Q8GQ92 (CCMA_PSEAI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c biogenesis ATP-binding export protein CcmA
EC=3.6.3.41

Alternative name(s):
Heme exporter protein A

Gene names

Name:

ccmA

Organism

Pseudomonas aeruginosa

Taxonomic identifier

287 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas

Protein attributes

Sequence length	203 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system By similarity. HAMAP MF_01707
Catalytic activity	ATP + H2O + heme(In) = ADP + phosphate + heme(Out). HAMAP MF_01707
Subunit structure	The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB) By similarity.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01707.
Sequence similarities	Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Cytochrome c-type biogenesis Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	cytochrome complex assembly Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW heme-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Cytochrome c biogenesis ATP-binding export protein CcmA HAMAP MF_01707		PRO_0000092196
Regions
	Domain	2 – 203	202	ABC transporter
	Nucleotide binding	34 – 41	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8GQ92 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 3E5996CB4FEFA770	FASTA	203	22,538
	10 20 30 40 50 60 MLEALDLAGV RGERRLFDHL TFRIVPGECL SVHGENGSGK TTLLRTLAGF ATPAAGRVLW 70 80 90 100 110 120 KGKPLRNQWS EYQRELVYNG HGIGLKEDLN ALDNLLAAAA IAGEPVTTEC VESALDEVGL 130 140 150 160 170 180 AEHRHLPFRM LSQGQKRRAS LARLLLYRRK LWILDEPSTA LDQFGARWLG ELIHRHQSRG 190 200 GMVVLTSHQE LALKTSQTVR MGA

References

[1]

"Gene islands integrated into tRNA(Gly) genes confer genome diversity on a Pseudomonas aeruginosa clone." Larbig K.D., Christmann A., Johann A., Klockgether J., Hartsch T., Merkl R., Wiehlmann L., Fritz H.-J., Tuemmler B. J. Bacteriol. 184:6665-6680(2002) [PubMed: 12426355] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: C.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF440523 Genomic DNA. Translation: AAN62111.1.
3D structure databases
ProteinModelPortal	Q8GQ92.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01707. ABC_ATPase_CcmA. [Tree]
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR005895. ABC_transptr_haem_export_CcmA. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01189. CcmA. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51243. CCMA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCMA_PSEAI

Accession

Primary (citable) accession number: Q8GQ92

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 1, 2003
Last modified:	November 16, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program