQ8GRA2_STRPY
AccessioniPrimary (citable) accession number: Q8GRA2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.