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Q8GR90 (TGAS_STRCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein-glutamine gamma-glutamyltransferase

EC=2.3.2.13
Alternative name(s):
Transglutaminase
Short name=TGase
OrganismStreptomyces cinnamoneus (Streptoverticillium cinnamoneum)
Taxonomic identifier53446 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins By similarity.

Catalytic activity

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Post-translational modification

Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

Sequence similarities

Belongs to the bacterial TGase family.

Ontologies

Keywords
   DomainSignal
   Molecular functionAcyltransferase
Transferase
   PTMZymogen
Gene Ontology (GO)
   Molecular_functionprotein-glutamine gamma-glutamyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929Tat-type signal Potential
Propeptide30 – 8556 By similarity
PRO_0000033658
Chain86 – 416331Protein-glutamine gamma-glutamyltransferase By similarity
PRO_0000033659

Sites

Active site1491 By similarity
Active site3401 By similarity
Active site3591 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8GR90 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 677DA9778829839D

FASTA41646,394
        10         20         30         40         50         60 
MHKRRRLLAF ATVGAVICTA GFTPSVSQAA SSGDGEEKGS YAETHGLTAD DVESINALNE 

        70         80         90        100        110        120 
RALTLGQPGK PPKELPPSAS APSRAPSDDR ETPPAEPLDR MPEAYRAYGG RATTVVNNYI 

       130        140        150        160        170        180 
RKWQQVYSHR DGKKQQMTEE QREKLSYGCV GVTWVNSGPY PTNRLAFASF DENKYKNDLK 

       190        200        210        220        230        240 
NTSPRPDETR AEFEGRIAKG SFDEGKGFKR ARDVASVMNK ALENAHDEGT YINNLKTELT 

       250        260        270        280        290        300 
NNNDALLRED SRSNFYSALR NTPSFKERDG GNYDPSKMKA VIYSKHFWSG QDQRGSSDKR 

       310        320        330        340        350        360 
KYGDPEAFRP DQGTGLVDMS KDRSIPRSPA KPGEGWVNFD YGWFGAQTEA DADKTTWTHG 

       370        380        390        400        410 
DHYHAPNSDL GPMHVHESKF RKWSAGYADF DRGAYVITFI PKSWNTAPAK VEQGWP 

« Hide

References

[1]"Streptoverticillium cinnamoneum IFO12852 TGase gene."
Yokoyama K.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 11874 / DSM 40005 / NBRC 12852 / JCM 4633 / NCIMB 8851 / NRRL B-1285 / VKM Ac-876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB085698 Genomic DNA. Translation: BAC24766.1.

3D structure databases

ProteinModelPortalQ8GR90.
SMRQ8GR90. Positions 87-416.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.90.1360.10. 1 hit.
InterProIPR006311. TAT_signal.
IPR015107. Transglut_prok.
[Graphical view]
PfamPF09017. Transglut_prok. 1 hit.
[Graphical view]
PIRSFPIRSF037210. Transglut_prok. 1 hit.
PROSITEPS51318. TAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTGAS_STRCJ
AccessionPrimary (citable) accession number: Q8GR90
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families