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Protein

Protein-glutamine gamma-glutamyltransferase

Gene
N/A
Organism
Streptomyces cinnamoneus (Streptoverticillium cinnamoneum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491By similarity
Active sitei340 – 3401By similarity
Active sitei359 – 3591By similarity

GO - Molecular functioni

  1. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-glutamine gamma-glutamyltransferase (EC:2.3.2.13)
Alternative name(s):
Transglutaminase
Short name:
TGase
OrganismiStreptomyces cinnamoneus (Streptoverticillium cinnamoneum)
Taxonomic identifieri53446 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces cinnamoneus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Tat-type signalPROSITE-ProRule annotationAdd
BLAST
Propeptidei30 – 8556By similarityPRO_0000033658Add
BLAST
Chaini86 – 416331Protein-glutamine gamma-glutamyltransferasePROSITE-ProRule annotationPRO_0000033659Add
BLAST

Post-translational modificationi

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Keywords - PTMi

Zymogen

Structurei

3D structure databases

ProteinModelPortaliQ8GR90.
SMRiQ8GR90. Positions 87-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial TGase family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.90.1360.10. 1 hit.
InterProiIPR006311. TAT_signal.
IPR015107. Transglut_prok.
[Graphical view]
PfamiPF09017. Transglut_prok. 1 hit.
[Graphical view]
PIRSFiPIRSF037210. Transglut_prok. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8GR90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKRRRLLAF ATVGAVICTA GFTPSVSQAA SSGDGEEKGS YAETHGLTAD
60 70 80 90 100
DVESINALNE RALTLGQPGK PPKELPPSAS APSRAPSDDR ETPPAEPLDR
110 120 130 140 150
MPEAYRAYGG RATTVVNNYI RKWQQVYSHR DGKKQQMTEE QREKLSYGCV
160 170 180 190 200
GVTWVNSGPY PTNRLAFASF DENKYKNDLK NTSPRPDETR AEFEGRIAKG
210 220 230 240 250
SFDEGKGFKR ARDVASVMNK ALENAHDEGT YINNLKTELT NNNDALLRED
260 270 280 290 300
SRSNFYSALR NTPSFKERDG GNYDPSKMKA VIYSKHFWSG QDQRGSSDKR
310 320 330 340 350
KYGDPEAFRP DQGTGLVDMS KDRSIPRSPA KPGEGWVNFD YGWFGAQTEA
360 370 380 390 400
DADKTTWTHG DHYHAPNSDL GPMHVHESKF RKWSAGYADF DRGAYVITFI
410
PKSWNTAPAK VEQGWP
Length:416
Mass (Da):46,394
Last modified:February 28, 2003 - v1
Checksum:i677DA9778829839D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085698 Genomic DNA. Translation: BAC24766.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085698 Genomic DNA. Translation: BAC24766.1.

3D structure databases

ProteinModelPortaliQ8GR90.
SMRiQ8GR90. Positions 87-416.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.90.1360.10. 1 hit.
InterProiIPR006311. TAT_signal.
IPR015107. Transglut_prok.
[Graphical view]
PfamiPF09017. Transglut_prok. 1 hit.
[Graphical view]
PIRSFiPIRSF037210. Transglut_prok. 1 hit.
PROSITEiPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Streptoverticillium cinnamoneum IFO12852 TGase gene."
    Yokoyama K.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 11874 / DSM 40005 / NBRC 12852 / JCM 4633 / NCIMB 8851 / NRRL B-1285 / VKM Ac-876.

Entry informationi

Entry nameiTGAS_STRCJ
AccessioniPrimary (citable) accession number: Q8GR90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 6, 2003
Last sequence update: February 28, 2003
Last modified: September 30, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.