Reviewed, UniProtKB/Swiss-Prot Q8GR90 (TGAS_STRCJ)

Names and origin

Protein names	Recommended name:     Protein-glutamine gamma-glutamyltransferase     EC=2.3.2.13 Alternative name(s):     Transglutaminase       Short name=TGase
Organism	Streptomyces cinnamoneus
Taxonomic identifier	53446 [NCBI]
Taxonomic lineage	Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins By similarity.
Catalytic activity	Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.
Post-translational modification	Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
Sequence similarities	Belongs to the bacterial TGase family.

Ontologies

Keywords
Domain	Signal
Molecular function	Acyltransferase Transferase
PTM	Zymogen
Gene Ontology (GO)
Molecular function	acyltransferase activity Inferred from electronic annotation. Source: UniProtKB-KW protein-glutamine gamma-glutamyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Tat-type signal Potential
	Propeptide	30 – 85	56	By similarity		PRO_0000033658
	Chain	86 – 416	331	Protein-glutamine gamma-glutamyltransferase By similarity		PRO_0000033659
Sites
	Active site	149	1	By similarity
	Active site	340	1	By similarity
	Active site	359	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8GR90-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 677DA9778829839D	FASTA	416	46,394
	10 20 30 40 50 60 MHKRRRLLAF ATVGAVICTA GFTPSVSQAA SSGDGEEKGS YAETHGLTAD DVESINALNE 70 80 90 100 110 120 RALTLGQPGK PPKELPPSAS APSRAPSDDR ETPPAEPLDR MPEAYRAYGG RATTVVNNYI 130 140 150 160 170 180 RKWQQVYSHR DGKKQQMTEE QREKLSYGCV GVTWVNSGPY PTNRLAFASF DENKYKNDLK 190 200 210 220 230 240 NTSPRPDETR AEFEGRIAKG SFDEGKGFKR ARDVASVMNK ALENAHDEGT YINNLKTELT 250 260 270 280 290 300 NNNDALLRED SRSNFYSALR NTPSFKERDG GNYDPSKMKA VIYSKHFWSG QDQRGSSDKR 310 320 330 340 350 360 KYGDPEAFRP DQGTGLVDMS KDRSIPRSPA KPGEGWVNFD YGWFGAQTEA DADKTTWTHG 370 380 390 400 410 DHYHAPNSDL GPMHVHESKF RKWSAGYADF DRGAYVITFI PKSWNTAPAK VEQGWP

References

[1]	"Streptoverticillium cinnamoneum IFO12852 TGase gene." Yokoyama K. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 11874 / DSM 40005 / IFO 12852 / JCM 4633 / NCIMB 8851.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB085698 Genomic DNA. Translation: BAC24766.1.
3D structure databases
HSSP	HSSP built from PDB template 1IU4 based on UniProtKB P81453.
SMR	Q8GR90. Positions 87-416.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.3.2.13. 96004.
Family and domain databases
InterPro	IPR006311. TAT_signal. IPR015107. Transglut_prok. IPR017909. Twin_arg_translocation_Tat. [Graphical view]
Pfam	PF09017. Transglut_prok. 1 hit. [Graphical view]
PIRSF	PIRSF037210. Transglut_prok. 1 hit.
TIGRFAMs	TIGR01409. TAT_signal_seq. 1 hit.
PROSITE	PS51318. TAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TGAS_STRCJ

Accession

Primary (citable) accession number: Q8GR90

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	March 1, 2003
Last modified:	September 22, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)