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Q8GR90

- TGAS_STRCJ

UniProt

Q8GR90 - TGAS_STRCJ

Protein

Protein-glutamine gamma-glutamyltransferase

Gene
N/A
Organism
Streptomyces cinnamoneus (Streptoverticillium cinnamoneum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.By similarity

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei149 – 1491By similarity
    Active sitei340 – 3401By similarity
    Active sitei359 – 3591By similarity

    GO - Molecular functioni

    1. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-glutamine gamma-glutamyltransferase (EC:2.3.2.13)
    Alternative name(s):
    Transglutaminase
    Short name:
    TGase
    OrganismiStreptomyces cinnamoneus (Streptoverticillium cinnamoneum)
    Taxonomic identifieri53446 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces cinnamoneus group

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Tat-type signalPROSITE-ProRule annotationAdd
    BLAST
    Propeptidei30 – 8556By similarityPRO_0000033658Add
    BLAST
    Chaini86 – 416331Protein-glutamine gamma-glutamyltransferasePROSITE-ProRule annotationPRO_0000033659Add
    BLAST

    Post-translational modificationi

    Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.

    Keywords - PTMi

    Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliQ8GR90.
    SMRiQ8GR90. Positions 87-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bacterial TGase family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.90.1360.10. 1 hit.
    InterProiIPR006311. TAT_signal.
    IPR015107. Transglut_prok.
    [Graphical view]
    PfamiPF09017. Transglut_prok. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037210. Transglut_prok. 1 hit.
    PROSITEiPS51318. TAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8GR90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKRRRLLAF ATVGAVICTA GFTPSVSQAA SSGDGEEKGS YAETHGLTAD    50
    DVESINALNE RALTLGQPGK PPKELPPSAS APSRAPSDDR ETPPAEPLDR 100
    MPEAYRAYGG RATTVVNNYI RKWQQVYSHR DGKKQQMTEE QREKLSYGCV 150
    GVTWVNSGPY PTNRLAFASF DENKYKNDLK NTSPRPDETR AEFEGRIAKG 200
    SFDEGKGFKR ARDVASVMNK ALENAHDEGT YINNLKTELT NNNDALLRED 250
    SRSNFYSALR NTPSFKERDG GNYDPSKMKA VIYSKHFWSG QDQRGSSDKR 300
    KYGDPEAFRP DQGTGLVDMS KDRSIPRSPA KPGEGWVNFD YGWFGAQTEA 350
    DADKTTWTHG DHYHAPNSDL GPMHVHESKF RKWSAGYADF DRGAYVITFI 400
    PKSWNTAPAK VEQGWP 416
    Length:416
    Mass (Da):46,394
    Last modified:March 1, 2003 - v1
    Checksum:i677DA9778829839D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085698 Genomic DNA. Translation: BAC24766.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085698 Genomic DNA. Translation: BAC24766.1 .

    3D structure databases

    ProteinModelPortali Q8GR90.
    SMRi Q8GR90. Positions 87-416.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.90.1360.10. 1 hit.
    InterProi IPR006311. TAT_signal.
    IPR015107. Transglut_prok.
    [Graphical view ]
    Pfami PF09017. Transglut_prok. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037210. Transglut_prok. 1 hit.
    PROSITEi PS51318. TAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Streptoverticillium cinnamoneum IFO12852 TGase gene."
      Yokoyama K.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 11874 / DSM 40005 / NBRC 12852 / JCM 4633 / NCIMB 8851 / NRRL B-1285 / VKM Ac-876.

    Entry informationi

    Entry nameiTGAS_STRCJ
    AccessioniPrimary (citable) accession number: Q8GR90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3